Defining the Immunomodulatory Niche of Schistosoma haematobium IPSE
埃及血吸虫 IPSE 免疫调节生态位的定义
基本信息
- 批准号:9107658
- 负责人:
- 金额:$ 47.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-01 至 2017-08-31
- 项目状态:已结题
- 来源:
- 关键词:AchievementAddressAdhesionsAdoptedAdultAffinityAfricanAllelesAntibodiesBindingBiochemicalBiological AssayBladderCell LineCell NucleusCellsChemotaxisCloningClustered Regularly Interspaced Short Palindromic RepeatsComplementary DNAConsensus SequenceCysteineDepositionElectrical ResistanceEnvironmentEnzyme-Linked Immunosorbent AssayEpithelialEpitheliumExtracellular MatrixFibroblastsFibrosisFluorescence MicroscopyGene ExpressionGenesGeneticGenetic TranscriptionGenitourinary systemGenomeGranulomaHealthHelminthsHomologous GeneHumanIgEImmuneImmune responseImmunityImmunofluorescence MicroscopyImmunoglobulin GImmunoglobulinsIn VitroIndividualInfectionInfiltrationInflammatoryInflammatory ResponseInstitutionInterleukin-4IntestinesKineticsKnowledgeLiverLiver FibrosisLocationMalariaMalignant neoplasm of urinary bladderMeasurementMeasuresMethodsModelingMoldsMusNuclearNuclear ProteinNuclear TranslocationParasitesPathologyPathway interactionsPeptide Signal SequencesPopulationPropertyProtein ArrayProteinsPublishingRNA InterferenceRecombinantsResearchResearch PersonnelReverse Transcriptase Polymerase Chain ReactionRiskRoleSchistosomaSchistosoma haematobiumSchistosoma hematobium infectionSchistosoma mansoniSchistosoma mansonii infectionSchistosomiasisScientistSequence HomologsSisterSpecificitySurface Plasmon ResonanceTestingTherapeuticTight JunctionsTimeTissue SurvivalTransgenic OrganismsUrothelial CellUrothelial Hyperplasiabasechemokinecytokinedisulfide bondeconomic impacteggelectric impedancegenetic manipulationgenome editingglycosylationhuman morbidityhuman mortalityimmune clearanceimmunoregulationin vivomacrophagemouse modelneglected tropical diseasesnovelnovel therapeuticspreventresearch studysocioeconomicssuccesstoolvector
项目摘要
DESCRIPTION (provided by applicant): Approximately 120 million individuals are infected with Schistosoma haematobium in sub-Saharan African alone. S. haematobium adult worms, the causative agent of urogenital schistosomiasis, lay eggs throughout the urogenital tract. These eggs induce a pronounced inflammatory response responsible for the human morbidity and mortality associated with infection. To date very little is known about how S. haematobium is able to induce such a robust immune response while evading immune clearance and immunity in many individuals. This lack of knowledge is due to the historical lack of both a model for S. haematobium egg- associated pathology, and genetic tools for manipulation of the S. haematobium parasite. Building on recent advances in the S. haematobium field, this collaborative proposal employs the first published mouse model of S. haematobium induced bladder pathology (generated by the PI), and the first successful approaches for genetic manipulation of S. haemtobium (pioneered by the co-investigators). The experiments proposed will explore the functions of the S. haematobium homolog of the parasite egg- secreted immunomodulatory protein IPSE. IPSE was originally described in S. mansoni, the sister species of schistosome responsible for hepatoenteric schistosomiasis. IPSE is the most abundant S. mansoni egg secreted protein, and has numerous published biochemical functions, many of which were first described by a co-investigator on this proposal. Our collaborative team across four institutions will first define the biochemical functions of the S. haematobium IPSE homologue. We will then generate genetically modified S. haematobium strains with deficient IPSE gene expression to determine the effects of IPSE in vivo. Achievement of the aims of this proposal would represent key milestones for S. haematobium research, including, to our knowledge, the first studies on S. haematobium-derived immunomodulatory proteins and the first use of transgenic S. haematobium strains to determine the function of an S. haematobium protein in vivo.
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Defining the Pathways of Urogenital Schistosomiasis-Associated Urothelial Carcinogenesis through Transgenic and Bladder Wall Egg Injection Models.
- DOI:10.1007/978-1-4939-7234-0_6
- 发表时间:2018
- 期刊:
- 影响因子:0
- 作者:E. Mbanefo;M. Hsieh
- 通讯作者:E. Mbanefo;M. Hsieh
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Michael Harrison Hsieh其他文献
Michael Harrison Hsieh的其他文献
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{{ truncateString('Michael Harrison Hsieh', 18)}}的其他基金
Next Generation Robotic System for Supervised-Autonomous Bowel Anastomosis
用于监督自主肠吻合术的下一代机器人系统
- 批准号:
10910494 - 财政年份:2023
- 资助金额:
$ 47.12万 - 项目类别:
Developing a Next Generation Mouse Model of Urogenital Schistosomiasis Through Ultrasound-Guided Percutaneous Bladder Wall Injection of Schistosoma haematobium Eggs
通过超声引导经皮膀胱壁注射埃及血吸虫卵开发下一代泌尿生殖血吸虫病小鼠模型
- 批准号:
10041747 - 财政年份:2020
- 资助金额:
$ 47.12万 - 项目类别:
Developing a Next Generation Mouse Model of Urogenital Schistosomiasis Through Ultrasound-Guided Percutaneous Bladder Wall Injection of Schistosoma haematobium Eggs
通过超声引导经皮膀胱壁注射埃及血吸虫卵开发下一代泌尿生殖血吸虫病小鼠模型
- 批准号:
10171777 - 财政年份:2020
- 资助金额:
$ 47.12万 - 项目类别:
Therapeutic Exploitation of IPSE, a Urogenital Parasite-Derived Host Modulatory Protein, for Bladder Hypersensitivity Syndromes
IPSE(一种泌尿生殖寄生虫衍生的宿主调节蛋白)对膀胱过敏综合征的治疗利用
- 批准号:
9288039 - 财政年份:2017
- 资助金额:
$ 47.12万 - 项目类别:
Therapeutic Exploitation of IPSE, a Urogenital Parasite-Derived Host Modulatory Protein, for Bladder Hypersensitivity Syndromes
IPSE(一种泌尿生殖寄生虫衍生的宿主调节蛋白)对膀胱过敏综合征的治疗利用
- 批准号:
9918915 - 财政年份:2017
- 资助金额:
$ 47.12万 - 项目类别:
Therapeutic Exploitation of IPSE, a Urogenital Parasite-Derived Host Modulatory Protein, for Bladder Hypersensitivity Syndromes
IPSE(一种泌尿生殖寄生虫衍生的宿主调节蛋白)对膀胱过敏综合征的治疗利用
- 批准号:
10124792 - 财政年份:2017
- 资助金额:
$ 47.12万 - 项目类别:
Estrogenic Modulation of Genitourinary Epithelial-Probiotic Cross-Talk
泌尿生殖上皮-益生菌相互作用的雌激素调节
- 批准号:
8898940 - 财政年份:2010
- 资助金额:
$ 47.12万 - 项目类别:
Estrogenic Modulation of Genitourinary Epithelial-Probiotic Cross-Talk
泌尿生殖上皮-益生菌相互作用的雌激素调节
- 批准号:
8075642 - 财政年份:2010
- 资助金额:
$ 47.12万 - 项目类别:
Estrogenic Modulation of Genitourinary Epithelial-Probiotic Cross-Talk
泌尿生殖上皮-益生菌相互作用的雌激素调节
- 批准号:
8469028 - 财政年份:2010
- 资助金额:
$ 47.12万 - 项目类别:
Estrogenic Modulation of Genitourinary Epithelial-Probiotic Cross-Talk
泌尿生殖上皮-益生菌相互作用的雌激素调节
- 批准号:
8272675 - 财政年份:2010
- 资助金额:
$ 47.12万 - 项目类别:
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