Pilot and definitive studies to evaluate Insertional Mutagenesis

评估插入诱变的试点和最终研究

• 批准号: 8655051
• 负责人: LU TAYLOR
• 金额: $ 42万
• 依托单位: BATTELLE CENTERS/PUB HLTH RES & EVALUATN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-03 至 2014-02-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8655051
• 关键词: Adverse effects; Alleles; Amino Acids; Architecture; Bone Marrow; Bone Marrow Transplantation; Cells; Chemicals; Contracts; Control Animal; DNA Sequence; Data; Data Set; Development; Dose; Enhancers; Ensure; Environmental Exposure; Evaluation; Exposure to; Future; Gagging; Genome; Goals; Hazard Identification; Hazardous Chemicals; Health; Heightened Cancer Risk; Hematopoietic stem cells; Human; Insertional Mutagenesis; Location; Modeling; Modification; Mus; Mutation; National Toxicology Program; Open Reading Frames; Outcome; Pilot Projects; Plasmids; Positioning Attribute; Process; Property; Public Domains; Retroviral Vector; Risk Assessment; Risk Factors; Safety; Site; Specific qualifier value; Testing; Toxic effect; Toxicity Tests; Transgenes; United States Food and Drug Administration; cellular transduction; design; disorder prevention; enhanced green fluorescent protein; leukemia; promoter; public health research; sound; vector

The goal of this contract is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. These contracts contribute to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing characterization of the chemicals studied, confirmation of the dose levels administered, and internal dose determinations. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals.

该合同的目的是为国家毒理学计划（NTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要进行适当的化学分析，以确保在毒性研究中，试验种属以规定的剂量浓度暴露于规定的化学品。这些合同通过提供所研究化学品的特征、所施用剂量水平的确认和内部剂量确定，有助于毒性研究提供癌症风险升高沿着其他毒理学结果的证据。这些信息对于评价毒性试验和得出关于研究化学品在试验种属中的潜在毒性的合理科学结论至关重要，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。根据该合同提供的内部剂量信息，可以对人类进行推断，以便公众能够充分了解接触所研究的化学品所产生的风险因素。