Advanced Skills Development in Glyco-Hematology and Glyco-Oncology

 描述（由申请人提供）：2012年美国国家科学院国家研究理事会（NRC）题为“转化糖科学：未来路线图”的报告指出，“对这类分子的关注相对较少，糖科学仍然是一个相对研究不足的领域”。目前的RFA HL-15-006试图通过开发创新教育活动来解决这一问题，这些活动侧重于“与血液研究相关的研究领域、临床研究程序或专业研究技术”。[例如]血糖科学技术，干细胞分离/处理技术”（见RFA第1节）。在这项拨款申请中，我们提出了一项技能发展计划，该计划依赖于教学课程和实践研究的结合，以培养具有血液学和肿瘤学重要糖科学专业知识的未来一代科学家。我们的计划侧重于了解a）低和超低分子量肝素（LMWH & ULMWH）和B）血液蛋白/细胞的N/O-聚糖（NOG）的结构和功能方面。我们建议：1）制定一个研究教育计划，结合教学法教学，文献分析和实践研究，培养骨干的研究生和博士后在血糖血液学和血糖肿瘤学领域; 2）开发关于LMWH/ULMWH结构和功能表征的创新研究模块（模块1和2）以及凝血因子（模块3）和癌症干细胞（模块4）的NOG;以及3）传播技能发展和研究方面的成果和成就，以增强糖科学在生物和治疗竞技场的影响。这里提出的教学计划与四个高度创新的研究模块相结合，预计将向年轻的学员传授糖科学的价值，同时也产生大量的新知识，技术和转化科学，促进他们的职业生涯。关于我们的计划的一个区别点是它的药物/治疗（或翻译）相关性。(End摘要）

 DESCRIPTION (provided by applicant): The 2012 National Research Council (NRC) report titled `Transforming Glycoscience: A Roadmap for the Future' from the National Academy of Sciences, USA states that "Relatively little attention has been paid to this class of molecules, and glycoscience remains a relatively understudied field". The current RFA HL-15-006 attempts to address this state through development of creative educational activities that focus on "research area related to blood research, clinical procedures for research, or specialized research techniques. [e.g.] techniques for blood glycoscience, ... stem cell isolation/handling techniques " (see Section 1 of the RFA). In this grant application, we propose a skills development program that relies on a combination of didactic courses and hands-on research to train future generation scientists with expertise in the glycosciences of importance to hematology and oncology. Our program focuses on understanding structural and functional aspects of a) low and ultralow molecular weight heparins (LMWHs & ULMWHs) and b) N/O-glycans (NOGs) of blood proteins/cells. We proposed to 1) develop a research education plan that combines didactic teaching, literature analysis and hands-on research to train a cadre of graduate students and postdocs in the areas of glyco-hematology and glyco-oncology; 2) develop innovative research modules on structural and functional characterization of LMWHs/ULMWHs (modules 1 and 2) and NOGs of coagulation factors (module 3) and cancer stem cells (module 4); and 3) disseminate results and achievement in both skills development and research to enhance the impact of glycosciences in the biological and therapeutic arena. The combination of the teaching program proposed here with four highly innovative research modules is expected to impart the value of glycoscience to the young trainees, while also generating substantial new knowledge, technology and translational science that advances their careers. A distinguishing point about our program is its pharmaceutical/therapeutic (or translational) relevance. (End of Abstract)