Development of epidermal, wireless sensor tattoos for non-invasive monitoring of biofluid composition

开发表皮无线传感器纹身，用于非侵入性监测生物流体成分

• 批准号: 8980210
• 负责人: Peter Tseng
• 金额: $ 5.6万
• 依托单位: TUFTS UNIVERSITY MEDFORD
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-16 至 2017-09-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8980210
• 关键词: Architecture; Bacteria; Behavior; Biocompatible Materials; Biological; Biological Markers; Blood; Bypass; Cells; Characteristics; Classification; Complex; Consumption; Data; Data Analyses; Data Collection; Detection; Development; Devices; Diet; Electronics; Evolution; Feedback; Film; Fingerprint; Frequencies; Goals; Health; Human body; Ions; Knowledge; Laboratories; Libraries; Link; Machine Learning; Measurement; Measures; Mechanics; Medical Device; Methodology; Microfluidics; Monitor; Nafion; Pattern; Performance; Principal Component Analysis; Public Health; Radio; Radio Waves; Reader; Research Infrastructure; Running; Saliva; Silk; Skin; Sodium; Solutions; Stimulus; Structure; Surface; Sweat; Sweating; System; Tattooing; Testing; Time; Tooth structure; Training; Urea; Validation; Wireless Technology; World Health; bioelectricity; design; electric impedance; enzyme activity; flexibility; glucose monitor; improved; insight; non-invasive monitor; nutrition; public health relevance; real world application; remote sensing; response; saliva composition; sensor; tool; usability

 DESCRIPTION (provided by applicant): Non-invasive medical devices are fast emerging as powerful tools in providing quantitative, simple to parse data in assessing the health and wellness of users. These devices can provide information feedback to users on their state of health, and can potentially provide valuable real-time insight to doctors on the links between user consumption and activity on their respective health. Recently described epidermal electronics / multifunctional tattoos introduced from our lab and others have demonstrated sensing of biopressure, bioelectricity, analyte concentration, bacteria, and more. These structures potentially represent the evolution of wearable devices as they possess a negligible form factor and conform to any surface (such as skin or teeth), minimizing user impact. These devices also bypass more traditional, "wearable" gadgets that often require bulky mechanical fixtures or straps, require complex microfluidic systems or integrated electronics, cannot provide dynamic readout, and cannot be disposed of easily. Dielectric sensors are a class of structures that are able to probe the composition of a biofluid via their impedance spectrum, and can be configured for remote sensing via radio waves. These devices can be composed of isolated, thin film circuits, and are directly amenable to epidermal or tattoo formats. This measurement methodology is inherently tremendously powerful, as it can potentially measure multiple analytes at once by probing multiple resonance peaks, and can potentially be piggybacked onto existing RFID infrastructure for data readout. However, these capabilities have not yet been demonstrated, and under real-world applications dielectric sensors have often proven difficult to use. This is often due to simplistic readout (devices will directly correlate a single metric such s the real value of the impedance at a frequency to a biomarker) and are thus can be sensitive from user to user or to environmental conditions. Herein, the applicant will leverage the expertise and knowledge of the labs of Dr. Omenetto and colleagues to bring practical usability to these dielectric antennas, bridging the gap between laboratory measurement and real-time, and real-world health monitoring applications. The end-goal is to generate disposable, skin and teeth-mounted, dielectric sensors to remotely probe the presence of biomarkers in sweat, saliva, and potentially blood to draw definitive links between user nutrition and their health.

 描述（由申请人提供）：非侵入性医疗设备正在迅速成为评估用户健康和健康状况时提供定量、简单解析数据的强大工具。这些设备可以向用户提供关于其健康状况的信息反馈，并且可以潜在地向医生提供关于用户消费和活动之间的联系的有价值的实时见解。最近描述的表皮电子/多功能纹身从我们的实验室和其他人已经证明了生物压力，生物电，分析物浓度，细菌等的传感。这些结构可能代表了可穿戴设备的发展，因为它们具有可忽略的形状因子，并符合任何表面（如皮肤或牙齿），最大限度地减少了用户的影响。这些设备还绕过了更传统的“可穿戴”小工具，这些小工具通常需要笨重的机械固定装置或带子，需要复杂的微流体系统或集成电子器件，不能提供动态读数，并且不能容易地处理。介电传感器是一类能够通过其阻抗谱探测生物流体的组成的结构，并且可以被配置用于通过无线电波进行遥感。这些设备可以由隔离的薄膜电路组成，并直接适用于表皮或纹身格式。这种测量方法本身就非常强大，因为它可以通过探测多个共振峰来同时测量多个分析物，并且可以搭载到现有的RFID基础设施上进行数据读出。然而，这些能力尚未得到证明，并且在实际应用中，介电传感器通常被证明难以使用。这通常是由于简单化的读出（设备将直接将单个度量（诸如在频率处的阻抗的真实的值）与生物标志物相关联），并且因此可以从用户到用户或对环境条件敏感。在此，申请人将利用Omenetto博士及其同事实验室的专业知识和知识，为这些介质天线带来实际可用性，弥合实验室测量与实时和现实世界健康监测应用之间的差距。最终目标是产生一次性的，皮肤和牙齿安装的介电传感器，以远程探测汗液，唾液和潜在血液中生物标志物的存在，以确定用户营养与健康之间的联系。