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Time Perception and Timed Performance in Autism

自闭症患者的时间感知和定时表现

基本信息

批准号：
8911850
负责人：
Melissa J. Allman
金额：
$ 21.92万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-05 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8911850
关键词：
Age American Psychiatric Association Attention deficit hyperactivity disorder Autistic Disorder Award Awareness Behavior Behavior Therapy Behavioral Brain Cerebrum Clinical Code Cognition Cognitive Communication Coupled Data Detection Development Diagnosis Diagnostic tests Dimensions Discrimination Early Diagnosis Early Intervention Educational process of instructing Ensure Environment Event Expectancy Faculty Fingers Fostering Functional Magnetic Resonance Imaging Functional disorder Goals Impairment Individual Infant Instruction Intelligence Intervention Judgment Knowledge Laboratories Lead Learning Life Memory Mentors Methodology Motor Movement Nature Neuraxis Neurodevelopmental Disorder Neurologic Neurology Nonverbal Communication Pattern Perception Performance Persons Phase Physical environment Population Positioning Attribute Process Production Regulation Relative (related person)Reproduction Research Research Project Grants Research Training Rubia Schizophrenia Sensory Social Behavior Social Environment Social Interaction Socialization Speech Stereotyping Structure System Time Time Perception Training Training Programs Translations Triad Acrylic Resin Universities Vision Wing base biobehavior career career development cognitive development cognitive process improved infancy information processing interest joint attention medical schools millisecond neurobehavioral neurochemistry remediation response sensory integration social communication social skills sound theories time interval

项目摘要

DESCRIPTION (provided by applicant): The long term objective of this research is to improve the phenotypic characterization of autism by delineating the relative function of the interval timing system (ITS) in these individuals. The ITS is fundamental for adaptive cognitive and behavioral function, and there are theoretical, anecdotal and empirical grounds to suppose the ITS is dysfunctional in people with autism, and directly contributes to their triad of impairments. Only a handful of studies have assessed the ITS in autism, despite the fact that functioning of the ITS is being examined in other clinical populations (e.g., ADHD, schizophrenia). There are three specific aims of this research project that will fill gaps in our knowledge about autism, employing methodologies adapted from the basic laboratory (within the framework of scalar expectancy theory). The first aim (R00 phase) examines time perception (temporal bisection & generalization); the second aim (R00) examines timed performance (temporal reproduction & finger tapping); the third aim (K99 phase) employs fMRI to elucidate the neurological basis of preliminary data demonstrating quantifiable differences in time perception in autism (on temporal bisection; that correlates with scores on diagnostic tests). Results from K99/R00 studies will form the basis of an R01 application during the R00 cycle that will build upon the theoretical framework established during the K99 phase of the award and extend assessments of temporal information processing in autism. The support of a K99/R00 will provide the PI with mentored research training in developmental cognitive neurology, autism, fMRI (all at Johns Hopkins School of Medicine) and interval timing (with Dr. Warren Meck at Duke University), that extends and compliments her research background. Coupled with formal training classes, including autism diagnosis, this training plan will ensure the studies proposed during R00 can be successfully implemented. Research during the K99 phase will be conducted in the laboratory of Dr. Martha Denckla (primary mentor) who has a proven track record of supervising fellows into faculty positions. The proposed program of training and research will 'bridge' the transition to independence, and allow the PI to develop a unique and original line of autism research that will form the basis of her academic career.

描述（由申请人提供）：