Supraspinal Contributions to Locomotor Control and Recovery after Stroke

脊柱上对中风后运动控制和恢复的贡献

• 批准号: 8431356
• 负责人: SHEILA M SCHINDLER-IVENS
• 金额: $ 11.56万
• 依托单位: MARQUETTE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8431356
• 关键词: Accounting; Acute; Age; Area; Beds; Bilateral; Brain; Brain imaging; Brain region; Cerebellum; Cerebral cortex; Cerebral hemisphere; Characteristics; Chronic Phase; Clinical; Clinical Trials; Detection; Development Plans; Event; Functional Magnetic Resonance Imaging; Funding; Goals; Hand; Human; Imaging technology; Impairment; Laboratories; Lead; Leg; Locomotion; Locomotor Recovery; Lower Extremity; Measures; Mentored Research Scientist Development Award; Mentors; Methods; Modeling; Morphologic artifacts; Motion; Motor; Movement; Participant; Phase; Physiological; Procedures; Process; Quality of life; Recovery; Rehabilitation Research; Rehabilitation therapy; Research; Research Project Grants; Scientist; Side; Signal Transduction; Stroke; Survivors; Techniques; Technology; Testing; Time; Training; Treatment Effectiveness; Upper Extremity; Walking; Work; acute stroke; base; blood oxygenation level dependent response; career; career development; chronic stroke; computerized data processing; design; effective therapy; hemiparesis; hemisphere damage; improved; insight; mind control; motor control; nerve injury; neuroadaptation; neuroregulation; novel; post stroke; post-doctoral training; programs; public health relevance; relating to nervous system; response; responsible research conduct; skills; somatosensory; success; tool

DESCRIPTION (provided by applicant): Advances in neural imaging technologies, such as functional magnetic resonance imaging (fMRI), have made it possible to examine human brain function during movement in people post stroke. As technologies advance and a better understanding of post-stroke brain function emerges, brain imaging may be used to predict treatment effectiveness and to identify physiological markers of recovery. These advances will be particularly helpful for locomotor rehabilitation, because impaired walking ability is a major obstacle to quality of life post stroke. However, technical challenges have made it difficult to image the brain during locomotor-like movements. The purpose of the research project proposed here is to use fMRI to understand how the brain controls locomotor-like movements of the lower extremities in people post stroke. Pedaling will be used as a model of locomotion. The PIs will test the hypotheses that impaired locomotor ability post stroke is associated with abnormally elevated pedaling-related brain activity in the cerebral cortex on the undamaged side of the brain and that improved locomotor ability is associated with a shift in the focus of brain activity to spared cortical regions on the damaged side of the brain and to the cerebellum. This is an application for a Mentored Research Scientist Development Award that will allow the applicant to develop the research skills required to pursue an independent, productive career in rehabilitation research. The applicant is a physical therapist with doctoral and postdoctoral training in rehabilitation research. Her long term goal is to lead an independent, nationally recognized laboratory that examines supraspinal control of locomotion in people with neural injury. This is an important, emerging area in motor control to which the candidate can make meaningful contributions across her career trajectory. The candidate will use her discoveries to develop and test rehabilitation activities that enhance locomotor recovery after stroke. This application includes a career development plan that builds on the applicant's existing skills in neural control of movement and provides additional training in functional brain imaging, supraspinal control of locomotion, the physiological basis of neural adaptation, design and analysis of clinical trials, and the responsible conduct of research. She has selected as mentors three established scientists (Drs. Brian Schmit, Kristina Ropella, and Jules Dewald) with expertise in relevant content areas and funded research programs. Each mentor has a strong commitment to her success.

描述（由申请人提供）：神经成像技术的进步，例如功能性磁共振成像（fMRI），已使中风后人运动期间在运动中检查人脑功能成为可能。随着技术的发展并更好地了解势后脑功能，可以使用大脑成像来预测治疗效果并鉴定恢复的生理标志物。这些进步对运动康复特别有用，因为步行能力受损是中风后生活质量的主要障碍。但是，技术挑战使得在类似运动的运动过程中很难成像大脑。这里提出的研究项目的目的是使用fMRI了解中风后人中下肢的运动状运动如何控制运动。踏板将用作运动模型。 PI将检验中风后运动能力受损的假设与脑部未损坏的大脑一侧的大脑皮层中与脚踏板相关的大脑活动异常升高，并且改善的运动能力与脑活动的脑活动的焦点转移有关，与脑受损的脑部和脑损坏的脑受损的脑活动区域有关。这是一个指导的研究科学家发展奖的申请，该奖项将使申请人能够发展从事康复研究中独立，富有成效的职业所需的研究技能。申请人是一名物理治疗师，接受了康复研究的博士和博士后培训。她的长期目标是领导一个独立的，全国认可的实验室，该实验室检查神经损伤患者对运动的上跨度控制。这是运动控制中的一个重要的新兴领域，候选人可以在其职业轨迹中做出有意义的贡献。候选人将使用她的发现开发和测试康复活动，从而增强中风后的运动恢复。该申请包括一项职业发展计划，该计划基于申请人在运动神经控制方面的现有技能，并提供了功能性脑成像，运动上的跨脊髓控制，神经适应性的生理基础，临床试验的设计和分析以及负责任的研究。她在相关内容领域和资助的研究计划中选择了三位成熟的科学家（Brian Schmit，Kristina Ropella博士，Kristina Ropella和Jules Dewald）。每个导师对她的成功都有坚定的承诺。