Clinical Epidemiology and Health Services Research (CEHSR)

临床流行病学和健康服务研究 (CEHSR)

• 批准号: 8889585
• 负责人: KING K. HOLMES
• 金额: $ 18.75万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8889585
• 关键词: AIDS/HIV problem; Address; Applications Grants; Area; Award; Basic Science; Behavioral; Cardiovascular Diseases; Chronic; Chronic Disease; Clinic; Clinical; Clinical Data; Clinical Research; Collaborations; Complement; Data; Data Element; Data Quality; Data Set; Discipline; Disease; Disease Outcome; Enrollment; Epidemiologist; Exclusion Criteria; Feasibility Studies; Funding; Goals; HIV; Health; Health Services; Health Services Research; Individual; Inflammation; Information Systems; Instruction; Kidney Diseases; Link; Liver diseases; Lung; Measures; Mentors; Metabolic Diseases; Neurologic; Observational Study; Online Systems; Organ; Outcome; Pathogenesis; Patients; Prevention; Procedures; Process; Randomized Controlled Trials; Recruitment Activity; Research; Research Personnel; Research Priority; Research Support; Retrovirology; Scientist; Source; Specimen; Standardization; Study Subject; Training; Translational Research; Treatment outcome; United States National Institutes of Health; Universities; Washington; Work; base; behavioral health; clinical care; clinical epidemiology; cohort; comparative effectiveness; compare effectiveness; effectiveness research; improved; inclusion criteria; innovation; meetings; novel strategies; programs; prospective; repository; software development; statistics; treatment strategy

PROJECT SUMMARY (See Instructions): The need for observational HIV clinical research to complement the invaluable information provided by randomized controlled trials has grown tremendously, which is why we established the CFAR Clinical Epidemiology and Health Services Research (CE&HSR) program at the University of Washington (UW) in 1997 and were among the first CFARs in the US to do so. The UW CE&HSR Core pioneered approaches to standardization, content, and integration of clinical HIV data required for HIV/AIDS research and has become a key engine for cohort-based health research locally, nationally, and internationally, which has had tremendous impact on the field and on the clinical care and outcomes of HIV-infected individuals. The UW/FHRC CFAR CE&HSR Core will address the following specific aims: Aim 1. Facilitate Comparative Effectiveness Research to Improve HIV Disease Outcomes: promote and support HIV/AIDS clinical research comparing the effectiveness of treatment strategies for HIV-infected patients in routine clinical care, including the management of serious HIV-associated chronic diseases, such as cardiovascular, renal, and liver disease with the goal of improving HIV disease outcomes. The Core is forming Chronic Disease Study Groups to develop analysis plans for defining and validating data needed to conduct research in the areas of HIV-related pulmonary and neurological complications, cardiovascular, liver and metabolic diseases, and determining the impact of socio-behavioral conditions and HIV-related disparities on clinical outcomes. We will continue to train junior investigators and recruit investigators from other disciplines who are new to HIV research to collaborate in addressing emerging questions regarding HIV/AIDS. Aim 2. Expand the UW HIV Information System (UWHIS): provide a wide range of research expertise and a comprehensive source of prospective, longitudinal patient data capturing rapidly changing HIV treatment and outcomes to support innovative interdisciplinary HIV/AIDS research. We will promote collaboration between clinician researchers, epidemiologists, biostatisticians, basic scientists, socio-behavioral and health services researchers using novel approaches to address the most pressing questions concerning HIV/AIDS treatment and prevention. Aim 3. Facilitate Translational and Basic HIV Research: support translational and basic research aimed at defining the underlying pathogenesis of chronic inflammation in HIV and mechanisms leading to chronic end organ disease by expanding clinical specimens collected on the UW HIV Cohort tracked in the UWHIS linked to patient data and stored in the UW HIV Specimen Repository.

项目总结（见说明）： 对观察性HIV临床研究的需求，以补充随机对照试验提供的宝贵信息已经大大增加，这就是为什么我们于1997年在华盛顿大学（UW）建立了CFAR临床流行病学和卫生服务研究（CE&HSR）计划，并且是美国第一批这样做的CFAR之一。UW CE&HSR核心开创了HIV/AIDS研究所需的临床HIV数据的标准化，内容和整合方法，并已成为当地，国家和国际上基于队列的健康研究的关键引擎，对该领域和临床护理产生了巨大影响。UW/FHRC CFAR CE&HSR核心将解决以下具体目标：目标1。促进比较有效性研究，以改善艾滋病毒疾病的结果：促进和支持艾滋病毒/艾滋病临床研究，比较艾滋病毒感染患者在常规临床护理中的治疗策略的有效性，包括管理严重的艾滋病毒相关慢性疾病，如心血管，肾脏和肝脏疾病，以改善艾滋病毒疾病的结果。核心正在组建慢性病研究小组，以制定分析计划，确定和验证在艾滋病毒相关肺部和神经系统并发症、心血管、肝脏和代谢疾病领域进行研究所需的数据，并确定社会行为状况和艾滋病毒相关差异对临床结果的影响。我们将继续培训初级研究人员，并从其他学科招聘新的艾滋病毒研究人员，以合作解决有关艾滋病毒/艾滋病的新问题。目标2.扩大UW HIV信息系统（UWHIS）：提供广泛的研究专业知识和前瞻性的全面来源，纵向患者数据捕捉迅速变化的艾滋病毒治疗和结果，以支持创新的跨学科艾滋病毒/艾滋病研究。我们将促进临床研究人员、流行病学家、生物统计学家、基础科学家、社会行为和卫生服务研究人员之间的合作，采用新的方法解决有关艾滋病毒/艾滋病治疗和预防的最紧迫问题。目标3。促进转化和基础艾滋病毒研究：支持转化和基础研究，旨在通过扩大在UWHIS中跟踪的UW HIV队列中收集的临床样本，定义艾滋病毒慢性炎症的潜在发病机制和导致慢性终末器官疾病的机制，该样本与患者数据相关联并存储在UW HIV样本库中。