Supraspinal Contributions to Locomotor Control and Recovery after Stroke

描述（由申请人提供）：神经成像技术的进步，如功能性磁共振成像（fMRI），使得检查中风后患者运动过程中的大脑功能成为可能。随着技术的进步和对脑卒中后脑功能的更好理解，脑成像可用于预测治疗效果和识别康复的生理标志。这些进展将特别有助于运动康复，因为行走能力受损是卒中后生活质量的主要障碍。然而，技术上的挑战使得在类似运动的运动中对大脑进行成像变得困难。这里提出的研究项目的目的是使用功能磁共振成像来了解大脑如何控制中风后患者下肢的运动。踏板将被用作运动模型。pi将检验以下假设：中风后运动能力受损与未受损一侧大脑皮层中与蹬车相关的大脑活动异常升高有关，而运动能力的改善与大脑活动的焦点转移到受损一侧大脑皮层的备用区域和小脑有关。这是一份指导研究科学家发展奖的申请，该奖项将允许申请人发展所需的研究技能，以追求独立的、富有成效的康复研究职业。申请人是一名具有康复研究博士和博士后培训的物理治疗师。她的长期目标是领导一个独立的、国家认可的实验室，研究神经损伤患者的脊柱上运动控制。这是运动控制中一个重要的新兴领域，候选人可以在她的职业生涯中做出有意义的贡献。候选人将利用她的发现来开发和测试增强中风后运动恢复的康复活动。该申请包括一个职业发展计划，以申请人在神经控制运动方面的现有技能为基础，并提供额外的脑功能成像、脊柱上运动控制、神经适应的生理基础、临床试验的设计和分析以及负责任的研究行为方面的培训。她选择了三位知名科学家（博士）作为导师。Brian Schmit， Kristina Ropella和Jules Dewald)在相关内容领域的专业知识和资助的研究项目。每个导师对自己的成功都有坚定的承诺。

DESCRIPTION (provided by applicant): Advances in neural imaging technologies, such as functional magnetic resonance imaging (fMRI), have made it possible to examine human brain function during movement in people post stroke. As technologies advance and a better understanding of post-stroke brain function emerges, brain imaging may be used to predict treatment effectiveness and to identify physiological markers of recovery. These advances will be particularly helpful for locomotor rehabilitation, because impaired walking ability is a major obstacle to quality of life post stroke. However, technical challenges have made it difficult to image the brain during locomotor-like movements. The purpose of the research project proposed here is to use fMRI to understand how the brain controls locomotor-like movements of the lower extremities in people post stroke. Pedaling will be used as a model of locomotion. The PIs will test the hypotheses that impaired locomotor ability post stroke is associated with abnormally elevated pedaling-related brain activity in the cerebral cortex on the undamaged side of the brain and that improved locomotor ability is associated with a shift in the focus of brain activity to spared cortical regions on the damaged side of the brain and to the cerebellum. This is an application for a Mentored Research Scientist Development Award that will allow the applicant to develop the research skills required to pursue an independent, productive career in rehabilitation research. The applicant is a physical therapist with doctoral and postdoctoral training in rehabilitation research. Her long term goal is to lead an independent, nationally recognized laboratory that examines supraspinal control of locomotion in people with neural injury. This is an important, emerging area in motor control to which the candidate can make meaningful contributions across her career trajectory. The candidate will use her discoveries to develop and test rehabilitation activities that enhance locomotor recovery after stroke. This application includes a career development plan that builds on the applicant's existing skills in neural control of movement and provides additional training in functional brain imaging, supraspinal control of locomotion, the physiological basis of neural adaptation, design and analysis of clinical trials, and the responsible conduct of research. She has selected as mentors three established scientists (Drs. Brian Schmit, Kristina Ropella, and Jules Dewald) with expertise in relevant content areas and funded research programs. Each mentor has a strong commitment to her success. PUBLIC HEALTH RELEVANCE: Many stroke survivors fail to regain walking ability which leads to poor quality of life. A better understanding of how the brain controls locomotion many lead to more effective treatments. The results of this study will provide insight into how the post-stroke brain controls locomotion and may lead to novel treatments for improving locomotion after stroke.