Proton Sponge Adhesives, Interfacial Milieu: Molecular Structure-Mechanics

质子海绵粘合剂，界面环境：分子结构力学

• 批准号: 8868097
• 负责人: Jennifer S. Laurence
• 金额: $ 38.94万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8868097
• 关键词: Acids; Address; Adhesions; Adhesives; Adsorption; Affect; Agglutinins; Area; Bacteria; Bacterial Adhesins; Binding; Cell Wall; Chemistry; Clinical; Clinical Data; Clinical Research; Clinical Services; Combinatorial Optimization; Dental; Dental Enamel; Dental Pellicle; Dental Plaque; Dental Research; Dental caries; Dentin; Deterioration; Development; Ecosystem; Engineering; Environment; Enzymes; Failure; Fatigue; Film; Fostering; Fracture; Gingiva; Glycoproteins; Goals; Growth; Human; In Situ; Incidence; Inflammation; Kinetics; Lactic acid; Lead; Link; Liquid substance; Mechanics; Mediating; Methacrylates; Microbial Biofilms; Modeling; Molecular Structure; Molecular Weight; National Institute of Dental and Craniofacial Research; Oral; Oral cavity; Organism; Patients; Porifera; Property; Proteins; Protons; Reaction; Recurrence; Replacement Therapy; Research; Resistance; Role; Saliva; Salivary; Secondary to; Strategic Planning; Streptococcus mutans; Stress; Surface; Testing; Time; Tooth structure; Viscosity; Work; analog; base; cariogenic bacteria; clinically relevant; composite restoration; demineralization; design; improved; interfacial; microorganism; novel; oral biofilm; prevent; pulpal hypersensitivity; restoration; restorative dentistry; seal; tooth surface

DESCRIPTION (provided by applicant): Out of 166 million restorations placed in the U.S., clinical data suggest that >100 million were replacements. Replacement therapy is expected to increase with the growing demand for composite restorations, e.g. as indicated in the 2009-2013 NIDCR strategic plan, dental composites have an average replacement time of 5.7 years. The NIDCR strategic plan stresses the development of longer-lasting restorations and research that explores whether oral biofilms accelerate the degradation of dental composites, leading to secondary decay and restoration failure. The gingival margin of composite restorations is particularly vulnerable to decay and at this margin, the adhesive and its seal to dentin provides the primary barrier between the prepared tooth and the environment. Adhesion of the cariogenic bacterium, Streptococcus mutans, to surfaces in the mouth creates an environment that supports the subsequent attachment and growth of other bacterial species, ultimately forming a micro-ecosystem, i.e., a biofilm. Dental plaque biofilm cannot be eliminated, but the pathogenic impact of the biofilm at the gingival margin could be reduced by engineering novel anti-cariogenic dentin adhesives. We propose a twofold strategy to develop adhesives that (i) limit attachment of the glycoprotein, gp340, that mediates adhesion of S. mutans and (ii) neutralize the acidic micro-environment to prevent demineralization of the adjacent tooth structure. The overall hypothesis of this work is that methacrylate-based adhesives formulated to minimize gp340/S. mutans attachment and to neutralize the acidic micro-environment will provide an enhanced barrier to cariogenesis as compared to the state-of-the-art etch-and-rinse dentin adhesives. Our goal is to show how alterations in the chemistry of methacrylate-based adhesives will lead to predictable changes in material properties (gp340/S. mutans attachment, reaction to lactic acid, mechanical properties) and to optimize features for in situ adhesive/dentin bond formation based on kinetics, fatigue and modeling of interfacial damage. The specific aims are: 1) to synthesize the most promising methacrylate-based adhesives which minimize gp340/S. mutans attachment and neutralize the acidic micro-environment using an iterative combinatorial optimization/synthesis approach; 2) to determine the effect of biologic fouling on degradation of the new dentin adhesives by studying the interaction between the degraded adhesive, gp340 and S. mutans; 3) to test the mechanical and physicochemical properties of the gp340/S. mutans resistant adhesive at the interface with caries-free and caries-affected dentin.

描述（由申请人提供）：在美国放置的1.66亿个修复体中，临床数据显示bb0.1亿个是替换体。替代疗法预计将随着复合材料修复需求的增长而增加，例如，根据2009-2013年NIDCR战略计划，牙科复合材料的平均替代时间为5.7年。NIDCR战略计划强调开发更持久的修复体，并研究口腔生物膜是否会加速牙齿复合材料的降解，导致二次腐烂和修复失败。复合修复体的牙龈边缘特别容易腐烂，在这个边缘，粘合剂及其与牙本质的密封提供了预备牙齿与环境之间的主要屏障。致龋细菌变形链球菌与口腔表面的粘附创造了一个支持其他细菌随后附着和生长的环境，最终形成一个微生态系统，即生物膜。牙菌斑生物膜是无法消除的，但通过工程设计的新型抗龋牙本质粘接剂可以降低龈缘生物膜的致病性。我们提出了一种开发粘合剂的双重策略：(i)限制糖蛋白gp340的附着，gp340介导变形链球菌的粘附；（ii）中和酸性微环境以防止邻近牙齿结构的脱矿。这项工作的总体假设是，甲基丙烯酸酯基粘合剂的配方可以最小化gp340/S。与最先进的蚀刻和冲洗牙本质粘合剂相比，Mutans的附着和中和酸性微环境将提供增强的龋齿发生屏障。我们的目标是展示甲基丙烯酸酯基粘合剂的化学变化如何导致材料性能的可预测变化(gp340/S。改变附着，对乳酸的反应，机械性能)，并基于动力学，疲劳和界面损伤建模来优化原位粘合剂/牙本质键形成的特征。具体目标是：1)合成最有前途的甲基丙烯酸酯基胶粘剂，使gp340/S最小。利用迭代组合优化/合成方法改变附着并中和酸性微环境；2)通过研究降解后的牙本质粘接剂与gp340、变形链球菌的相互作用，确定生物污染对新型牙本质粘接剂降解的影响；3)测试gp340/S的机械和物理化学性能。在无龋齿和受龋齿影响的牙本质的界面上变形抗粘接剂。

项目成果

Visible-Light Initiated Free-Radical/Cationic Ring-Opening Hybrid Photopolymerization of Methacrylate/Epoxy: Polymerization Kinetics, Crosslinking Structure, and Dynamic Mechanical Properties.

• DOI: 10.1002/macp.201400506
• 发表时间: 2015-04
• 期刊: Macromolecular chemistry and physics
• 影响因子: 2.5
• 作者: Ge X;Ye Q;Song L;Misra A;Spencer P
• 通讯作者: Spencer P

Synthesis and evaluation of a novel co-initiator for dentin adhesives: polymerization kinetics and leachables study.

• DOI: 10.1007/s11837-015-1335-6
• 发表时间: 2015-04-01
• 期刊: JOM
• 影响因子: 2.6
• 作者: Ge, Xueping;Ye, Qiang;Song, Linyong;Laurence, Jennifer S.;Spencer, Paulette
• 通讯作者: Spencer, Paulette

Computer-aided Molecular Design of Water Compatible Visible Light Photosensitizers for Dental Adhesive.

• DOI: 10.1016/j.ces.2016.09.033
• 发表时间: 2017-02-23
• 期刊: Chemical engineering science
• 影响因子: 4.7
• 作者: Abedin F;Roughton B;Ye Q;Spencer P;Camarda K
• 通讯作者: Camarda K

Tris(trimethylsilyl)silane as a co-initiator for dental adhesive: Photo-polymerization kinetics and dynamic mechanical property.

Tris（三甲基甲硅烷基）硅烷作为牙齿粘合剂的共同生动剂：照片聚合动力学和动态机械性能。

• DOI: 10.1016/j.dental.2015.10.013
• 发表时间: 2016-01
• 期刊: Dental materials : official publication of the Academy of Dental Materials
• 作者: Song L;Ye Q;Ge X;Misra A;Spencer P
• 通讯作者: Spencer P

Compositional design and optimization of dentin adhesive with neutralization capability.

具有中和能力的牙本质粘合剂的成分设计与优化。

• DOI: 10.1016/j.jdent.2015.06.008
• 发表时间: 2015
• 期刊: Journal of dentistry
• 影响因子: 4.4
• 作者: Song,Linyong;Ye,Qiang;Ge,Xueping;Spencer,Paulette
• 通讯作者: Spencer,Paulette