Project 1

项目1

基本信息

  • 批准号:
    8676251
  • 负责人:
  • 金额:
    $ 19.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-05-01 至 2019-04-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY / ABSTRACT - PROJECT 1 Presently, there can be considerable uncertainty in the clinical diagnosis of the common neurodegenerative pathological dementia syndromes [AD, LBD and FTD] antemortem because of clinical heterogeneity (wherein the dementia underlying pathology does not match the clinical syndrome), subtle symptoms early in the disease process, and frequent occurrence of mixed dementias. The central aim of this proposal is to develop a methodology that uses the wealth of clinical, imaging and pathology data collected in past and current ADRC funding cycles to improve the antemortem prediction of the dementia pathology and long-term clinical outcomes in new incoming patients. Our working hypothesis is that an individual subject's cognitive performance can be approximately modeled based on the subjects multi-modal imaging scans which are surrogates of pathology, cognitive reserve, MRI evidence of CVD and demographics. Based on this hypothesis, we plan to integrate clinical, pathology and imaging information on about 370+ demented patients with autopsy diagnosis and at least one imaging exam available before death from the past and current ADRC cycles and use this information for diagnosis and prognosis of new incoming patients. The overall methodology which we will create will operate as follows: 1) identify the patients ("matched subjects") in our database who match the new incoming patient based on the multi-modal images, cognitive reserve, vascular disease and demographics and 2) use the matched subjects to aid in the diagnosis and prognosis of the new patient.
项目摘要/摘要-项目1

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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PRASHANTHI VEMURI其他文献

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{{ truncateString('PRASHANTHI VEMURI', 18)}}的其他基金

Exceptional Aging: Identifying Modifiers of Alzheimer's Disease Trajectories
异常衰老:识别阿尔茨海默病轨迹的改变因素
  • 批准号:
    9361654
  • 财政年份:
    2017
  • 资助金额:
    $ 19.5万
  • 项目类别:
Investigating Resistance and Resilience Mechanisms in Alzheimer’s Disease
研究阿尔茨海默病的抵抗力和恢复力机制
  • 批准号:
    10605784
  • 财政年份:
    2017
  • 资助金额:
    $ 19.5万
  • 项目类别:
Development, Validation, and Application of an Imaging based CVD Scale
基于成像的 CVD 量表的开发、验证和应用
  • 批准号:
    9156582
  • 财政年份:
    2016
  • 资助金额:
    $ 19.5万
  • 项目类别:
Development, Validation, and Application of an Imaging based CVD Scale
基于成像的 CVD 量表的开发、验证和应用
  • 批准号:
    9335998
  • 财政年份:
    2016
  • 资助金额:
    $ 19.5万
  • 项目类别:
HOW DOES RESERVE MODIFY LINKS BETWEEN COGNITION & IMAGING INDICES OF AD PATHOLOGY
储备如何改变认知之间的联系
  • 批准号:
    8733238
  • 财政年份:
    2013
  • 资助金额:
    $ 19.5万
  • 项目类别:
HOW DOES RESERVE MODIFY LINKS BETWEEN COGNITION & IMAGING INDICES OF AD PATHOLOGY
储备如何改变认知之间的联系
  • 批准号:
    8880085
  • 财政年份:
    2013
  • 资助金额:
    $ 19.5万
  • 项目类别:
HOW DOES RESERVE MODIFY LINKS BETWEEN COGNITION & IMAGING INDICES OF AD PATHOLOGY
储备如何改变认知之间的联系
  • 批准号:
    8324513
  • 财政年份:
    2011
  • 资助金额:
    $ 19.5万
  • 项目类别:
HOW DOES RESERVE MODIFY LINKS BETWEEN COGNITION & IMAGING INDICES OF AD PATHOLOGY
储备如何改变认知之间的联系
  • 批准号:
    8189012
  • 财政年份:
    2011
  • 资助金额:
    $ 19.5万
  • 项目类别:

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