Developmental Research Program

发展研究计划

• 批准号: 8932166
• 负责人: KEVIN M. SHANNON
• 金额: $ 10.45万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8932166
• 关键词: Advanced Malignant Neoplasm; Applications Grants; Area; California; Childhood; Cities; Collaborations; Data; Department of Defense; Development; Diagnosis; Diagnostic Neoplasm Staging; Disease; Early treatment; Evaluation; Faculty; Funding; Funding Agency; Germ Lines; Goals; Indiana; Institution; Malignant Neoplasms; Medical center; Mutation; NF1 gene; National Cancer Institute; North Carolina; Pathology; Pediatric Hospitals; Pennsylvania; Philadelphia; Pilot Projects; Population Sciences; Process; Recruitment Activity; Reproduction spores; Research; Research Activity; Research Personnel; Research Project Grants; Resources; San Francisco; Scientist; Site; Structure; Techniques; Texas; Therapeutic; Translational Research; Tumor stage; United States National Institutes of Health; Universities; abstracting; career development; high reward; high risk; improved; innovation; professor; programs; translational study; tumor

ABSTRACT – DEVELOPMENTAL RESEARCH PROGRAM The Developmental Hyperactive Ras Tumor (DHART) SPORE Developmental Research Program (DRP) will support innovative pilot projects to advance the diagnosis and treatment of early stage tumors and advanced cancers characterized by germ line and somatic NF1 mutations. The DRP will accomplish this goal by supporting rigorous translational research in the areas of population science, therapeutics, and mechanisms of disease. We expect that many investigators will utilize DRP support to generate preliminary data leading to successful grant applications to the NIH, the Department of Defense NF Research Program, and other funding agencies, thereby advancing research activities related to NF1-assocated tumors. The translational studies supported by the DRP will also have the potential to replace SPORE projects that have been completed or are not progressing satisfactorily toward achieving their objectives. One objective of the DRP is to fund established investigators who seek to develop a new research theme in the field of NF1-related cancers. This SPORE also includes a Career Development Program (CDP), which is described in a separate section of this application that has the complimentary goal of supporting junior investigators who wish to develop innovative research projects related to the goals of this SPORE. The institutions participating in this application have committed a total of $1.3 million to support the Developmental Programs component of the DHART SPORE (DRP and CDP). Investigators from any of these centers can apply for DRP funds, and we will also consider proposals from researchers at other institutions. The specific aims of the DRP are: (1) To support the development of new techniques and resources to advance translational research to improve the treatment of NF1-associated tumors; (2) to provide funds that will allow investigators to generate pilot feasibility data for grant applications to the NIH or other federal funding agencies; (3) to expand the scope of research in NF1-assocaited tumors with an emphasis on supporting high risk/high reward projects; and (4) to recruit talented investigators into NF1 research as it relates to cancer, and to promote new collaborations in this field through structured interactions with DHART SPORE investigator and assistance from the Administrative, Omics, and Biospecimen/Pathology Cores. The DRP will provide evaluation, funding, and oversight for a minimum of two pilot projects per year, with the potential for a single renewal. Each project will receive a minimum of $50,000 with a maximum of $75,000. Applications for DRP support (including requests for a second year of funding) will be evaluated through a competitive process with review by a Developmental Programs Steering Committee comprised on senor scientists participating in this SPORE and oversight and guidance from the External and Internal Advisory Boards.

摘要 - 发展研究计划 发育多动RAS肿瘤（DHART）孢子发育研究计划（DRP）将 支持创新的试点项目，以推动对早期肿瘤的诊断和治疗 以生殖系和体细胞NF1突变为特征的癌症。 DRP将通过 支持人口科学，治疗领域的严格转化研究和机制 疾病。我们希望许多调查人员会利用DRP支持来生成初步数据，从而 成功地向NIH，国防部NF研究计划和其他资金申请授予申请 机构，从而推进与NF1相关肿瘤有关的研究活动。翻译研究 由DRP支持还将有可能替换已完成或正在的孢子项目 没有令人满意地实现自己的目标。 DRP的一个目标是资助已建立的 试图在NF1相关癌症领域开发新研究主题的研究人员。这也是孢子 包括职业发展计划（CDP），该计划在本申请的单独部分中进行了描述 这具有支持希望开发创新研究的初级调查人员的免费目标 与该孢子的目标有关的项目。参加此申请的机构已承诺 总计130万美元，以支持Dhart Spore的发展计划部分（DRP和 CDP）。这些中心的调查人员都可以申请DRP资金，我们还将考虑提案 来自其他机构的研究人员。 DRP的具体目的是：（1）支持开发 新技术和资源以推进转化研究以改善与NF1相关的处理 肿瘤； （2）提供资金，以允许调查人员为赠款申请生成试点可行性数据 NIH或其他联邦资助机构； （3）扩大NF1分配肿瘤的研究范围 强调支持高风险/高奖励项目； （4）将有才华的调查员招募到NF1 与癌症有关的研究，并通过结构化互动来促进该领域的新合作 在Dhart Spore研究者和行政，OMIC和BIOSPECEMEN/病理学的帮助下 内核。 DRP每年至少两个试点项目提供评估，资金和监督， 具有单个续约的潜力。每个项目将最低$ 50,000，最高为50,000美元 $ 75,000。将评估DRP支持的申请（包括第二年的资金请求） 通过竞争过程，开发计划指导委员会的审查完成了 参与外部和内部的孢子的科学家参加了这一孢子，监督和指导 咨询委员会。