ALTERED MUSCLE ACTIVITY DURING LOCOMOTION POST-STROKE

中风后运动过程中肌肉活动的改变

• 批准号: 6747622
• 负责人: SHEILA M SCHINDLER-IVENS
• 金额: $ 4.89万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6747622
• 关键词: clinical research; gait; hemiplegia; human subject; muscle function; neural information processing; neuromuscular transmission; patient oriented research; physical therapy; postdoctoral investigator; rehabilitation; stretch reflex; stroke therapy

DESCRIPTION (provided by applicant): A major obstacle to quality of life for stroke survivors is impaired walking ability, and restoration of locomotion is an important goal. The objective of this research is to identify mechanisms contributing to impaired walking ability post-stroke. Locomotion is normally characterized by critically-timed patterns of muscle activity in the legs. However, in persons with post-stroke hemiparesis, muscle activity is abnormally timed, which contributes to slow and unsafe locomotion. The causes of abnormal locomotor muscle timing are poorly understood; however, a dominant theory is that abnormal muscle timing is due to hyperactive stretch reflexes. Another possibility is that locomotor muscle activation patterns are fundamentally reorganized. This study aims to identify the contributions of elevated stretch reflexes and reorganization of the locomotor pattern to abnormal muscle timing post-stroke. Subjects with and without post-stroke hemiparesis will participate. Using a pedaling task, the direction of locomotion will be manipulated, and cutaneous reflexes will be elicited in leg muscles. Muscle activity and cutaneous reflex amplitude will be quantified during pedaling. It is hypothesized that, if abnormal locomotor muscle timing arises from elevated stretch reflexes, abnormal muscle activity will be present during muscle lengthening, regardless of pedaling direction. If the locomotor pattern is reorganized post-stroke, direction-dependent changes in muscle timing that are related to the sequence of the biomechanical components of pedaling will be observed, and cutaneous reflex modulation will be reorganized.

描述（由申请人提供）：卒中幸存者生活质量的主要障碍是行走能力受损，恢复运动能力是一个重要目标。本研究的目的是确定脑卒中后步行能力受损的机制。运动通常以腿部肌肉活动的关键定时模式为特征。然而，在中风后轻偏瘫患者中，肌肉活动的时间异常，这导致缓慢和不安全的运动。运动肌肉定时异常的原因知之甚少;然而，一个占主导地位的理论是，异常的肌肉定时是由于过度活跃的拉伸反射。另一种可能性是运动肌肉激活模式从根本上重组。本研究的目的是确定的贡献，提高牵张反射和重组的运动模式，异常的肌肉时序中风后。有和没有卒中后轻偏瘫的受试者将参与研究。使用踩踏板任务，运动的方向将被操纵，并且腿部肌肉中的皮肤反射将被引发。在踩踏过程中，将量化肌肉活动和皮肤反射幅度。据推测，如果异常的运动肌肉定时引起的拉伸反射升高，异常的肌肉活动将在肌肉延长，无论踩踏方向。如果运动模式在中风后重组，将观察到与踩踏生物力学组件的顺序相关的肌肉计时的方向依赖性变化，并且皮肤反射调制将重组。

项目成果

Lower extremity passive range of motion in community-ambulating stroke survivors.

社区行走中风幸存者下肢被动活动范围。

• DOI: 10.1097/npt.0b013e31816594ea
• 发表时间: 2008
• 期刊: Journal of neurologic physical therapy : JNPT
• 作者: Schindler-Ivens,Sheila;Desimone,Davalyn;Grubich,Sarah;Kelley,Carolyn;Sanghvi,Namita;Brown,DavidA
• 通讯作者: Brown,DavidA