Neural encoding of reward and safety

奖励和安全的神经编码

• 批准号: 8851860
• 负责人: MICHAEL A MCDANNALD
• 金额: $ 24.26万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8851860
• 关键词: American; Amygdaloid structure; Animals; Area; Behavior; Behavioral; Brain; Cues; Decision Making; Drug Costs; Electrodes; Event; Fright; Functional disorder; Illicit Drugs; Impairment; Implant; Lead; Learning; Left; Lesion; Methods; Neurosciences; Outcome; Phase; Psychological reinforcement; Rattus; Research; Rewards; Role; Safety; Shock; Signal Transduction; Training; Ventral Striatum; addiction; neuromechanism; neurotoxic; novel; reinforcer; relating to nervous system; research study

In a dangerous world, the ability to predict safety is paramount. Impairments in predicting safety would lead one to behave as if danger was ever present; while hyperfunction of this predictive capacity would lead one to behave is if danger was nonexistent. Given the shared, positive significance of reward and safety it is hypothesized that reward prediction and safety prediction share a common neural encoding. The basolateral amygdala (BLA) and VS are two brain areas implicated in signaling reward prediction. The objective of the ROO phase of the proposal is to uncover roles for the BLA and VS in safety; learning driven by the omission of aversive events. To this end neurotoxic lesions will be used to describe contributions of the BLA and VS to safety prediction through conditioned inhibition of Pavlovian fear. Single-unit recording will then be used to (1) examine BLA and VS neural activity supporting safety prediction and (2) compare activity supporting safety prediction to activity supporting reward prediction.

在一个危险的世界里，预测安全的能力至关重要。在预测安全性方面的缺陷将导致 一个人表现得好像危险永远存在;而这种预测能力的过度功能会导致一个人 就是没有危险考虑到奖励和安全的共同的积极意义， 假设奖励预测和安全预测共享共同的神经编码。基底外侧 杏仁核（BLA）和VS是涉及信号奖励预测的两个大脑区域。的目的 该提案的ROO阶段旨在揭示BLA和VS在安全方面的作用;由遗漏驱动的学习 令人厌恶的事件。为此，将使用神经毒性病变来描述BLA和VS的贡献 通过条件性抑制巴甫洛夫恐惧的安全预测。然后将使用单个单元记录 （1）检查支持安全预测的BLA和VS神经活动，（2）比较支持安全预测的活动 安全预测到支持奖励预测的活动。