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Exploring the Neural Correlates of Object Percepts in the Head-Restrained Mouse

探索头部约束小鼠物体感知的神经相关性

基本信息

批准号：
8970039
负责人：
ARIEL AGMON
金额：
$ 7.45万
依托单位：
WEST VIRGINIA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8970039
关键词：
3-Dimensional Address Agnosia Algorithms Animals Anterior Apple Area Behavioral Brain Brain Injuries Brain region Calcium Cerebral cortex Cone Conscious Cues Decision Making Environment Functional Magnetic Resonance Imaging Future Genetic Goals Head Human Image Imaging Device Interneurons Learning Left Light Location Methodology Methods Mind Monkeys Motor Motor Cortex Mus Nature Neurons Neurosciences Parietal Lobe Pattern Perception Performance Primates Procedures Process Psyche structure Research Personnel Resolution Rodent Role Sampling Sensory Sensory Process Short-Term Memory Signal Transduction Somatosensory Cortex Symptoms System Tactile Techniques Testing Thinking Trackball Device Component Training Ursidae Family Vibrissae Work base cingulate cortex cognitive ability cognitive neuroscience cognitive process cranium extracellular follow-up memory process molecular imaging motor control neural correlate nonhuman primate object perception object recognition optogenetics public health relevance relating to nervous system research study response spatiotemporal

项目摘要

DESCRIPTION (provided by applicant): The long-term objective of this two-year project is to develop the methodology for exploring whisker-dependent object recognition and perceptual decision in head- restrained mice. Object recognition and perceptual decision are higher-order cognitive abilities that have traditionally been studied in humans (with functional MRI) and in head- restrained monkeys (with extracellular recordings). Our goal is to develop experimental procedures to address similar questions in mice, for which there are powerful genetic, molecular and imaging tools not available in primates. We will expand upon the Go- NoGo task developed in the Svoboda lab for testing object localization in head- restrained mice, and develop a single-interval forced-choice task in which the mouse will use its whiskers to discriminate between two canonical objects (e.g. a cube and a sphere), and signal its decision by turning a trackball to the left or to the right. We will then use the clear-skull technique developed by the Svoboda lab to inactivate by light specific cortical areas, and thereby identify the areas required for performing the task. This experimental system will enable follow-up studies which will bring to bear state-of- the-art methods for electrophysiological recordings, calcium imaging and optogenetic stimulation on higher cognitive processes such as object recognition and perceptual decision, as well as the underlying learning and memory processes.