Project 1

项目1

• 批准号: 8933165
• 负责人: BLOSSOM A DAMANIA
• 金额: $ 8.1万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8933165
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Africa South of the Sahara; Anti-Retroviral Agents; Cancer Burden; Cancer Control; Caring; Clinic; Clinical Research; Collaborations; Data; Data Linkages; Data Quality; Data Set; Databases; Diagnosis; Doctor of Philosophy; Ensure; Epidemic; Epidemiologic Studies; Epidemiology; Flowers; Frequencies; General Population; Goals; HIV; Health; Herpesviridae; Hospitals; Incidence; Individual; International; Kaposi Sarcoma; Link; Lymphoma; Malawi; Malignant Neoplasms; Measures; Medicine; Methods; Monitor; Monograph; North Carolina; Patients; Persons; Population; Prevention; Principal Investigator; Registries; Research; Research Infrastructure; Research Project Grants; Resources; Risk; Risk Factors; Running; South Africa; System; Time; Trust; Universities; Update; Work; antiretroviral therapy; base; cancer risk; cohort; college; follow-up; geographic population; implementation science; neoplasm registry; population based; professor; scale up; success; trend; tumor; virology

This application is to establish the UNC-Malawi Cancer Consortium (UNC-MCC), to develop capacity and conduct high-impact research focused on HIV-associated cancers. The consortium builds on longstanding collaborations between the University of North Carolina at Chapel Hill.(UNC-CH), Lighthouse Trust, Malawi Ministry of Health, and University of Malawi College of Medicine. These partnerships have resulted in internationally recognized contributions for HIV care and prevention in sub-Saharan Africa. This infrastructure can now be leveraged for HIV-associated malignancies. UNC-MCC is focused on the herpesvirus-associated cancers, Kaposi sarcoma (KS), and lymphoma. Our consortium will be led by three principal investigators with highly complementary expertise (Satish Gopal MD, clinical research; Sam Phiri PhD, implementation science; Blossom Damania PhD, virology). The first of three research projects being undertaken by UNC-MCC is an HIV-cancer record linkage study using the Malawi National Cancer Registry (MNCR). The project is led by three co-PIs, Drs. Charles Dzamalala (MNCR Director), Kennedy Malisita (Director, Antiretroviral Therapy Clinic, Queen Elizabeth Central Hospital), and Andy Olshan (Professor and Chair of the UNC-CH Department of Epidemiology). The project utilizes a unique set of resources within Malawi, including a population-based national cancer registry which is one of only four from sub-Saharan Africa to be included in the current WHO cancer incidence monograph, and HIV cohorts with detailed, longitudinal characterization of large numbers of patients. Combining these resources presents a rare opportunity to understand how cancer risk may be changing in the antiretroviral (ART) therapy, including for herpesvirus-associated cancers. This is still largely unknown in sub-Saharan Africa, and declines in incidence have not yet been observed in Malawi even after ART scale-up began 2004. The study will be conducted using probabilistic matching methods to link large national datasets, with technical assistance from the International Epidemiologic Databases to Evaluate AIDS (IeDEA) network, who have sponsored prior record linkage studies in South Africa. This work is anticipated to result in one of the best epidemiologic resources in the region for HIV-related malignancies research, to better understand current trends, and assist in prioritization of resources within Malawi based on high-quality local data.

该申请旨在建立北卡罗来纳大学-马拉维癌症联盟 (UNC-MCC)，以发展能力并开展针对艾滋病毒相关癌症的高影响力研究。该联盟建立在北卡罗来纳大学教堂山分校 (UNC-CH)、灯塔信托基金、马拉维卫生部和马拉维大学医学院之间的长期合作基础上。这些伙伴关系为撒哈拉以南非洲的艾滋病毒护理和预防做出了国际公认的贡献。该基础设施现在可用于治疗与艾滋病毒相关的恶性肿瘤。 UNC-MCC 专注于疱疹病毒相关癌症、卡波西肉瘤 (KS) 和淋巴瘤。我们的联盟将由三位具有高度互补专业知识的主要研究人员领导（Satish Gopal 医学博士，临床研究；Sam Phiri 博士，实施科学；Blossom Damania 博士，病毒学）。 UNC-MCC 正在进行的三个研究项目中的第一个是利用马拉维国家癌症登记处 (MNCR) 进行的艾滋病毒与癌症记录关联研究。该项目由三位联合 PI 博士领导。 Charles Dzamalala（MNCR 主任）、Kennedy Malisita（伊丽莎白女王中心医院抗逆转录病毒治疗诊所主任）和 Andy Olshan（UNC-CH 流行病学系教授兼系主任）。该项目利用马拉维境内一套独特的资源，包括基于人口的国家癌症登记处（这是撒哈拉以南非洲地区仅有的四个被纳入当前世卫组织癌症发病率专着的国家癌症登记处之一），以及对大量患者进行详细纵向特征描述的艾滋病毒队列。结合这些资源提供了一个难得的机会来了解抗逆转录病毒 (ART) 治疗中癌症风险如何变化，包括疱疹病毒相关癌症。这在撒哈拉以南非洲地区仍然是未知数，即使在 2004 年开始扩大抗逆转录病毒治疗后，马拉维尚未观察到发病率下降。这项研究将使用概率匹配方法来链接大型国家数据集，并得到国际艾滋病评估流行病学数据库 (IeDEA) 网络的技术援助，该网络曾赞助过南非先前的记录关联研究。这项工作预计将成为该地区艾滋病毒相关恶性肿瘤研究的最佳流行病学资源之一，以更好地了解当前趋势，并根据高质量的当地数据协助马拉维境内资源的优先排序。