Investigation into the intervention of arterial thrombosis and atherosclerosis using shear sensitive nanoparticle drug delivery

使用剪切敏感纳米颗粒药物递送干预动脉血栓形成和动脉粥样硬化的研究

• 批准号: nhmrc : GNT1083138
• 负责人: A/Pr Andrew Murphy
• 金额: $ 44.71万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-intervention-arterial-drug-delivery/1345492
• 关键词: Investigation; into; intervention; arterial; thrombosis

In this project we aim to provide a targeted therapy that inhibits atherosclerosis, in-stent restenosis and thrombosis; pathologies characterized by high shear stress due to a reduction in the vessel lumen. We will apply microfluidic technology to characterize lipid nano-capsules that are tagged with antibodies against activated platelets or VCAM-1, loaded with anti-platelet or immune suppressive drugs and are prone to rupture specifically under high shear stress conditions.

在这个项目中，我们的目标是提供一种靶向治疗，抑制动脉粥样硬化，支架内再狭窄和血栓形成;病理特征是高剪切应力，由于在血管管腔减少。我们将应用微流体技术来表征脂质纳米胶囊，这些脂质纳米胶囊用抗活化血小板或VCAM-1的抗体标记，装载有抗血小板或免疫抑制药物，并且在高剪切应力条件下特别容易破裂。