Biomarkers of Infertility

不孕不育的生物标志物

• 批准号: 8644655
• 负责人: Anne Zweifel Steiner
• 金额: $ 50.65万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8644655
• 关键词: Address; Age; Age of Onset; Aging; Anxiety; Assisted Reproductive Technology; Awareness; Biological Markers; Characteristics; Clinical; Cohort Studies; Coitus; Collection; Communities; Conceptions; Contraceptive methods; Data; Data Collection; Delayed Childbearing; Enrollment; Fertility; Follicle Stimulating Hormone; Future; General Population; Goals; Health behavior; Home environment; Hormones; Human Resources; Individual; Infertility; Institution; Intake; Internet; Lead; Length; Live Birth; Marketing; Measures; Menopause; Menstrual cycle; Methods; Modeling; Monitor; Online Systems; Oocytes; Outcome; Outcome Measure; Ovarian; Participant; Population; Pregnancy; Pregnancy Outcome; Pregnancy Tests; Pregnancy loss; Probability; Prospective Studies; Protocols documentation; Questionnaires; Recording of previous events; Reporting; Reproductive History; Research; Research Infrastructure; Risk; Sensitivity and Specificity; Serum; Spontaneous abortion; Surrogate Endpoint; System; Testing; Time; Training; Ultrasonography; Urine; Woman; age related; base; cohort; cost; data management; demographics; diaries; experience; follow-up; improved; innovation; meetings; parity; predictive modeling; proliferative phase Menstrual cycle; public health relevance; reproductive; toxicant; urinary

DESCRIPTION (provided by applicant): In the current era women often delay attempts to conceive to their thirties and forties, ages associated with higher rates of infertility due to reproductive aging. Despite variability in the age of onset of infertility, no validated markers exist to monitor an individual woman's fertility. The objective of this project is to examine the ability of markers of ovarian aging to predict infertility due to reproductive aging, with the long term goal to develop a model that projects individual loss of reproductive potential. We hypothesize that markers of ovarian aging are associated with natural fecundability (probability of conception per menstrual cycle), predictive of infertility, and associated with the probability of live birth. The proposed study will enroll 750 women from the community, who desire to conceive, and obtain baseline measures of ovarian aging: early follicular phase serum follicle stimulating hormone (FSH) and anti-m|llerian hormone (AMH). Participants will be actively followed throughout their attempts to conceive over the following twelve months. During that time, women will conduct standardized pregnancy testing and complete a daily and monthly diary for collection of detailed exposure data. Pregnancy follow-up will include ultrasound assessment for viability and a pregnancy outcome report. These methods will allow us to address our primary research aims: 1) Establish the marker of ovarian aging that best predicts infertility. To address this aim we will determine a) measures of association between FSH (in urine and serum) and AMH and lack of conception at 6 and 12 months and b) test characteristics (e.g. sensitivity & specificity) of each marker; 2) Develop a predictive model for age-related infertility, incorporating demographics, reproductive history, and markers of ovarian aging; and 3) Generate preliminary estimates of the association between markers of ovarian aging and miscarriage. Our study is innovative in its use of a population of unproven reproductive potential with previous access to contraception and at risk for reproductive aging. Results from this research, combined with research by others, will allow women to predict their current and future reproductive potential, ultimately allowing them more reproductive control.

描述（由申请人提供）：在当今时代，女性经常将怀孕尝试推迟到三十多岁和四十多岁，这个年龄与由于生殖衰老而导致的不孕不育率较高相关。尽管不孕症发病年龄的变化，没有有效的标志物存在监测个别妇女的生育能力。该项目的目的是研究卵巢衰老标志物预测生殖衰老所致不孕症的能力，长期目标是开发一种预测个体生殖潜力丧失的模型。我们假设卵巢老化的标志物与自然受孕能力（每个月经周期的受孕概率）相关，预测不孕症，并与活产概率相关。这项研究将从社区招募750名希望怀孕的妇女，并获得卵巢衰老的基线指标：卵泡早期血清促卵泡激素（FSH）和抗-M抗体。|勒氏管激素（AMH）。在接下来的12个月里，参与者将在他们尝试怀孕的整个过程中得到积极的跟踪。在此期间，妇女将进行标准化的妊娠试验，并完成每日和每月日记，以收集详细的暴露数据。妊娠随访将包括生存能力的超声评估和妊娠结局报告。这些方法将使我们能够解决我们的主要研究目标：1）建立最能预测不孕症的卵巢衰老标志物。为了实现这一目标，我们将确定a）FSH与6个月和12个月时的（尿液和血清中）和AMH以及缺乏受孕和B）测试特征2）开发与年龄相关的不孕症的预测模型，结合人口统计学、生殖史和卵巢衰老的标志物;和3）产生卵巢老化标记物和流产之间的关联的初步估计。我们的研究是创新的，它使用了未经证实的生殖潜力的人口，以前获得避孕和生殖老化的风险。这项研究的结果，结合其他人的研究，将使妇女能够预测她们目前和未来的生殖潜力，最终使她们能够更多地控制生殖。