Elucidating cardiovascular phenotaypes employing genome editing of iPS cells
Elucidating cardiovascular phenotaypes employing genome editing of iPS cells
批准号:
8689147
负责人:
Kristin Kay Baldwin
金额:
$210.18万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-07-05 至 2016-06-30
关键词:
9p21Abdominal Aortic AneurysmAffectArchitectureBlood VesselsCardiovascular systemCellsChromatinCollectionComplexCoronary ArteriosclerosisDNADataDiseaseElderlyEndotheliumGenerationsGenesGeneticGenetic TranscriptionGenetic VariationGenomeGenomicsGenotypeHaplotypesHuman GeneticsIndividualIntracranial AneurysmMeasuresModelingMolecularMyocardial InfarctionOpen Reading FramesPatientsPhasePhenotypePrincipal InvestigatorRiskSmooth MuscleSmooth Muscle MyocytesStretchingTechnologyVariantcohortepigenomeevidence basegenome wide association studyinduced pluripotent stem cellinnovationprotective effectsmall moleculetool
中文摘要
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英文摘要
DESCRIPTION (provided by applicant):
We aim to develop an innovative approach to generate, at high-throughput, isogenic induced pluripotent stem cells (iPSCs), and use their differentiated progeny to understand the impact of human genetic variation on the risk of developing coronary artery disease (CAD). A genomic variant associated with CAD, myocardial infarction (Ml), abdominal aortic aneurysm, and intracranial aneurysm is found in a stretch of chr9p21 devoid of known genes. We will use this locus as a model for our study; while focusing on 9p21, our overall approach will be broadly applicable to the study of HLBS diseases of complex genetic architecture.
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会议论文
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The architecture and development of a sensory processing circuit for smell
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The architecture and development of a sensory processing circuit for smell
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Elucidating cardiovascular phenotaypes employing genome editing of iPS cells
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Elucidating cardiovascular phenotaypes employing genome editing of iPS cells
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依托单位:
Elucidating cardiovascular phenotaypes employing genome editing of iPS cells
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依托单位:
MAPPING FINE SCALE OLFACTORY SENSORY REPRESENTATIONS IN THE CORTEX
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依托单位:
海外基金