Analytics

该申请旨在建立unc -马拉维癌症联盟（UNC-MCC），以发展能力并开展以艾滋病毒相关癌症为重点的高影响力研究。该联盟建立在北卡罗来纳大学教堂山分校（UNC-CH）、灯塔信托基金、马拉维卫生部和马拉维大学医学院（COM）之间的长期合作基础上。这些伙伴关系为撒哈拉以南非洲的艾滋病毒护理和预防作出了国际公认的贡献。这种基础设施现在可用于治疗与艾滋病毒相关的恶性肿瘤。UNC-MCC专注于疱疹病毒相关的癌症、卡波西肉瘤（KS）和淋巴瘤。我们的联盟将由三位具有高度互补专业知识的主要研究者领导（Satish Gopal医学博士，临床研究；Sam Phiri博士，实施科学；Blossom Damania博士，病毒学）。该联盟的应用分析核心（Analytics Core）将由Nora Rosenberg博士（UNC项目-马拉维）和Hannock Tweya MPH （Lighthouse Trust）领导。这两家机构都设在马拉维，在研究设计、数据分析和手稿撰写方面有着良好的记录，并在支持国内研究活动方面发挥了关键作用。这是一个可选的核心项目，由合作伙伴优先考虑为马拉维调查人员提供分析支持和培训，目前这方面还不够。支持分析核心合作项目的是马拉维和UNC-CH的一组已建立的教师，他们已被招募在财团合作伙伴优先考虑的关键领域提供指导，并根据具体项目的要求提供指导。“分析核心”将专注于以下目标：(1)进行分析，以支持三个拟议的研究项目；(2)通过各种培训活动在马拉维建立分析能力；(3)传播财团赞助的研究结果。该核心的活动将与该联盟的其他行政和指导核心密切合作，并将协助建设人类研究能力和最大限度地提高UNC-MCC的科学产出。

This application is to establish the UNC-Malawi Cancer Consortium (UNC-MCC), to develop capacity and conduct high-impact research focused on HIV-associated cancers. The consortium builds on longstanding collaborations between the University of North Carolina at Chapel Hill (UNC-CH), Lighthouse Trust, Malawi Ministry of Health, and University of Malawi College of Medicine (COM). These partnerships have resulted in internationally recognized contributions for HIV care and prevention in sub-Saharan Africa. This infrastructure can now be leveraged for HIV-associated malignancies. UNC-MCC is focused on the herpesvirus-associated cancers, Kaposi sarcoma (KS), and lymphoma. Our consortium will be led by three principal investigators with highly complementary expertise (Satish Gopal MD, clinical research; Sam Phiri PhD, implementation science; Blossom Damania PhD, virology). The Applied Analytics Core (Analytics Core) for the consortium will be led by Nora Rosenberg PhD (UNC Project-Malawi) and Hannock Tweya MPH (Lighthouse Trust). Both are based in Malawi with strong track records in study design, data analysis, and manuscript writing, and have played key roles in supporting in-country research activities. This is an optional core prioritized by consortium partners to provide analysis support and training to Malawian investigators, which is currently insufficient. Supporting the Analytics Core co-PIs are an established group of faculty in Malawi and at UNC-CH, who have been enlisted to provide mentorship in key areas prioritized by consortium partners, and as required for the specific projects proposed. The Analytics Core will be focused on the following aims: (1) conducting analyses to support the three proposed research projects; (2) building analytic capacity within Malawi through various training activities; and (3) disseminating findings from consortium-sponsored research. The core's activities will take place in close collaboration with the other administrative and mentoring cores for the consortium, and will assist in building human research capacity and maximizing scientific outputs from UNC-MCC.