权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Iron paraCEST MRI Contrast Agents for Monitoring Tumor Acidosis

用于监测肿瘤酸中毒的铁 paraCEST MRI 造影剂

基本信息

批准号：
8606835
负责人：
Janet Ruth Morrow
金额：
$ 7.87万
依托单位：
STATE UNIVERSITY OF NEW YORK AT BUFFALO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-01-22 至 2014-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8606835
关键词：
Acidosis Age Amines Bicarbonates Breast Cancer Model Breast Carcinoma Chemicals Chemistry Clinical Collaborations Complex Contrast Media Dendrimers Dependence Development Dose Drug Addiction Electron Transport Complex III Extracellular Space FDA approved Frequencies Funding Goals Grant Human body Image Investigational Drugs Ions Iron Laboratories Lanthanoid Series Elements Lead Magnetic Resonance Imaging Malignant Neoplasms Mammary Neoplasms Maps Metals Modeling Monitor Mus NMR Spectroscopy Neoplasm Metastasis Oral Physiologic pulse Protons Renal function Research Research Personnel Resolution Scientist Seeds Series Signal Transduction Testing Time Tissues Toxic effect Tumor Tissue Water Work base design experience imaging modality improved in vivo macromolecule mouse model non-invasive imaging public health relevance radiofrequency ratiometric response sensor small molecule tumor uptake

项目摘要

DESCRIPTION (provided by applicant): Treatments that alkalinize the acidic extracellular space of tumors are under development as inexpensive anticancer alternatives that reduce metastasis and malignancy. One of these alkalinizing therapies, oral bicarbonate, has been shown to be particularly effective and has been recently approved by the FDA as an investigational new drug for clinical cancer trials. A drawback of this therapy is that high doss of bicarbonate impair kidney function, making it important to optimize bicarbonate treatments. We propose to develop a new class of small molecule MRI contrast agents for the registration of pH in tumor tissue to monitor and optimize alkalinizing treatments. These efforts will use pH sensitive paraCEST MRI contrast agents with two different exchangeable protons that can be used for ratiometric concentration independent pH monitoring in tissue. (paraCEST = paramagnetic chemical exchange saturation transfer). This approach is under development for lanthanide (Ln(III)) containing contrast agents, but is problematic because of the lack of different types of exchangeable protons with large paramagnetic induced proton shifts. Work in the Morrow laboratory has shown that iron (Fe(II)) complexes can be developed into paraCEST MRI contrast agents. Fe(II) complexes have sharper and more highly shifted proton resonances for CEST than the Ln(III) complexes currently under development. In addition, the iron complexes may be potentially be less expensive and less toxic. We will develop these new iron based agents both as small molecule imaging agents and as dendrimers to control retention and tumor uptake. These agents will be tested in mouse mammary tumors.

描述（由申请人提供）：正在开发碱化肿瘤酸性细胞外间隙的治疗方法，作为降低转移和恶性肿瘤的廉价抗癌替代方案。这些碱化疗法之一，口服碳酸氢盐，已被证明是特别有效的，最近已被FDA批准为临床癌症试验的研究性新药。这种疗法的缺点是高剂量的碳酸氢盐损害肾功能，因此优化碳酸氢盐治疗很重要。我们建议开发一类新的小分子MRI造影剂，用于记录肿瘤组织中的pH值，以监测和优化碱化治疗。这些努力将使用pH敏感的paraCEST MRI造影剂，其具有两种不同的可交换质子，可用于组织中的比率浓度无关pH监测。（paraCEST =顺磁性化学交换饱和转移）。该方法正在开发用于含镧系元素（Ln（III））的造影剂，但由于缺乏具有大的顺磁诱导质子位移的不同类型的可交换质子而存在问题。 Morrow实验室的工作表明，铁（Fe（II））络合物可以开发成paraCEST MRI造影剂。 Fe（II）配合物具有比目前正在开发的Ln（III）配合物更尖锐和更高度移位的CEST质子共振。此外，铁络合物可能更便宜且毒性更低。我们将开发这些新的铁基药物作为小分子成像剂和树枝状聚合物，以控制保留和肿瘤摄取。这些药物将在小鼠乳腺肿瘤中进行试验。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A redox-activated MRI contrast agent that switches between paramagnetic and diamagnetic states.

DOI：
10.1002/anie.201306394
发表时间：
2013-12-23
期刊：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
影响因子：
16.6
作者：
Tsitovich, Pavel B.;Spernyak, Joseph A.;Morrow, Janet R.
通讯作者：
Morrow, Janet R.

Seven-coordinate Co(II), Fe(II) and six-coordinate Ni(II) amide-appended macrocyclic complexes as ParaCEST agents in biological media.

七配位 Co(II)、Fe(II) 和六配位 Ni(II) 酰胺附加大环配合物作为生物介质中的 ParaCEST 试剂。

DOI：
10.1021/ic5006083
发表时间：
2014
期刊：
Inorganic chemistry
影响因子：
4.6
作者：
Olatunde,AbiolaO;Cox,JordanM;Daddario,MichaelD;Spernyak,JosephA;Benedict,JasonB;Morrow,JanetR
通讯作者：
Morrow,JanetR

CoCEST: cobalt(II) amide-appended paraCEST MRI contrast agents.