Investigation of dendritic cell activation and function in a murine model of Plasmodium and Schistosoma co-infection

疟原虫和血吸虫混合感染小鼠模型中树突状细胞活化和功能的研究

• 批准号: nhmrc : 567069
• 负责人: Dr Rachel Lundie
• 金额: $ 23.93万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-dendritic-cell-co-infection/116042
• 关键词: Investigation; dendritic; cell; activation; function

Malaria is responsible for over 2 million deaths annually, mainly in sub-Saharan Africa. Importantly, around 1 billion people in malaria endemic areas are infected with parasitic worms, thus malaria and worm co-infections frequently occur. This project will investigate how malaria and worm parasites interact to influence the immune response and clinical outcomes of each other in a mouse infection model. This will provide new strategies for the design of effective treatments in co-endemic areas.

疟疾每年造成200多万人死亡，主要是在撒哈拉以南非洲。重要的是，疟疾流行地区约有10亿人感染寄生蠕虫，因此经常发生疟疾和寄生虫合并感染。该项目将研究疟疾和蠕虫寄生虫如何在小鼠感染模型中相互作用以影响彼此的免疫反应和临床结果。这将为在共同流行地区设计有效的治疗方法提供新的战略。