Developmental Research Program

发展研究计划

• 批准号: 8932166
• 负责人: KEVIN M. SHANNON
• 金额: $ 10.45万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8932166
• 关键词: Advanced Malignant Neoplasm; Applications Grants; Area; California; Childhood; Cities; Collaborations; Data; Department of Defense; Development; Diagnosis; Diagnostic Neoplasm Staging; Disease; Early treatment; Evaluation; Faculty; Funding; Funding Agency; Germ Lines; Goals; Indiana; Institution; Malignant Neoplasms; Medical center; Mutation; NF1 gene; National Cancer Institute; North Carolina; Pathology; Pediatric Hospitals; Pennsylvania; Philadelphia; Pilot Projects; Population Sciences; Process; Recruitment Activity; Reproduction spores; Research; Research Activity; Research Personnel; Research Project Grants; Resources; San Francisco; Scientist; Site; Structure; Techniques; Texas; Therapeutic; Translational Research; Tumor stage; United States National Institutes of Health; Universities; abstracting; career development; high reward; high risk; improved; innovation; professor; programs; translational study; tumor

ABSTRACT – DEVELOPMENTAL RESEARCH PROGRAM The Developmental Hyperactive Ras Tumor (DHART) SPORE Developmental Research Program (DRP) will support innovative pilot projects to advance the diagnosis and treatment of early stage tumors and advanced cancers characterized by germ line and somatic NF1 mutations. The DRP will accomplish this goal by supporting rigorous translational research in the areas of population science, therapeutics, and mechanisms of disease. We expect that many investigators will utilize DRP support to generate preliminary data leading to successful grant applications to the NIH, the Department of Defense NF Research Program, and other funding agencies, thereby advancing research activities related to NF1-assocated tumors. The translational studies supported by the DRP will also have the potential to replace SPORE projects that have been completed or are not progressing satisfactorily toward achieving their objectives. One objective of the DRP is to fund established investigators who seek to develop a new research theme in the field of NF1-related cancers. This SPORE also includes a Career Development Program (CDP), which is described in a separate section of this application that has the complimentary goal of supporting junior investigators who wish to develop innovative research projects related to the goals of this SPORE. The institutions participating in this application have committed a total of $1.3 million to support the Developmental Programs component of the DHART SPORE (DRP and CDP). Investigators from any of these centers can apply for DRP funds, and we will also consider proposals from researchers at other institutions. The specific aims of the DRP are: (1) To support the development of new techniques and resources to advance translational research to improve the treatment of NF1-associated tumors; (2) to provide funds that will allow investigators to generate pilot feasibility data for grant applications to the NIH or other federal funding agencies; (3) to expand the scope of research in NF1-assocaited tumors with an emphasis on supporting high risk/high reward projects; and (4) to recruit talented investigators into NF1 research as it relates to cancer, and to promote new collaborations in this field through structured interactions with DHART SPORE investigator and assistance from the Administrative, Omics, and Biospecimen/Pathology Cores. The DRP will provide evaluation, funding, and oversight for a minimum of two pilot projects per year, with the potential for a single renewal. Each project will receive a minimum of $50,000 with a maximum of $75,000. Applications for DRP support (including requests for a second year of funding) will be evaluated through a competitive process with review by a Developmental Programs Steering Committee comprised on senor scientists participating in this SPORE and oversight and guidance from the External and Internal Advisory Boards.

摘要——发展研究计划 发育性过度活跃 Ras 肿瘤 (DHART) SPORE 发育研究计划 (DRP) 将 支持创新试点项目，推进早期肿瘤和晚期肿瘤的诊断和治疗 以种系和体细胞 NF1 突变为特征的癌症。 DRP 将通过以下方式实现这一目标 支持人口科学、治疗学和机制等领域的严格转化研究 疾病。我们预计许多研究人员将利用 DRP 支持来生成初步数据，从而 成功向 NIH、国防部 NF 研究计划和其他资金申请拨款 机构，从而推进与 NF1 相关肿瘤相关的研究活动。转化研究 DRP 支持的项目也将有可能取代已经完成或正在开发的 SPORE 项目 在实现目标方面没有取得令人满意的进展。 DRP 的目标之一是资助已建立的 寻求在 NF1 相关癌症领域开发新研究主题的研究人员。这个孢子也 包括职业发展计划 (CDP)，该计划在本申请的单独部分中进行了描述 其另一个目标是支持希望开展创新研究的初级研究人员 与该 SPORE 目标相关的项目。参与本申请的机构已承诺 总计 130 万美元用于支持 DHART SPORE 的发展计划部分（DRP 和 中国民主党）。这些中心的研究人员都可以申请 DRP 资金，我们也会考虑提案 来自其他机构的研究人员。 DRP的具体目标是：（1）支持发展 新技术和资源推进转化研究，改善 NF1 相关疾病的治疗 肿瘤； (2) 提供资金，使调查人员能够为赠款申请生成试点可行性数据 NIH 或其他联邦资助机构； (3) 扩大 NF1 相关肿瘤的研究范围 强调支持高风险/高回报项目； (4) 招募有才华的研究人员加入 NF1 与癌症相关的研究，并通过结构化互动促进该领域的新合作 与 DHART SPORE 调查员合作，并获得行政、组学和生物样本/病理学的协助 核心。 DRP 每年将为至少两个试点项目提供评估、资助和监督， 具有单次续订的潜力。每个项目将获得最少 50,000 美元，最多 75,000 美元。 DRP 支持申请（包括第二年资助请求）将接受评估 通过由发展计划指导委员会组成的竞争性程序进行审查 参与本次 SPORE 的资深科学家以及外部和内部的监督和指导 顾问委员会。