Career Enhancement Program

摘要-职业魅力 该DHART孢子职业提升计划（CEP）支持教师在教师和助理 教授级从事翻译研究，重点是NF 1/Rasopathy疾病和癌症。的 CEP的主要目标是促进早期研究人员的职业发展， 与实施更有效和毒性更小的癌症治疗目标相关的研究， NF1/Ras。这个SPORE的多机构性质利用了大量有才华的早期职业生涯 来自多个学科的教师。每个机构都将CEP视为招募和提升 早期翻译科学家的职业生涯。他们共同承诺向目前的 这笔奖金和165万美元用于支持DHART SPORE（CEP）的发展计划 的DRP）。CEP的具体目标是：（1）支持早期阶段的研究人员，因为他们的发展 创新的研究计划，为NF 1相关的癌症研究提供新的知识， 初步数据，将允许成功的未来独立的校外资助;（2）提供早期阶段 研究人员接受培训，使他们具备独立成功的基本技能和知识 研究人员;以及，（3）通过定期安排的一对一指导早期翻译研究人员 指导会议和结构化的个人发展计划（IDP），以促进融入结构 的孢子。临时选举委员会特别强调支持征聘代表性不足的少数族裔 调查员（URM）。DHART SPORE将与所有的多样性计划进行垂直和水平的联系， 联盟机构，并确保最大限度地暴露CEP的指导和资助机会， 在七个DHART SPORE站点上的URM。此外，申请请求（RFA）将与 历史上黑人学院和大学以及代表社区的专业组织- 在生物医学科学中有代表性。RFA已通过 儿童肿瘤基金会和神经纤维瘤病治疗加速计划。我们正在扩大 这项招募工作包括神经肿瘤学会，RASopathies网络美国，儿童的 肿瘤组。目标是每年资助两个CEP提案（每个提案50 000 - 75 000美元）。请求 申请将每年两次通过广泛的沟通，以最大限度地提高上述所有团体的 招聘各种科学家和科学的机会。CEP机会也将在 全年专业会议。CEP支持的申请将通过 竞争过程，并由发展计划指导委员会进行审查， 来自DHART SPORE的科学家在SPORE外部和内部的监督和指导下， 咨询委员会。

ABSTRACT– CAREER ENCHANCEMENT PROGRAM The DHART SPORE Career Enhancement Program (CEP) supports faculty at the Instructor and Assistant Professor levels to engage in translational research focused on NF1/Rasopathy disorders and cancer. The primary goal of the CEP is to advance the careers of early stage investigators who are developing innovative research related to the goal of implementing more effective and less toxic therapies for cancers characterized by NF1/Ras. The multi-institutional nature of this SPORE leverages a large and talented pool of early career faculty from multiple disciplines. Each institution views the CEP as a vehicle for recruiting and advancing the careers of early stage translational scientists. Collectively, they have committed $1.3 million to the current award and $1.65 million to the renewal to support the Developmental Programs of the DHART SPORE (CEP and DRP). The Specific Aims of the CEP are to: (1) support early stage investigators as they develop innovative research programs that contribute new knowledge to NF1-related cancer research while generating preliminary data that will allow successful future independent extramural funding; (2) provide early stage researchers with training that will equip them with essential skills and knowledge for success as independent investigators; and, (3) mentor early stage translational researchers through regularly scheduled one-on-one mentor meetings and a structured Individual Development Program (IDP) to facilitate integration into the fabric of the SPORE. The CEP has a special emphasis on supporting the recruitment of underrepresented minority investigators (URM). The DHART SPORE will link vertically and horizontally with diversity programs at all of the consortium institutions and ensure maximum exposure of the CEP mentorship and funding opportunities to URM across the seven DHART SPORE sites. Further, requests for applications (RFA) will be shared with Historically Black Colleges and Universities and professional organizations representing communities under- represented in biomedical science. RFAs are already sent outside of the DHART SPORE sites via the Children’s Tumor Foundation and Neurofibromatosis Therapeutic Acceleration Program. We are expanding this recruitment effort to include the Society for Neuro-Oncology, RASopathies Network USA, the Children’s Oncology Group. The goal is to fund two CEP proposals per year ($50,000 - $75,000/proposal). Requests for applications will be announced twice a year via broad communications to all groups listed above to maximize opportunities for recruitment of diverse scientists and science. CEP opportunities will also be highlighted at professional meetings throughout the year. Applications for CEP support will be evaluated through a competitive process with review by a Developmental Programs Steering Committee comprised of senor scientists from the DHART SPORE with oversight and guidance from the SPORE External and Internal Advisory Boards.