The Role of GM-CSF in the Pathogenesis of Multiple Sclerosis

GM-CSF 在多发性硬化症发病机制中的作用

基本信息

  • 批准号:
    8767198
  • 负责人:
  • 金额:
    $ 33.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-08-15 至 2019-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Th17 cells are important in the pathogenesis of EAE and it is hypothesized that they may play a similar role in MS. We have shown that GM-CSF plays an essential role in the encephalitogenicity of Th17 cells in EAE. The role of GM-CSF in the pathogenesis of MS has not been well studied, and the factors that can modulate this cytokine in health and disease are not known. Our preliminary data show that more T cells of MS patients produce GM-CSF than those of healthy individuals, and that IFN-b treatment reduces this production. Based on its role in EAE and our findings, we hypothesize that GM-CSF plays an important role in MS pathogenesis and is suppressed by treatment with IFN-b. To test this hypothesis we propose the following specific aims: Aim 1: To characterize GM-CSF production by T cells in the periphery and in MS lesions. The relevant cellular source of GM-CSF in EAE is myelin-specific T cells. It is likely that in MS myelin-specific T cells are also the principal souce of GM-CSF, but no study thus far has characterized its production by T cells in MS patients. Our preliminary data show that the majority of CD4+ and CD8+ T cells in acute MS brain lesions express GM-CSF. Others have shown that GM-CSF is increased in CSF of MS patients during relapse. These data support the hypothesis that GM-CSF plays a pathogenic role in MS. We will test the hypothesis that GM- CSF production by T cells is increased in MS. Aim 2: To investigate the effects of GM-CSF on microglial activation and their neurotoxicity. Our preliminary findings show that activated microglia in MS lesions express high levels of GM-CSF receptor, which, together with the production of GM-CSF by T cells, provides the basis for our hypothesis that GM-CSF mediates activation of microglia and promotes their neurotoxicity. Aim 3: To examine the effect of IFN-b on GM-CSF production in MS. IFN-b is a widely used treatment for MS, but its mechanism of disease modulation remains incompletely understood. The effect of IFN-b on GM-CSF production is unknown. Our preliminary findings show that IFN- b significantly reduces GM-CSF production by T cells, providing the basis for our hypothesis that IFN-b suppresses GM-CSF production by T cells in MS. This suppression may prove to be a biomarker for predicting the effectiveness of IFN-b therapy in individual MS patients.
描述(由申请人提供):多发性硬化症(MS)是一种中枢神经系统(CNS)自身免疫性疾病。Th17细胞在EAE的发病机制中起重要作用,据推测它们可能在ms中起类似的作用。我们已经证明GM-CSF在EAE中Th17细胞的脑致生作用中起重要作用。GM-CSF在MS发病中的作用尚未得到很好的研究,在健康和疾病中调节该细胞因子的因素尚不清楚。我们的初步数据显示,MS患者产生GM-CSF的T细胞比健康个体多,而IFN-b治疗减少了这种产生。基于GM-CSF在EAE中的作用和我们的研究结果,我们假设GM-CSF在MS发病机制中起重要作用,并被IFN-b治疗抑制。为了验证这一假设,我们提出以下具体目标:目的1:表征外周和MS病变中T细胞产生GM-CSF的特征。EAE中GM-CSF的相关细胞来源是髓磷脂特异性T细胞。在多发性硬化症中,髓磷脂特异性T细胞可能也是GM-CSF的主要来源,但迄今为止还没有研究表明多发性硬化症患者的T细胞产生GM-CSF。我们的初步数据显示,急性MS脑病变中大部分CD4+和CD8+ T细胞表达GM-CSF。其他研究显示多发性硬化症患者复发时脑脊液中GM-CSF升高。这些数据支持GM-CSF在ms中起致病作用的假设。我们将验证T细胞产生GM-CSF在ms中增加的假设。目的2:研究GM-CSF对小胶质细胞激活及其神经毒性的影响。我们的初步研究结果表明,MS病变中活化的小胶质细胞表达高水平的GM-CSF受体,这与T细胞产生GM-CSF一起,为我们的假设提供了GM-CSF介导小胶质细胞活化并促进其神经毒性的基础。目的3:研究IFN-b对MS中GM-CSF产生的影响IFN-b是一种广泛用于MS的治疗方法,但其疾病调节机制仍不完全清楚。IFN-b对GM-CSF产生的影响尚不清楚。我们的初步研究结果显示,IFN-b显著降低T细胞产生GM-CSF,为我们假设IFN-b抑制MS中T细胞产生GM-CSF提供了基础,这种抑制可能被证明是预测单个MS患者IFN-b治疗有效性的生物标志物。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

A.M. Rostami其他文献

A.M. Rostami的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('A.M. Rostami', 18)}}的其他基金

ThGM Cells in CNS Autoimmunity
中枢神经系统自身免疫中的 ThGM 细胞
  • 批准号:
    10449359
  • 财政年份:
    2021
  • 资助金额:
    $ 33.91万
  • 项目类别:
IL-37: a novel regulator of inflammation in CNS autoimmunity
IL-37:中枢神经系统自身免疫炎症的新型调节剂
  • 批准号:
    10199564
  • 财政年份:
    2021
  • 资助金额:
    $ 33.91万
  • 项目类别:
ThGM Cells in CNS Autoimmunity
中枢神经系统自身免疫中的 ThGM 细胞
  • 批准号:
    10299105
  • 财政年份:
    2021
  • 资助金额:
    $ 33.91万
  • 项目类别:
IL-37: a novel regulator of inflammation in CNS autoimmunity
IL-37:中枢神经系统自身免疫炎症的新型调节剂
  • 批准号:
    10369694
  • 财政年份:
    2021
  • 资助金额:
    $ 33.91万
  • 项目类别:
Oligodendrocyte extracellular vesicles: a novel therapy for CNS autoimmunity
少突胶质细胞外囊泡:中枢神经系统自身免疫的新疗法
  • 批准号:
    10115612
  • 财政年份:
    2020
  • 资助金额:
    $ 33.91万
  • 项目类别:
Role of IL-7R in CNS autoimmunity
IL-7R 在中枢神经系统自身免疫中的作用
  • 批准号:
    10308115
  • 财政年份:
    2020
  • 资助金额:
    $ 33.91万
  • 项目类别:
Oligodendrocyte extracellular vesicles: a novel therapy for CNS autoimmunity
少突胶质细胞外囊泡:中枢神经系统自身免疫的新疗法
  • 批准号:
    10361415
  • 财政年份:
    2020
  • 资助金额:
    $ 33.91万
  • 项目类别:
Mechanisms of GM-CSF effect in CNS autoimmune demyelination
GM-CSF在中枢神经系统自身免疫性脱髓鞘中的作用机制
  • 批准号:
    10062792
  • 财政年份:
    2016
  • 资助金额:
    $ 33.91万
  • 项目类别:
The Role of GM-CSF in the Pathogenesis of Multiple Sclerosis
GM-CSF 在多发性硬化症发病机制中的作用
  • 批准号:
    8911388
  • 财政年份:
    2014
  • 资助金额:
    $ 33.91万
  • 项目类别:
The role of IL-27 in iv tolerance in EAE
IL-27 在 EAE 静脉注射耐受中的作用
  • 批准号:
    8897994
  • 财政年份:
    2014
  • 资助金额:
    $ 33.91万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 33.91万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 33.91万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 33.91万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 33.91万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 33.91万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 33.91万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 33.91万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 33.91万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 33.91万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 33.91万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了