Developmental Research Program

发展研究计划

• 批准号: 8932166
• 负责人: KEVIN M. SHANNON
• 金额: $ 10.45万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8932166
• 关键词: Advanced Malignant Neoplasm; Applications Grants; Area; California; Childhood; Cities; Collaborations; Data; Department of Defense; Development; Diagnosis; Diagnostic Neoplasm Staging; Disease; Early treatment; Evaluation; Faculty; Funding; Funding Agency; Germ Lines; Goals; Indiana; Institution; Malignant Neoplasms; Medical center; Mutation; NF1 gene; National Cancer Institute; North Carolina; Pathology; Pediatric Hospitals; Pennsylvania; Philadelphia; Pilot Projects; Population Sciences; Process; Recruitment Activity; Reproduction spores; Research; Research Activity; Research Personnel; Research Project Grants; Resources; San Francisco; Scientist; Site; Structure; Techniques; Texas; Therapeutic; Translational Research; Tumor stage; United States National Institutes of Health; Universities; abstracting; career development; high reward; high risk; improved; innovation; professor; programs; translational study; tumor

ABSTRACT – DEVELOPMENTAL RESEARCH PROGRAM The Developmental Hyperactive Ras Tumor (DHART) SPORE Developmental Research Program (DRP) will support innovative pilot projects to advance the diagnosis and treatment of early stage tumors and advanced cancers characterized by germ line and somatic NF1 mutations. The DRP will accomplish this goal by supporting rigorous translational research in the areas of population science, therapeutics, and mechanisms of disease. We expect that many investigators will utilize DRP support to generate preliminary data leading to successful grant applications to the NIH, the Department of Defense NF Research Program, and other funding agencies, thereby advancing research activities related to NF1-assocated tumors. The translational studies supported by the DRP will also have the potential to replace SPORE projects that have been completed or are not progressing satisfactorily toward achieving their objectives. One objective of the DRP is to fund established investigators who seek to develop a new research theme in the field of NF1-related cancers. This SPORE also includes a Career Development Program (CDP), which is described in a separate section of this application that has the complimentary goal of supporting junior investigators who wish to develop innovative research projects related to the goals of this SPORE. The institutions participating in this application have committed a total of $1.3 million to support the Developmental Programs component of the DHART SPORE (DRP and CDP). Investigators from any of these centers can apply for DRP funds, and we will also consider proposals from researchers at other institutions. The specific aims of the DRP are: (1) To support the development of new techniques and resources to advance translational research to improve the treatment of NF1-associated tumors; (2) to provide funds that will allow investigators to generate pilot feasibility data for grant applications to the NIH or other federal funding agencies; (3) to expand the scope of research in NF1-assocaited tumors with an emphasis on supporting high risk/high reward projects; and (4) to recruit talented investigators into NF1 research as it relates to cancer, and to promote new collaborations in this field through structured interactions with DHART SPORE investigator and assistance from the Administrative, Omics, and Biospecimen/Pathology Cores. The DRP will provide evaluation, funding, and oversight for a minimum of two pilot projects per year, with the potential for a single renewal. Each project will receive a minimum of $50,000 with a maximum of $75,000. Applications for DRP support (including requests for a second year of funding) will be evaluated through a competitive process with review by a Developmental Programs Steering Committee comprised on senor scientists participating in this SPORE and oversight and guidance from the External and Internal Advisory Boards.

摘要-医学研究 Ras肿瘤发育过度活跃症（DHART）孢子发育研究计划（DRP）将 支持创新试点项目，以推进早期肿瘤的诊断和治疗， 以生殖系和体细胞NF 1突变为特征的癌症。DRP将通过以下方式实现这一目标： 支持人口科学、治疗学和疾病机制领域的严格转化研究。 疾病我们预计，许多研究者将利用DRP支持生成初步数据， 成功申请NIH、国防部NF研究计划和其他资金 从而推进与NF 1相关肿瘤相关的研究活动。翻译研究 在DRP的支持下，还将有可能取代已经完成或正在 在实现其目标方面进展不令人满意。DRP的一个目标是为建立 研究人员寻求在NF 1相关癌症领域开发新的研究主题。这个孢子也 包括职业发展计划（CDP），该计划在本申请的单独部分中描述 它的目标是支持那些希望开展创新研究的初级研究人员 与此目标相关的项目。参与这项申请的院校已承诺 总计130万美元，用于支持DHART SPORE的发展计划部分（DRP和 CDP）。来自这些中心的任何一个的调查人员都可以申请DRP资金，我们也将考虑有关建议 其他机构的研究人员。该方案的具体目标是：（1）支持发展 新的技术和资源，以推进转化研究，以改善治疗NF 1相关 （2）提供资金，使研究人员能够为赠款申请生成试点可行性数据， 美国国立卫生研究院或其他联邦资助机构;（3）扩大NF 1相关肿瘤的研究范围， 重点支持高风险/高回报项目;（4）招募有才能的调查人员进入NF 1 与癌症有关的研究，并通过结构化的互动促进这一领域的新合作 与DHART SPORE研究者一起，并在管理、组学和生物标本/病理学方面提供协助 丹DRP将每年至少为两个试点项目提供评估、资金和监督， 有可能一次续约每个项目将获得最低5万美元，最高 七万五将评估DRP支持申请（包括第二年资助申请） 通过竞争过程，并由发展计划指导委员会进行审查， 参与该SPORE的高级科学家以及外部和内部的监督和指导 咨询委员会。