Electrophysiology

电生理学

基本信息

批准号：
8795708
负责人：
Carolyn J Brown
金额：
$ 33.09万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至 2016-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8795708
关键词：
Acoustic Nerve Acoustic Stimulation Acoustics Action Potentials Address Adoption Adult Affect Age Auditory Auditory Evoked Potentials Auditory system Behavioral Brain Child Childhood Clinical Clinical Research Cochlear Implants Complex Data Data Set Development Ear Effectiveness Electric Stimulation Electrophysiology (science)Evoked Potentials Exhibits Frequencies Goals Grant Growth Hearing Hearing Aids Hybrids Individual Iowa Lead Maps Measures Methods Modeling Morphology Music Neuraxis Noise Outcome Measure Participant Perception Performance Peripheral Physiological Physiological Processes Plastics Pliability Population Procedures Process Relative (related person)Residual state Series Signal Transduction Speech Speech Perception Stimulus Structure Study Subject TNFRSF5 gene Technology Testing Time Training Training Programs auditory pathway base clinical decision-making clinical practice comparison group design implantation improved indexing patient population pediatric patients programs relating to nervous system research study response signal processing success

项目摘要

Project 4: An overall goal of this P50 is to evaluate the possible advantages that cochlear implants (Cl) designed to preserve acoustic hearing (Hybrid Cl) may have for potential Cl recipients. The other four projects in this grant use perceptual measures to characterize performance by different groups of study participants (adult vs children, hybrid vs bimodal vs standard Cl users). In this section the focus is on developing methods of predicting performance with a Cl that do not rely on behavioral participation by the user. The goal of the first .set of experiments is to develop and validate an evoked potential (EP) test battery that includes both peripheral (compound action potential) and central (cortical change response) measures of neural response and can be used to predict performance with a Cl. Peripheral EP measures (e.g. ECAP growth and/or channel interaction) will be used to characterize limitations in the information transfer imposed by the speech processor and the auditory nerve. Cortical EP measures, particularly those evoked in response to a change in some aspect of a complex signal (music, speech and/or ripple noise), will provide an index to the way complex signals are processed in the central auditory pathways. Both measures will be compared with performance data and a statistical path analysis model will be used to evaluate the relative contributions of the different levels of physiological processing to overall perception. This approach will be used to evaluate normal hearing and bimodal listeners as well as Hybrid and standard Cl users. These data address questions of how acoustic and electric stimulation is integrated and how EP measures can be used in clinical settings with pediatric populations. A second set of experiments uses within-subject comparisons to evaluate the effects of training in both adults and children. The studies proposed focus on determining whether changes in a cortical EP, assessed using speech and/or musical stimuli before and immediately following participation in a short-term training program, can accurately predict benefit from participation in a longer term training program.

项目4：该P50的总体目标是评估旨在保存声学听力（Hybrid CL）的人工耳蜗（CL）可能具有潜在CL受体的可能优势。该赠款中的其他四个项目采用感知措施来表征不同研究参与者组的表现（成人与儿童，混合动力与双峰与标准CL用户）。在本节中，重点是开发不依赖用户行为参与的CL预测性能的方法。实验的第一个目标的目的是开发和验证诱发电位（EP）测试电池，其中包括外围（复合动作电位）和中央（皮质变化响应）神经反应的测量，并可以用CL来预测性能。外围EP度量（例如ECAP生长和/或通道相互作用）将用于表征语音处理器和听觉神经所施加的信息传输中的局限性。皮质EP测量，特别是那些响应复杂信号（音乐，语音和/或波纹噪声）的变化而引起的，将为中央听觉途径处理复杂信号的方式提供索引。这两种措施都将与绩效数据进行比较，并将使用统计路径分析模型来评估不同生理处理水平对整体感知的相对贡献。这种方法将用于评估正常的听力和双峰听众，以及混合动力和标准CL用户。这些数据解决了如何整合声学和电刺激以及如何在患有儿科种群的临床环境中使用EP措施。第二组实验使用受试者内比较来评估成人和儿童训练的影响。这些研究提出的重点是确定参加短期培训计划之前和立即使用语音和/或音乐刺激评估的皮质EP中的变化是否可以准确地预测参与长期培训计划的好处。