Gene-Environment Interactions in Lung Cancer
肺癌中基因与环境的相互作用
基本信息
- 批准号:10014727
- 负责人:
- 金额:$ 56.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:BrainBronchiDRD1 geneDataDopamineDopamine AgonistsDopamine ReceptorEnvironmental Tobacco SmokeFamilyGenetic PolymorphismHumanKnowledgeLungMalignant NeoplasmsMalignant neoplasm of lungMetabolismMolecularPathway interactionsPatternPlayResearchRespirationRoleSignal TransductionSmokingStructure of parenchyma of lungTherapeutic AgentsTumor Suppressor Proteinscancer riskenvironmental tobacco smoke exposuregene environment interactionindividualized preventioninter-individual variationnever smokerprogramsreceptor
项目摘要
We identified a gene environment interaction between DRD1 and secondhand smoke in relation to lung cancer risk--an observation that was seen in ever and never smokers. While dopamine signaling and its receptors are well characterized in the brain, there is a paucity of data regarding the role and the expression pattern of dopamine and its receptors in the normal lung. Previous studies have shown that dopamine plays an important role in bronchi-dilation and respiration, however a comprehensive analysis of dopamine, its receptors, transporters and metabolism has not been conducted. We are therefore mapping the dopamine axis in both normal lung tissue and human lung cancer. Our initial studies suggest that certain subtypes of the dopamine receptor family may function as tumor suppressors and we are currently validating those observations and investigating the molecular mechanism. In addition, we are examining the efficacy of specific dopamine receptor agonists and antagonists as therapeutic agents against cancer and analyzing the key mechanistic pathways involved.
我们确定了DRD 1和二手烟与肺癌风险之间的基因环境相互作用-这一观察结果在曾经和从未吸烟者中观察到。虽然多巴胺信号传导及其受体在大脑中得到了很好的表征,但关于多巴胺及其受体在正常肺中的作用和表达模式的数据很少。以往的研究表明,多巴胺在支气管扩张和呼吸中起着重要作用,但尚未对多巴胺及其受体、转运蛋白和代谢进行全面分析。因此,我们正在绘制正常肺组织和人类肺癌中的多巴胺轴。我们的初步研究表明,多巴胺受体家族的某些亚型可能具有肿瘤抑制剂的功能,我们目前正在验证这些观察结果并研究分子机制。此外,我们正在研究特定的多巴胺受体激动剂和拮抗剂作为癌症治疗药物的疗效,并分析所涉及的关键机制途径。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Brid Ryan其他文献
Brid Ryan的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Brid Ryan', 18)}}的其他基金
Causes and Consequences of Lung Cancer Health Disparities
肺癌健康差异的原因和后果
- 批准号:
9153979 - 财政年份:
- 资助金额:
$ 56.35万 - 项目类别:
Inflammation Biomarkers for Diagnosis and Prognosis of Early Stage Lung Cancer
用于早期肺癌诊断和预后的炎症生物标志物
- 批准号:
8938193 - 财政年份:
- 资助金额:
$ 56.35万 - 项目类别:
Understanding the Science Behind Racial Disparities in Lung Cancer Incidence
了解肺癌发病率种族差异背后的科学依据
- 批准号:
8938190 - 财政年份:
- 资助金额:
$ 56.35万 - 项目类别:
Examining the Inverse Relationship Between Parkinsons Disease and Lung Cancer
检查帕金森病和肺癌之间的负相关关系
- 批准号:
8938191 - 财政年份:
- 资助金额:
$ 56.35万 - 项目类别:
Inflammatory Biomarkers of Diagnosis and Prognosis in Early Stage Lung Cancer
早期肺癌诊断和预后的炎症生物标志物
- 批准号:
9343984 - 财政年份:
- 资助金额:
$ 56.35万 - 项目类别:
Causes and Consequences of Lung Cancer Health Disparities
肺癌健康差异的原因和后果
- 批准号:
9343982 - 财政年份:
- 资助金额:
$ 56.35万 - 项目类别:
相似海外基金
Capturing the in situ behavior of airway smooth muscle in human bronchi using an ex vivo system that simulates breathing maneuvers
使用模拟呼吸动作的离体系统捕获人支气管中气道平滑肌的原位行为
- 批准号:
RGPIN-2014-04395 - 财政年份:2019
- 资助金额:
$ 56.35万 - 项目类别:
Discovery Grants Program - Individual
Capturing the in situ behavior of airway smooth muscle in human bronchi using an ex vivo system that simulates breathing maneuvers
使用模拟呼吸动作的离体系统捕获人支气管中气道平滑肌的原位行为
- 批准号:
RGPIN-2014-04395 - 财政年份:2018
- 资助金额:
$ 56.35万 - 项目类别:
Discovery Grants Program - Individual
Capturing the in situ behavior of airway smooth muscle in human bronchi using an ex vivo system that simulates breathing maneuvers
使用模拟呼吸动作的离体系统捕获人支气管中气道平滑肌的原位行为
- 批准号:
RGPIN-2014-04395 - 财政年份:2017
- 资助金额:
$ 56.35万 - 项目类别:
Discovery Grants Program - Individual
Capturing the in situ behavior of airway smooth muscle in human bronchi using an ex vivo system that simulates breathing maneuvers
使用模拟呼吸动作的离体系统捕获人支气管中气道平滑肌的原位行为
- 批准号:
RGPIN-2014-04395 - 财政年份:2016
- 资助金额:
$ 56.35万 - 项目类别:
Discovery Grants Program - Individual
Capturing the in situ behavior of airway smooth muscle in human bronchi using an ex vivo system that simulates breathing maneuvers
使用模拟呼吸动作的离体系统捕获人支气管中气道平滑肌的原位行为
- 批准号:
RGPIN-2014-04395 - 财政年份:2015
- 资助金额:
$ 56.35万 - 项目类别:
Discovery Grants Program - Individual
Capturing the in situ behavior of airway smooth muscle in human bronchi using an ex vivo system that simulates breathing maneuvers
使用模拟呼吸动作的离体系统捕获人支气管中气道平滑肌的原位行为
- 批准号:
RGPIN-2014-04395 - 财政年份:2014
- 资助金额:
$ 56.35万 - 项目类别:
Discovery Grants Program - Individual
Relation between Bradykinin-induced human bronchi relaxation and endogenous epoxy-eicosanoid production.
缓激肽诱导的人支气管松弛与内源性环氧类二十烷酸产生之间的关系。
- 批准号:
253467 - 财政年份:2012
- 资助金额:
$ 56.35万 - 项目类别:
The role of homeostatic chemokine receptors on the migration of immune cells through the respiratory tract and during infectious diseases of the bronchi and the lung (B03)
稳态趋化因子受体对免疫细胞通过呼吸道迁移以及支气管和肺部感染性疾病期间的作用(B03)
- 批准号:
5376976 - 财政年份:2002
- 资助金额:
$ 56.35万 - 项目类别:
Collaborative Research Centres
MUSCLE ULTRASTRUCTURE IN TRACHEA, BRONCHI, LUNG VESSELS
气管、支气管、肺血管的肌肉超微结构
- 批准号:
3350016 - 财政年份:1987
- 资助金额:
$ 56.35万 - 项目类别:
MUSCLE ULTRASTRUCTURE IN TRACHEA, BRONCHI, LUNG VESSELS
气管、支气管、肺血管的肌肉超微结构
- 批准号:
3350018 - 财政年份:1985
- 资助金额:
$ 56.35万 - 项目类别: