Project 1

项目总结/摘要-项目1 目前，在常见的神经退行性疾病的临床诊断中存在相当大的不确定性。 病理性痴呆综合征[AD、LBD和FTD]，由于临床异质性（其中 痴呆的潜在病理学与临床综合征不匹配）， 疾病过程，以及混合性痴呆的频繁发生。这项建议的主要目的是制定一项 使用过去和当前ADRC中收集的大量临床、影像学和病理学数据的方法 资助周期，以改善痴呆症病理学的生前预测和长期临床 新入院患者的结局。我们的工作假设是个体主体的认知 可以基于受试者的多模态成像扫描来近似地对性能进行建模， 病理学、认知储备、CVD的MRI证据和人口统计学的替代物。基于此 假设，我们计划整合约370+痴呆症患者的临床，病理和影像学信息 尸检诊断和死亡前至少一次影像学检查可从过去和当前ADRC获得 循环，并使用这些信息来诊断和预测新的患者。整个方法 我们将创建如下操作：1）在我们的数据库中识别患者（“匹配的受试者”）， 根据多模态图像、认知储备、血管疾病和 人口统计学和2）使用匹配的受试者来帮助新患者的诊断和预后。

PROJECT SUMMARY / ABSTRACT - PROJECT 1 Presently, there can be considerable uncertainty in the clinical diagnosis of the common neurodegenerative pathological dementia syndromes [AD, LBD and FTD] antemortem because of clinical heterogeneity (wherein the dementia underlying pathology does not match the clinical syndrome), subtle symptoms early in the disease process, and frequent occurrence of mixed dementias. The central aim of this proposal is to develop a methodology that uses the wealth of clinical, imaging and pathology data collected in past and current ADRC funding cycles to improve the antemortem prediction of the dementia pathology and long-term clinical outcomes in new incoming patients. Our working hypothesis is that an individual subject's cognitive performance can be approximately modeled based on the subjects multi-modal imaging scans which are surrogates of pathology, cognitive reserve, MRI evidence of CVD and demographics. Based on this hypothesis, we plan to integrate clinical, pathology and imaging information on about 370+ demented patients with autopsy diagnosis and at least one imaging exam available before death from the past and current ADRC cycles and use this information for diagnosis and prognosis of new incoming patients. The overall methodology which we will create will operate as follows: 1) identify the patients ("matched subjects") in our database who match the new incoming patient based on the multi-modal images, cognitive reserve, vascular disease and demographics and 2) use the matched subjects to aid in the diagnosis and prognosis of the new patient.