Advanced Skills Development in Glyco-Hematology and Glyco-Oncology

糖血液学和糖肿瘤学高级技能发展

• 批准号: 8949552
• 负责人: Umesh Ramanlal Desai
• 金额: $ 12.26万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-14 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8949552
• 关键词: Achievement; Address; Applications Grants; Area; Attention; Biochemistry; Biological; Biological Markers; Biology; Blood; Blood Cells; Blood Coagulation Factor; Blood Proteins; Cardiovascular Diseases; Cell Separation; Cells; Chemistry; Clinical; Development; Diagnostic; Disease; Educational Activities; Educational process of instructing; Future; Future Generations; Generic Drugs; Glycosaminoglycans; Hematology; Heparin; Human; Human Biology; Knowledge; Laboratories; Literature; Malignant Neoplasms; Medicine; Milk; Molecular Weight; National Research Council; Pharmaceutical Chemistry; Pharmacologic Substance; Pharmacy Students; Plague; Plasma; Polysaccharides; Postdoctoral Fellow; Procedures; Program Development; Property; Proteins; Recombinants; Reporting; Research; Research Personnel; Research Technics; Role; Scientist; Stem cells; Structure; Techniques; Technology; Therapeutic; Trademark; Training; Training Programs; Translational Research; United States National Academy of Sciences; Universities; Work; abstracting; cancer cell; cancer stem cell; career; education planning; experience; graduate student; innovation; interest; oncology; programs; research and development; skills

 DESCRIPTION (provided by applicant): The 2012 National Research Council (NRC) report titled `Transforming Glycoscience: A Roadmap for the Future' from the National Academy of Sciences, USA states that "Relatively little attention has been paid to this class of molecules, and glycoscience remains a relatively understudied field". The current RFA HL-15-006 attempts to address this state through development of creative educational activities that focus on "research area related to blood research, clinical procedures for research, or specialized research techniques. [e.g.] techniques for blood glycoscience, ... stem cell isolation/handling techniques " (see Section 1 of the RFA). In this grant application, we propose a skills development program that relies on a combination of didactic courses and hands-on research to train future generation scientists with expertise in the glycosciences of importance to hematology and oncology. Our program focuses on understanding structural and functional aspects of a) low and ultralow molecular weight heparins (LMWHs & ULMWHs) and b) N/O-glycans (NOGs) of blood proteins/cells. We proposed to 1) develop a research education plan that combines didactic teaching, literature analysis and hands-on research to train a cadre of graduate students and postdocs in the areas of glyco-hematology and glyco-oncology; 2) develop innovative research modules on structural and functional characterization of LMWHs/ULMWHs (modules 1 and 2) and NOGs of coagulation factors (module 3) and cancer stem cells (module 4); and 3) disseminate results and achievement in both skills development and research to enhance the impact of glycosciences in the biological and therapeutic arena. The combination of the teaching program proposed here with four highly innovative research modules is expected to impart the value of glycoscience to the young trainees, while also generating substantial new knowledge, technology and translational science that advances their careers. A distinguishing point about our program is its pharmaceutical/therapeutic (or translational) relevance. (End of Abstract)