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Elucidating cardiovascular phenotaypes employing genome editing of iPS cells

Elucidating cardiovascular phenotaypes employing genome editing of iPS cells
利用 iPS 细胞基因组编辑阐明心血管表型
批准号:
8689147
负责人:
Kristin Kay Baldwin
金额:
$210.18万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-07-05 至 2016-06-30

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中文摘要
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英文摘要
DESCRIPTION (provided by applicant): We aim to develop an innovative approach to generate, at high-throughput, isogenic induced pluripotent stem cells (iPSCs), and use their differentiated progeny to understand the impact of human genetic variation on the risk of developing coronary artery disease (CAD). A genomic variant associated with CAD, myocardial infarction (Ml), abdominal aortic aneurysm, and intracranial aneurysm is found in a stretch of chr9p21 devoid of known genes. We will use this locus as a model for our study; while focusing on 9p21, our overall approach will be broadly applicable to the study of HLBS diseases of complex genetic architecture.
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Contributions of cell type and exosome signaling to prodromal synaptic and circuit changes in Alzheimer's Disease models
  • 批准号:
    10540117
  • 项目类别:
  • 资助金额:
    $256.01万
  • 财政年份:
    2022
  • 负责人:
    Kristin Kay Baldwin
  • 依托单位:
Defining a transcriptional periodic table of the human brain using reprogramming
Defining a transcriptional periodic table of the human brain using reprogramming
  • 批准号:
    9163516
  • 项目类别:
  • 资助金额:
    $134.75万
  • 财政年份:
    2016
  • 负责人:
    Kristin Kay Baldwin
  • 依托单位:
Genome-wide investigation of somatic mutation in the developing and aging brain
  • 批准号:
    8762213
  • 项目类别:
  • 资助金额:
    $75.29万
  • 财政年份:
    2014
  • 负责人:
    Kristin Kay Baldwin
  • 依托单位:
海外基金