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Targeting dysfunctional mitochondria in macrophages to inhibit atherosclerosis

Targeting dysfunctional mitochondria in macrophages to inhibit atherosclerosis
针对巨噬细胞中功能失调的线粒体来抑制动脉粥样硬化
批准号:
nhmrc : 1142938
负责人:
A/Pr Andrew Murphy
金额:
$68.28万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2021-12-31

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中文摘要
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英文摘要
The major contributing cells to heart disease are macrophages. These cells scavenge cholesterol, keeping the blood vessels clean and limiting heart disease. The macrophages must process and donate the scavenged cholesterol onto HDL-cholesterol that carries them back to the liver for removal. This process requires the powerhouse of the cell, the mitochondria to be functional. We have discovered that process fails and have novel drugs to re-instate this process of cholesterol removal.
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Targeting dysfunctional mitochondria in macrophages to inhibit atherosclerosis
  • 批准号:
    nhmrc : GNT1142938
  • 项目类别:
    Project Grants
  • 资助金额:
    $100.98万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Andrew Murphy
  • 依托单位:
NLRP1 and obesity
NLRP1 and obesity
  • 批准号:
    nhmrc : GNT1142354
  • 项目类别:
    International Collaborations
  • 资助金额:
    $34.34万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Andrew Murphy
  • 依托单位:
S100A8/A9 as a target in metabolic diseases to inhibit the acceleration of cardiovascular disease
  • 批准号:
    nhmrc : GNT1106154
  • 项目类别:
    Project Grants
  • 资助金额:
    $55.5万
  • 财政年份:
    2016
  • 负责人:
    A/Pr Andrew Murphy
  • 依托单位:
海外基金