Effects of environmental contamination on gene copy number variation: Molecular b

环境污染对基因拷贝数变异的影响:分子b

基本信息

  • 批准号:
    8446511
  • 负责人:
  • 金额:
    $ 35.53万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-08-01 至 2015-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Recent studies indicate copy number variation accounts for the majority of the genetic variation observed in the human populations and have uncovered strong associations between copy number variation (CNV) and disease, including complex phenotypes. However, the environmental contributions to CNV remain unknown, in part because the magnitude of CNV has only been realized with the growing number of fully sequenced genomes and because there are few animal models available for environmental genomics studies, which seek to understand how genome structure and function evolve in response to environmental change. Accordingly, our proposal employs studies using the recently added and ideal NIH model organism, Daphnia, to test the central hypothesis that exposure to environmental contaminants increase the rate of mutations giving rise to CNV, and that this variation has functional consequences on gene expression, phenotype, and fitness and population structure. Mutation accumulation (MA) lines derived in the absence and presence of cadmium will be used to define the spectra of CNV and measure the per generation rate at which they spontaneously arise in individuals. Three independently replicated, cadmium-adapted populations will be surveyed for CNV, gene- expression assessed, and fitness assayed to characterize the magnitude, distribution, functional consequences, and evolutionary path of CNV. Finally, quantitative trait loci experiments will be conducted to determine the functional significance of CNV by establishing cause and effect relationships between copy number variants and phenotype. Collectively, these studies will quantitatively assess whether environmental exposure affects the risk for spontaneous CNV, and do so in context of their contributions to individual health parameters that influence tolerance (i.e., adaptation, susceptibility) and disease. Answers to these questions have profound implications for the long-term health of human populations that are living longer and doing so in increasingly mutagenic environments.
描述(由申请人提供):最近的研究表明,拷贝数变异占人群中观察到的大部分遗传变异,并且发现拷贝数变异(CNV)与疾病(包括复杂表型)之间存在强相关性。然而,环境对CNV的贡献仍然是未知的,部分原因是CNV的大小仅随着全测序基因组数量的增加而被认识到,并且因为很少有动物模型可用于环境基因组学研究,其试图了解基因组结构和功能如何响应环境变化而进化。因此,我们的建议采用研究使用最近添加的和理想的NIH模式生物,水蚤,以测试的中心假设,暴露于环境污染物增加的突变率引起CNV,这种变化有功能的基因表达,表型和健身和人口结构的后果。在不存在和存在镉的情况下衍生的突变累积(MA)系将用于定义CNV的光谱,并测量它们在个体中自发出现的每代速率。将调查三个独立复制的镉适应人群的CNV,评估基因表达,并测定适应性,以表征CNV的大小、分布、功能后果和进化路径。最后,将进行数量性状基因座实验,通过建立拷贝数变异和表型之间的因果关系来确定CNV的功能意义。总的来说,这些研究将定量评估环境暴露是否影响自发性CNV的风险,并在其对影响耐受性的个体健康参数(即,适应、易感性)和疾病。这些问题的答案对人类的长期健康有着深远的影响,人类的寿命更长,而且在越来越多的诱变环境中也是如此。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Joseph R. Shaw其他文献

Biomarker-enhanced VTE risk stratification in ambulatory patients with cancer.
生物标志物增强的癌症门诊患者 VTE 风险分层。
  • DOI:
    10.1016/j.thromres.2020.09.035
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    7.5
  • 作者:
    Joseph R. Shaw;Vaibhav Kumar;R. Mallick;M. Carrier;A. Ilich;N. Key;P. Wells
  • 通讯作者:
    P. Wells
D-dimer enhances risk targeted thromboprophylaxis in ambulatory cancer patients.
D-二聚体增强了门诊癌症患者的风险靶向血栓预防。
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Vaibhav Kumar;Joseph R. Shaw;N. Key;A. Ilich;R. Mallick;P. Wells;M. Carrier
  • 通讯作者:
    M. Carrier
Activated prothrombin complex concentrates for direct oral anticoagulant-associated bleeding or urgent surgery: Hemostatic and thrombotic outcomes
  • DOI:
    10.1016/j.thromres.2020.06.044
  • 发表时间:
    2020-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    Joseph R. Shaw;Marc Carrier;Dar Dowlatshahi;Santanu Chakraborty;Melanie Tokessy;Hakan Buyukdere;Lana A. Castellucci
  • 通讯作者:
    Lana A. Castellucci
Prothrombin complex concentrate for direct factor Xa inhibitor-associated bleeding or before urgent surgery
  • DOI:
    10.1016/j.thromres.2024.109172
  • 发表时间:
    2024-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    Joseph R. Shaw;Abdulrahman Abdulaziz Almujalli;Yan Xu;Jerrold H. Levy;Sam Schulman;Deborah Siegal;Dar Dowlatshahi;Melanie Tokessy;Hakan Buyukdere;Marc Carrier;Lana A. Castellucci
  • 通讯作者:
    Lana A. Castellucci
Coagulation assays and direct oral anticoagulant levels among patients having an elective surgery or procedure
接受择期手术或手术的患者的凝血测定和直接口服抗凝剂水平
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    10.4
  • 作者:
    Joseph R. Shaw;Na Li;Joanne Nixon;K. Moffat;A. Spyropoulos;S. Schulman;J. Douketis
  • 通讯作者:
    J. Douketis

Joseph R. Shaw的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Joseph R. Shaw', 18)}}的其他基金

Assessing Environmental Exposures to Persistent Organic Pollutants in Assisted Living Facilities
评估辅助生活设施中持久性有机污染物的环境暴露
  • 批准号:
    10022518
  • 财政年份:
    2019
  • 资助金额:
    $ 35.53万
  • 项目类别:
Establishing a Network of Skilled BD2K Practitioners: The Summer Workshop on Population-Scale Genomic Studies of Environmental Stress
建立熟练的 BD2K 从业者网络:环境压力人口规模基因组研究夏季研讨会
  • 批准号:
    9043623
  • 财政年份:
    2015
  • 资助金额:
    $ 35.53万
  • 项目类别:
Effects of environmental contamination on gene copy number variation: Molecular b
环境污染对基因拷贝数变异的影响:分子b
  • 批准号:
    7984619
  • 财政年份:
    2010
  • 资助金额:
    $ 35.53万
  • 项目类别:
Effects of environmental contamination on gene copy number variation: Molecular b
环境污染对基因拷贝数变异的影响:分子b
  • 批准号:
    8247015
  • 财政年份:
    2010
  • 资助金额:
    $ 35.53万
  • 项目类别:
Effects of environmental contamination on gene copy number variation: Molecular b
环境污染对基因拷贝数变异的影响:分子b
  • 批准号:
    8641358
  • 财政年份:
    2010
  • 资助金额:
    $ 35.53万
  • 项目类别:
Effects of environmental contamination on gene copy number variation: Molecular b
环境污染对基因拷贝数变异的影响:分子b
  • 批准号:
    8118787
  • 财政年份:
    2010
  • 资助金额:
    $ 35.53万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 35.53万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 35.53万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 35.53万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 35.53万
  • 项目类别:
    Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 35.53万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 35.53万
  • 项目类别:
    Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 35.53万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 35.53万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 35.53万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 35.53万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了