Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer Research

癌症研究中大量遗传和基因组数据分析的统计方法

• 批准号: 8955524
• 负责人: XIHONG LIN
• 金额: $ 96.35万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-05 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8955524
• 关键词: Advanced Malignant Neoplasm; Biotechnology; Cancer Burden; Cancer Etiology; Cancer Prevention Intervention; Cancer Prognosis; Clinical; Clinical Data; Clinical Research; Cohort Studies; Communities; Complex; Computerized Medical Record; Computing Methodologies; Data; Data Sources; Databases; Development; Environment; Epidemiologic Studies; Epidemiologist; Epidemiology; Explosion; Generations; Genetic; Genome; Genomics; Goals; Health; Healthcare; Information Technology; Knowledge; Learning Module; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of nasopharynx; Medical; Medicare claim; Medicine; Methods; Patient Care; Play; Population; Public Health Informatics; Research; Research Personnel; Risk; Role; Science; Scientist; Statistical Methods; Technology; Training; Translating; administrative database; anticancer research; cancer epidemiology; cancer genetics; cancer genomics; cancer prevention; cancer therapy; gene environment interaction; genetic analysis; genome sequencing; improved; innovation; insight; malignant breast neoplasm; outcome forecast; precision medicine; public health relevance; user friendly software

 DESCRIPTION (provided by applicant): With the advances of technologies, cancer research enterprise is rapidly becoming data-intensive and data- driven. One example is the explosion of biotechnologies and the generation of massive genetic and genomic data, such as whole genome sequencing data. Another example is health informatics, which allows rapid avail- ability of large administrative health care databases, such as electronic medical records and Medicare claim data. Cancer data science has emerged to be increasingly important in cancer research. Indeed, massive data provide unprecedented opportunities for new discovery in cancer. This project aims at development and application of statistical and computational methods for analysis of massive and complex genetic and genomic data, together with epidemiological and clinical data, in population and medical science of cancer research. Our ultimate goal is to use rich data sources to understand cancer etiology, risk, and prognosis, and discover new effective strategies for cancer prevention, intervention and treatment. It has become increasingly evident that limited methods suitable for analyzing massive data have emerged as a bottleneck to effectively translate rich information into meaningful knowledge. There is a pressing need to develop statistical and computational methods for massive cancer data to bridge the technology and information transfer gap, and accelerate innovations in cancer prevention and treatment. This Project aims at narrowing this gap. Specifically, to advance genetic and genomic cancer epidemiology, we will develop statistical and computational methods for (a) analysis of whole genome sequencing association studies; (b) integrative analysis of genetic, genomic, and environment data; (c) study of gene-environment interactions; (d) risk prediction using whole genome genetic and genomic data and environmental data. To advance cancer genomic medicine, we will develop statistical and computational methods for integrative analysis of genetic, genomic and clinical data to understand cancer prognosis and advance precision medicine using (a) data from genetic epidemiological cohort studies; (b) combining data from genetic epidemiological cohort studies with administrative databases such as electronic medical records and Medicare claim data. We have assembled a strong collaborative interdisciplinary team of researchers involving biostatisticians, computational biologists, health informaticians, genetic epidemiologists and clinical scientists. We will apply te proposed methods to lung, breast and nasopharynx cancer genetic epidemiological and clinical studies. We will develop open access user friendly software to be distributed to the research community, and open online educational modules for training cancer researchers in using the methods developed in this Project.