Supplement: The Association Between Stigma and Wellbeing among Kaposi sarcoma and Lymphoma Patients in Malawi

补充：马拉维卡波西肉瘤和淋巴瘤患者的耻辱与健康之间的关系

• 批准号: 10844951
• 负责人: BLOSSOM A DAMANIA
• 金额: $ 17.22万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-13 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10844951
• 关键词: AIDS Malignancy Consortium; AIDS clinical trial group; AIDS related cancer; AIDS-Related Lymphoma; Achievement; Acquired Immunodeficiency Syndrome; Address; Adult; Africa; Africa South of the Sahara; African; Award; Biological Markers; Biopsy; Cancer Hospital; Cancer Patient; Caring; Characteristics; Clinical; Clinical Research; Clinical Trials; Collaborations; Communicable Diseases; Comprehensive Cancer Center; Continuity of Patient Care; Crystallization; Data; Eligibility Determination; Enrollment; Epidemic; Flowers; Future; Goals; Grant; HIV; Health; Hospitals; Individual; Institution; International; Intervention; Kaposi Sarcoma; Knowledge; Lead; Leadership; Lymphoma; Malawi; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Measures; Medicine; Mental Health; Molecular; Morbidity - disease rate; Newly Diagnosed; North Carolina; Outcome; Parents; Patient-Focused Outcomes; Patients; Personal Satisfaction; Persons; Policies; Positioning Attribute; Prevalence; Prognosis; Qualifying; Qualitative Research; Quality of life; Recurrence; Research; Research Infrastructure; Research Personnel; Research Project Grants; Science; Site; South Africa; Surveys; Survival Rate; Training; Training and Infrastructure; Translational Research; Trust; UNC Lineberger Comprehensive Cancer Center; United States National Institutes of Health; Universities; anticancer research; cancer care; career; clinical research site; cohort; college; combat; data sharing; detection method; experience; global health; high risk; improved; innovation; insight; interest; internalized stigma; intersectionality; low and middle-income countries; mortality; next generation; oncology program; programs; progression risk; prospective; resilience; response; screening; social stigma; translational impact; treatment and outcome; tumor

ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 23-036. Stigma hampers the cancer care continuum, leading to delayed presentation to care, elevated morbidity and mortality, and reduced quality of life, particularly for patients with HIV-associated cancers. Qualitative research has elucidated the lived experience of stigma among cancer patients and the adverse impact of this stigma on mental health, self-isolation and engagement in care. However, there remains a gap in quantifying the prevalence and distribution of cancer-related stigma and its impact on health-related outcomes for patients with HIV-associated cancers. In response, we are currently developing and validating measures of enacted, anticipated, internalized stigma in Malawi (P30CA042014-33S5, Lead Kimani). With this supplement, the overall goal is to embed these new cancer stigma measures in existing cohorts of cancer patients in Malawi in order to better understand the prevalence and impact of cancer stigma in an African public cancer hospital. Our long-term goal is to use the results from this study to develop R01-level grants for targeted, multi-level interventions to address cancer stigma in Africa and ultimately improve cancer outcomes. In this proposed supplement, we will build on the parent award (U54CA254564, PI Damania) by leveraging the U54 prospective Kaposi sarcoma (KS) and lymphoma cohorts to explore the experience of cancer-related stigma, its impact on clinical outcomes, and its intersection with HIV stigma. Specifically, we will survey newly diagnosed adult patients with biopsy-proven KS or lymphoma, who are receiving or eligible for active cancer care, and enrolled in the parent study to measure cancer and HIV stigma and abstract cancer and patient data from the U54 routine study assessments. We will then quantify the prevalence of cancer stigma among KS and lymphoma patients in Malawi (Aim 1). We will additionally identify key cancer (characteristics, treatment and outcomes) and patient (quality of life, mental health, resilience) factors correlated with cancer stigma, and assess the intersectionality of HIV and cancer stigma (Aim 2). Ultimately, this innovative research will generate findings that will stimulate and strengthen global cancer stigma, build local capacity to conduct cancer stigma research, and lay the ground-work for future R01 proposals to implement and evaluated multi-level interventions that address cancer stigma in Africa and ultimately improve cancer care and outcomes.

抽象的 该申请是为了响应特殊利益通知（NOSI）而提交 23-036。污名阻碍了癌症护理的连续性，导致延迟的表现升高，升高 发病率和死亡率，以及生活质量降低，特别是对于艾滋病毒相关癌症患者。 定性研究阐明了癌症患者的污名和不良污名的生活经验 这种污名对心理健康，自我隔离和护理参与的影响。但是，仍然存在差距 量化癌症相关污名的患病率和分布及其对与健康相关结果的影响 适用于HIV相关癌症的患者。作为回应，我们目前正在制定和验证 在马拉维（P3SCA042014-33S5，铅木尼）制定，预期的，内部的污名。有了这种补充， 总体目的是将这些新的癌症污名测量嵌入马拉维的现有癌症患者中 为了更好地了解非洲公共癌症医院中​​癌症污名的患病率和影响。 我们的长期目标是利用这项研究的结果来为有针对性的多层次开发R01级赠款 解决非洲癌症污名并最终改善癌症结局的干预措施。在此提议中 补充，我们将通过利用U54的预期来建立父母奖（U54CA254564，PI Damania） Kaposi肉瘤（KS）和淋巴瘤队列以探索与癌症相关的污名的经历，其影响 临床结果及其与HIV污名的交集。具体来说，我们将调查新诊断的成人 经过活检的KS或淋巴瘤患者，他们接受或有资格接受主动癌症护理的患者 在父母的研究中，用于测量癌症和HIV污名和抽象癌症以及来自U54的患者数据 常规研究评估。然后，我们将量化KS和淋巴瘤中癌症污名的患病率 马拉维的患者（AIM 1）。我们还将确定关键癌症（特征，治疗和结果） 和患者（生活质量，心理健康，韧性）因素与癌症污名相关，并评估 艾滋病毒和癌症污名的交叉性（AIM 2）。最终，这项创新的研究将产生调查结果 这将刺激和加强全球癌症的污名，建立局部进行癌症污名研究的能力， 并为未来的R01提案提供基础，以实施和评估多层次干预措施 应对非洲的癌症污名，并最终改善癌症护理和结果。

项目成果

Impact of Antiretroviral Therapy on Cancer Treatment Outcomes among People Living with HIV in Low- and Middle-Income Countries: a Systematic Review.

• DOI: 10.1007/s11904-021-00542-5
• 发表时间: 2021-04
• 期刊: Current HIV/AIDS reports
• 影响因子: 4.6

Update on pathology laboratory development and research in advancing regional cancer care in Malawi.

• DOI: 10.3389/fmed.2024.1336861
• 发表时间: 2024
• 期刊: FRONTIERS IN MEDICINE
• 影响因子: 3.9
• 作者: Brownlee, Amy J.;Dewey, Morgan;Chagomerana, Maganizo B.;Tomoka, Tamiwe;Mulenga, Maurice;Khan, Shiraz;Kampani, Coxcilly;Chimzimu, Fred;Gastier-Foster, Julie M.;Westmoreland, Kate D.;Ozuah, Nmazuo W.;Krysiak, Robert;Malamba-Banda, Chikondi;Painschab, Matthew S.;Gopal, Satish;Fedoriw, Yuri
• 通讯作者: Fedoriw, Yuri

Case report: Multicentric Castleman disease as a manifestation of immune reconstitution inflammatory syndrome in Malawi.

病例报告：多中心卡斯尔曼病是马拉维免疫重建炎症综合征的一种表现。

• DOI: 10.3389/fonc.2022.969135
• 发表时间: 2022
• 期刊: Frontiers in oncology
• 影响因子: 4.7

The role of telepathology in improving cancer diagnostic and research capacity in sub-Saharan Africa.

• DOI: 10.3389/fmed.2022.978245
• 发表时间: 2022
• 期刊: Frontiers in medicine
• 影响因子: 3.9

Letters to the Editor Low Rates of Side Effects in Paclitaxel Chemotherapy for Kaposi Sarcoma and Feasibility of Treatment in Outpatient ART Clinic Settings in Malawi.

致编辑的信 紫杉醇化疗卡波西肉瘤的副作用发生率低，以及马拉维门诊 ART 诊所治疗的可行性。

• DOI: 10.1097/qai.0000000000003393
• 发表时间: 2024
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Rambiki,Ethel;Rambiki,Kelvin;Khalani,Jennipher;Huwa,Jacquiline;Wallrauch,Claudia;Heller,Tom;Painschab,Matthew
• 通讯作者: Painschab,Matthew