The Brief Research in Aging and Interdisciplinary Neurosciences

描述（由申请人提供）：哥伦比亚大学医学中心神经学系是多学科神经学研究的丰富场所，特别关注与衰老神经系统相关的疾病。在这个提案中，衰老和跨学科神经科学（BRAIN）项目的简要研究，我们已经制定了一个全面的方法，为在生物医学，行为和临床研究方面发展职业生涯的博士生开发一个正式的研究项目。这项工作将通过为这些学生提供简短而密集的暑期研究培训经验来合作进行，并有可能随后发展成纵向研究项目。研究培训将通过基础神经科学、神经病理学、神经遗传学、神经心理学、中风、阿尔茨海默病及相关疾病、运动神经元疾病、帕金森病及相关疾病、癫痫等领域的持续研究，以及治疗这些疾病患者的神经学临床试验，为基础、行为和临床研究提供机会。此外，在密集的研究经验过程中，将提供全面的结构化研究教育课程，主题包括良好的临床实践，基础研究方法，抽象作者介绍和海报展示，统计概念和分析方法的介绍，以及与衰老相关的最常见神经系统疾病的流行病学和病理生理学综述，因此可能被研究。我们的机构在培养世界各地的学术神经科医生方面有着最强的记录，这样一个短期的，高强度的项目将通过对神经学研究的实际介绍，对研究原则的全面回顾，建立在丰富的资源基础上，从而确保这些学生在该领域发展研究事业的最佳机会。

DESCRIPTION (provided by applicant): The Department of Neurology at Columbia University Medical Center serves as a rich site for multidisciplinary neurological research, with particular focus on disorders associated with the aging nervous system. In this proposal, the Brief Research in Aging and Interdisciplinary Neurosciences (BRAIN) program, we have developed a comprehensive approach to develop a formal research program for predoctoral students early in developing careers in biomedical, behavioral and clinical research. The work will be collaboratively approached through brief but intensive mentored summer research training experiences for these students, with the potential for subsequent development of a longitudinal research program. The research training will provide opportunities in basic, behavioral and clinical research through ongoing research in the fields of basic neuroscience, neuropathology, neurogenetics, neuropsychology, stroke, Alzheimer disease and related disorders, motor neuron disease, Parkinson disease and related disorders, and epilepsy, as well as neurologic clinical trials treating patients with these disorders. In addition, a comprehensive structured research education curriculum will be given over the course of the intense research experience, with topics including good clinical practice, basic research methodologies, introductions to abstract authorship and poster presentations, and introduction of statistical concepts and approach to analyses, as well as epidemiologic and pathophysiologic reviews of the most common neurologic disorders associated with aging and thus likely to be studied. Our institution has the strongest track record of developing academic neurologists of anywhere worldwide, and such a short-term, intense program will build upon this wealth of resources through hands-on introductions to neurological research, comprehensive review of principles of research, and thus assure the best opportunity for these students to develop research careers in the field.