Time to Conceive

描述（由申请人提供）：试图怀孕的夫妇在一年内大约有七分之一的机会不育。不幸的是，目前还没有经过验证的标记物来预测开始或延迟生殖过程的夫妇未来的不孕症。尽管支持证据有限，但卵巢老化的标志物正在医生办公室和商业家庭套件中测量，作为评估妇女生育能力的方法。我们的长期目标是检查卵巢老化标志物预测一般人群不孕症的能力。这项小型探索性研究的目的是确定在生育潜力未知的育龄人群中，卵巢老化标志物与生育力（每个周期的受孕概率）相关的程度。这项研究的结果将用于选择未来更大队列中预测测试的标记物的数量，时间和选择。这项研究将从社区招募100名希望怀孕的妇女，并获得卵巢衰老的基线指标：卵泡早期血清促卵泡激素、卵泡刺激素B和抗苗勒管激素。在接下来的六个月里，参与者将在他们尝试怀孕的整个过程中受到积极的关注。在此期间，女性将在每个周期的早期卵泡期收集尿液用于FSH测量，每个周期进行最多两次家庭妊娠试验用于标准化妊娠测定，并完成最多三个月经周期的每日日记以收集详细的暴露数据。这些方法将使我们能够解决我们的主要研究目标：（1）产生受精能力和卵巢衰老标志物之间的关联的初步估计和（2）确定个体卵巢衰老标志物的周期与周期的变化。拟议研究的主要工具包括基于网络的日记系统、计算机辅助访谈、数据管理和质量控制系统以及经验丰富的工作人员，这些工具已经到位，确保了可行性。一个简单、有效的生殖潜力测量方法对正在考虑开始或推迟生育的妇女有很大的好处。鉴于未经证实的家庭泌尿套件已经上市，一项前瞻性研究，以确定他们的能力，预测生育能力和生育能力的一般人群是必不可少的。公共卫生相关性：试图怀孕的夫妇在一年内大约有七分之一的机会不育，导致严重的痛苦和焦虑。一个简单、有效的生殖潜力测量方法对正在考虑开始或推迟生育的妇女将有很大的好处。鉴于未经证实的家庭尿液“生育力测试”试剂盒已经上市，一项前瞻性研究，以确定他们的能力，预测生育能力和生育能力的一般人口是必要的。

DESCRIPTION (provided by applicant): Couples attempting to conceive have approximately a 1 in 7 chance of being infertile at one year. Unfortunately, no validated markers exist to predict future infertility for couples initiating or delaying the process of reproduction. Despite limited supporting evidence, markers of ovarian aging are being measured at doctor's offices and in commercial home kits as a method of assessing women's fertility. Our long term goal is to examine the ability of markers of ovarian aging to predict infertility in the general population. The objective of this small, exploratory study is to determine the extent to which markers of ovarian aging associate with fecundability (probability of conception per cycle) in a reproductive age population of unknown fertility potential. Findings from this study will be used to select the number, timing, and choice of markers for predictive testing in a future, larger cohort. The proposed study will enroll 100 women from the community, who desire to conceive, and obtain baseline measures of ovarian aging: early follicular phase serum follicle stimulating hormone, inhibin B, and anti-mullerian hormone. Participants will be actively followed throughout their attempts to conceive over the following six months. During that time, women will collect urine during the early follicular phase of each cycle for FSH measurement, conduct up to two home pregnancy tests per cycle for standardized pregnancy determination, and complete a daily diary for up to three menstrual cycles for collection of detailed exposure data. These methods will allow us to address our primary research aims: (1) generate preliminary estimates of the association between fecundability and markers of ovarian aging and (2) determine the cycle-to-cycle variation in an individual's markers of ovarian aging. The primary tools for the proposed study including a web-based diary system, computer-assisted interviews, data management and quality control systems, and experienced staff are in place, assuring feasibility. A simple, validated measure of reproductive potential would be of significant benefit to women, who are considering initiating or delaying childbearing. Given that unproven home urinary kits are already being marketed, a prospective study to determine their ability to predict fecundability and fertility in the general population is essential. PUBLIC HEALTH RELEVANCE: Couples attempting to conceive have approximately a 1 in 7 chance of being infertile at one year, resulting in significant distress and anxiety. A simple, validated measure of reproductive potential would be of major benefit to women, who are considering initiating or delaying childbearing. Given that unproven home urinary "fertility test" kits are already being marketed, a prospective study to determine their ability to predict fecundability and fertility in the general population is imperative.