Lung Cancer Health Disparities

肺癌健康差异

• 批准号: 10014726
• 负责人: Brid Ryan
• 金额: $ 131.49万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10014726
• 关键词: African American; American; Atlases; Biological; Biology; Blood; Code; Epidemiology; Etiology; European; Gene Expression; Genetic; Goals; Heterogeneity; Incidence; Knowledge; Laboratories; Malignant neoplasm of lung; Methylation; MicroRNAs; Molecular Analysis; Molecular Epidemiology; Patient-Focused Outcomes; Pattern; Play; Population; Population Study; Prevention; Prevention strategy; Prognostic Marker; Proteins; Research; Risk; Sampling; Smoking; Tissues; Translating; Tumor Biology; United States; Work; base; cancer health disparity; cancer prevention; cytokine; diagnostic biomarker; epidemiology study; health disparity; improved; interdisciplinary approach; men; precision medicine; racial disparity; treatment strategy

This project uses classical epidemiology, molecular epidemiology and precision medicine. As the main causes of the disparities in incidence are unknown, we are conducting population studies to assess the potential causes. We examine heterogeneity in exposures between European Americans and African Americans. Understanding such differences could provide clues for etiology, prevention and new treatments. Secondly, we are conducting molecular epidemiology studies of blood-based proteins and examining cytokine profiles in these populations. Our ongoing work shows that cytokine profiles are promising risk, diagnostic and prognostic biomarkers. We are also currently undertaking a comprehensive molecular analysis of lung cancer tissues from European Americans and African Americans and building a precision medicine atlas of lung cancer in African Americans. These samples are being analysed for microRNA, coding gene expression, genetics and methylation. The goals of these analyses are to understand whether differences in tumor biology exist in lung cancers from African Americans and European Americans. The differences that we have found could be leveraged to improve patient outcomes.

本项目运用经典流行病学、分子流行病学和精准医学。由于发病率差异的主要原因尚不清楚，我们正在进行人口研究，以评估潜在的原因。我们研究了欧洲裔美国人和非洲裔美国人之间暴露的异质性。了解这些差异可以为病因、预防和新的治疗提供线索。其次，我们正在进行基于血液的蛋白质的分子流行病学研究，并检查这些人群的细胞因子谱。我们正在进行的工作表明，细胞因子谱是有希望的风险，诊断和预后的生物标志物。我们目前也在对欧洲裔美国人和非洲裔美国人的肺癌组织进行全面的分子分析，并建立非洲裔美国人肺癌的精确医学图谱。这些样本正在进行microRNA、编码基因表达、遗传学和甲基化分析。这些分析的目的是了解非裔美国人和欧裔美国人的肺癌肿瘤生物学是否存在差异。我们发现的差异可以用来改善病人的治疗效果。