Inflammation Biomarkers for Diagnosis and Prognosis of Early Stage Lung Cancer

用于早期肺癌诊断和预后的炎症生物标志物

• 批准号: 8938193
• 负责人: Brid Ryan
• 金额: $ 8.24万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8938193
• 关键词: Address; American; Benign; Biological Markers; Clinical; Cytokine Signaling; Diagnosis; Diagnostic; Dose; Early Diagnosis; European; Goals; Health; Human; Inflammation; Inflammatory; Knowledge; Lesion; Lung; Lung nodule; Malignant - descriptor; Malignant neoplasm of lung; Modeling; Operative Surgical Procedures; Patients; Plasma; Prognostic Marker; Prospective Studies; Public Health; Recurrence; Relapse; Risk; Sampling; Specificity; Spiral Computed Tomography; Staging; Translating; cancer diagnosis; chemotherapy; clinical decision-making; cytokine; experience; mortality; outcome forecast; prognostic; screening; tool; tumor

Building on our previous studies where we found increased circling cytokines among patients with a lung cancer diagnosis, we are examining plasma samples from the National Lung Screening Trial for a cytokine diagnostic and prognostic signature. This study extends previous studies as a) this is a prospective study and b) the lesions both benign and malignant, were detected b low dose helical CT. We are also examining whether the signal from cytokines declines following surgery and tracks with tumor recurrence, as a preliminary study to query whether cytokines could be used to model tumor recurrence. This study is currently ongoing.

在我们之前的研究基础上，我们发现肺癌诊断患者中循环细胞因子增加，我们正在检查国家肺筛查试验的血浆样本，以寻找细胞因子诊断和预后的标志。这项研究扩展了以往的研究：a)这是一项前瞻性研究，b)良性和恶性病变都是通过低剂量螺旋CT发现的。我们还在检查手术后细胞因子的信号是否下降，并跟踪肿瘤复发，作为一项初步研究，以质疑细胞因子是否可以用来模拟肿瘤复发。这项研究目前正在进行中。