Comparative Effectiveness of Interventions for Depression in the Community

社区抑郁症干预措施的比较有效性

• 批准号: 8712419
• 负责人: Mary Beth Gibbons
• 金额: $ 15.51万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-02 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8712419
• 关键词: Comparative; Effectiveness; Interventions; Depression; Community

DESCRIPTION (provided by applicant): The goal of this independent research scientist award application is to protect the time necessary to further develop my skills as a newly independent researcher specializing in comparative effectiveness of interventions for depression in the community mental health system. This award would allow me to become a sophisticated comparative effectiveness researcher utilizing state-of-the-art methodologies and statistical approaches to study the effectiveness of interventions in alleviating mental health disorders of high public health priority. My program of research and planned career development activities are based on the definition of comparative effectiveness research elaborated by the Institute for Medicine's Committee on Comparative Effectiveness Research Prioritization. It is my goal to work with expert consultants and participate in training activities to take my comparative effectiveness research program to the next level. To complement my current program of research evaluating the effectiveness of interventions for depression in the community mental health system that inform clinical decision making at the population level, my goal is to develop expertise in methods and statistical approaches that would allow my research to address the important question of how to efficiently disseminate effective interventions to meet the needs of individual consumers of services for depression. This award would afford me the time needed to participate in classroom instruction in the newest statistical approaches, attend training seminars and institutes, work with expert consultants, and attend conferences to enhance my development as a comparative effectiveness researcher. This award would also allow me the time, expert consultation, and education needed to conduct two important studies to inform the efficient dissemination of interventions for depression in the community: a study of the patient baseline moderators of treatment effectiveness and a study of healthcare utilization and costs associated with the utilization of mental health interventions for MDD in the community mental health system. The specific aims of this investigation include 1) to assess whether patient baseline skills deficits moderate the effectiveness of dynamic therapy and cognitive therapy for patients with major depressive disorder treated in the community mental health setting, 2) to assess whether patient baseline deficits moderate the effectiveness of dynamic therapy and cognitive therapy on secondary measures of outcome, 3) to explore additional baseline patient variables that may moderate the effectiveness of these psychotherapeutic approaches for patients with major depressive disorder treated in the community mental health setting, and 4) to evaluate healthcare utilization and associated costs for patients treated with psychotherapy for depression in the community mental health system compared to patients who receive alternative treatments.

描述（由申请人提供）：这个独立研究科学家奖申请的目标是保护必要的时间，以进一步发展我作为一名新独立研究人员的技能，专门研究社区精神卫生系统中抑郁症干预措施的比较有效性。这个奖项将使我成为一名成熟的比较有效性研究人员，利用最先进的方法和统计方法来研究干预措施在减轻高度公共卫生优先事项的精神健康障碍方面的有效性。我的研究计划和规划的职业发展活动是基于医学研究所比较有效性研究优先级委员会（Committee on comparative effectiveness research priorities）对比较有效性研究的定义。我的目标是与专家顾问一起工作，并参加培训活动，将我的比较有效性研究项目提升到一个新的水平。为了补充我目前的研究项目，评估社区精神卫生系统中抑郁症干预措施的有效性，为人口水平的临床决策提供信息，我的目标是发展方法和统计方法方面的专业知识，使我的研究能够解决如何有效地传播有效的干预措施以满足抑郁症服务个人消费者的需求这一重要问题。这个奖项将为我提供必要的时间，参加最新统计方法的课堂教学，参加培训研讨会和研究所，与专家顾问合作，参加会议，以加强我作为比较有效性研究者的发展。这个奖项也会让我有时间、专家咨询和教育来进行两项重要的研究，为社区中抑郁症干预措施的有效传播提供信息：一项研究是对治疗效果的患者基线调节者的研究，另一项研究是对社区精神卫生系统中抑郁症心理健康干预措施的使用与医疗保健利用和成本的研究。本研究的具体目的包括：(1)评估患者基线技能缺陷是否会调节在社区精神卫生机构接受治疗的重度抑郁症患者的动态治疗和认知治疗的有效性；(2)评估患者基线缺陷是否会调节动态治疗和认知治疗对次要结果测量的有效性。3)探索其他基线患者变量，这些变量可能会调节这些心理治疗方法在社区精神卫生机构治疗的重度抑郁症患者的有效性；4)评估在社区精神卫生系统中接受心理治疗的抑郁症患者与接受替代治疗的患者的医疗保健利用和相关费用。