Investigation of cellular abnormalities and synapse formation in DOCK8 immunodeficiency

DOCK8 免疫缺陷细胞异常和突触形成的研究

• 批准号: nhmrc : 1022922
• 负责人: Dr Katrina Randall
• 金额: $ 21.22万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-cellular-abnormalities-dock8-immunodeficiency/110229
• 关键词: Investigation; cellular; abnormalities; synapse; formation

Why do some people get allergies? Or serious infections? To investigate this we will study mice and humans with a mutation in the DOCK8 gene. People with mutations in the DOCK8 gene get Hyper-IgE Syndrome and develop severe viral infections of the skin as well as allergic disease. By investigating how DOCK8 works in the cells of the immune system, we hope to understand why these infections and allergies occur and find out why these problems can also happen in those without this specific genetic defect.

为什么有些人会过敏？或者严重感染？为了研究这一点，我们将研究DOCK8基因突变的小鼠和人类。DOCK8基因突变的人会患上高IgE综合征，并发展成严重的皮肤病毒感染和过敏性疾病。通过研究DOCK8在免疫系统细胞中的作用，我们希望了解为什么会发生这些感染和过敏，并找出为什么这些问题也会发生在没有这种特定遗传缺陷的人身上。