Corticospinal Control of Sensorimotor Synergies in Health and Disease.

健康和疾病中感觉运动协同作用的皮质脊髓控制。

• 批准号: 8923323
• 负责人: Sergiy Yakovenko
• 金额: $ 27.67万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8923323
• 关键词: Accounting; Address; Animals; Behavior; Bilateral; Brain Injuries; Bypass; Cardiovascular system; Cervical; Communities; Complex; Data; Development; Devices; Disease; Electrodes; Forelimb; Fostering; Funding; Gait; Generations; Goals; Guidelines; Health; Human; Implant; Injury; Interneurons; Intervention; Intramuscular; Laboratories; Locomotion; Measures; Mentors; Mentorship; Microelectrodes; Middle Cerebral Artery Occlusion; Motor; Motor Cortex; Movement; Muscle; Muscle Weakness; Neuraxis; Neurons; Neurosciences; Pathway interactions; Patients; Pattern; Peripheral; Plastics; Positioning Attribute; Process; Program Research Project Grants; Rattus; Recovery; Recovery of Function; Recruitment Activity; Relative (related person); Research; Research Activity; Research Personnel; Rodent; Rodent Model; Services; Signal Transduction; Site; Spinal; Spinal Cord; Stroke; Surface; System; Techniques; Technology; Testing; Time; Walking; West Virginia; Work; career development; cortex mapping; dexterity; flexibility; functional restoration; implantable device; improved; injured; interdisciplinary approach; microstimulation; motor control; motor disorder; nerve injury; neuromechanism; neuroprosthesis; neurotransmission; novel; rehabilitation strategy; relating to nervous system; sensory feedback; spatiotemporal; spinal pathway; success; theories

This proposal addresses the fundamental question of how to overcome disruption of muscle activation and coordination after neural injury such as stroke. Our goal is to understand interaction dynamics among all hierarchical levels. Our objectives are to determine signal generation and interactions between primary motor cortex (Ml) and spinal cord (SC) nehworks for the control of gross and fine movements and to chart the functional reorganization of Ml after stroke. Our central hypothesis is that the relative contribution and the hierarchy of interactions between Ml and SC mechanisms for the control of functional muscle groups or motor synergies will depend on the required dexterity of movement. For this purpose, data will be obtained from rats performing tasks that range from basic, stereotypical behaviors such as locomotion to more complex, dexterous behaviors such as walking on horizontal ladders with asymmetric rung position and reaching movements. In Aim 1, we will probe the neural system at the cortical level with microelectrode arrays implanted bilaterally in Ml, at the spinal level with epidural electrode array over cervical enlargement, and in the peripheral system with intramuscular electrodes. The activity of single neurons and local field potential will be examined in the context of their contribution to the control of motor synergies. The organization between Ml, spinal pathways and sensory feedback mechanisms will be examined with paired stimulation of cortical and peripheral pathways. In Aim 2, we will study how these corticospinal mechanisms reorganize and recover after a focal cortical damage by the reversible occlusion of middle cerebral artery. The proposed studies will reveal fundamental neural mechanisms of interactions between different levels of control hierarchy in animals before and after transient stroke. This ground work will help to develop strategies to restore functionality that improves symmetric gait and dexterity beyond intrinsic recovery capabilities of the motor control system. Results from these studies will be used to enhance neuroprosthetic technologies that restore function to patients who suffer motor dysfunction.

该建议解决了如何克服肌肉激活中断的基本问题， 协调神经损伤后，如中风。我们的目标是了解所有人之间的互动动态 等级层次。我们的目标是确定信号的产生和初级之间的相互作用 运动皮层（Ml）和脊髓（SC）网络，用于控制粗略和精细运动， 脑卒中后Ml的功能重组。我们的中心假设是，相对贡献和 - 用于控制功能性肌群的Ml和SC机制之间的相互作用的层级，或 运动协同作用将取决于所需的运动灵活性。 为此，将从执行任务的大鼠中获得数据，这些任务的范围从基本的，刻板的， 从运动等行为到更复杂、灵巧的行为，如在水平梯子上行走 具有不对称的梯级位置和伸展运动。在目标1中，我们将在 皮质水平，双侧植入微电极阵列，脊髓水平，硬膜外电极 在颈部扩大的阵列，并在外周系统与肌内电极。的活性 单个神经元和局部场电位将在它们对控制的贡献的背景下进行检查 运动协同Ml、脊髓通路和感觉反馈机制之间的组织将是 通过皮层和外周通路的配对刺激进行检查。在目标2中，我们将研究这些 皮质脊髓机制重组和恢复后，局灶性皮质损伤的可逆性闭塞， 大脑中动脉 这些研究将揭示不同水平的神经元之间相互作用的基本神经机制。 短暂性中风前后动物的控制等级。这项基础工作将有助于发展 恢复功能的策略，可改善对称步态和灵活性，超越内在恢复 电机控制系统的性能。这些研究的结果将用于增强神经假体 为运动功能障碍患者恢复功能的技术。