Neurophysiological and Psychological Correlates of Vulvodynia
外阴痛的神经生理学和心理相关性
基本信息
- 批准号:8647866
- 负责人:
- 金额:$ 3.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-03-01 至 2018-02-28
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAffectAffectiveAgeApplications GrantsBiologicalBiological FactorsBody ImageBurn injuryCharacteristicsChronicClinicalCognitionCognitiveComplexDataDetectionDevelopmentDiseaseEconomic BurdenEducational StatusElementsEthnic OriginEtiologyFamilyFemaleFoundationsFrightFundingFutureGeneticGenital systemGenitourinary systemGoalsHealth Care CostsHealthcareHealthcare SystemsInterventionInvestigationInvestigational TherapiesKnowledgeLeadLearningMaintenanceMeasuresMental DepressionMentorsMethodsMissionNeurobiologyOnset of illnessPainPain DisorderPain ResearchPain-FreePatient CarePatient Self-ReportPatientsPatternPerceptionPeripheralPhysiologicalPhysiologyPopulationProcessProductivityPsychological FactorsQuality of lifeRaceRecording of previous eventsReportingResearchResearch DesignResearch PersonnelResearch Project GrantsSensorySensory ProcessSexual DysfunctionSocial FunctioningSocietiesSocioeconomic StatusSting InjuryStrategic PlanningStressSubgroupSymptomsSyndromeTestingTherapeuticTrainingTreatment/Psychosocial EffectsUnited States National Institutes of HealthVulvaVulvodyniaWomanWomen&aposs GroupWorkbasechronic paincostdesigneffective therapyexperienceimprovedmechanical pressureneurophysiologynew therapeutic targetnovelnovel therapeutic interventionpatient orientedpatient populationprogramspsychologicpublic health relevanceresponsesocialtreatment strategyvibrationvulvar pain
项目摘要
DESCRIPTION (provided by applicant): Vulvodynia is a multifaceted, chronic, female urogenital pain syndrome that is understudied and carries a substantial psychological and economic burden for women and their families, the healthcare system, and society. Similar to other chronic pain syndromes, the development and maintenance of vulvodynia symptomatology is most likely a complex combination of biological and psychological factors; however, these mechanisms are not well-described or understood and effective treatment remains elusive. An increased understanding of the respective contribution of each of these elements will impart critical information about vulvodynia and provide the crucial first steps for the development of mechanistic-based interventions. In recent years, studies have suggested the underlying mechanisms may vary amongst the multifarious clinical presentations of vulvodynia. Therefore, the purpose of this descriptive study is to thoroughly elucidate the physiological and psychological factors associated with vulvodynia in comparison to women without and test the hypothesis that these mechanisms differ in women with distinct patterns of disease onset, specifically primary (i.e., has always experienced vulvar pain) and secondary (i.e., development of pain following a pain free period) vulvodynia. First, the applicant will assess the neurosensory processing using a comprehensive battery of quantitative sensory testing (QST) methods in 20 women with primary vulvodynia, 20 women with secondary vulvodynia, and 20 age and race matched women without vulvodynia. Training will focus on increasing knowledge in neurophysiology and learning experimental methods in pain research. Second, the applicant will assess psychological factors using self-report measures of fear of pain and catastrophizing (i.e., negative cognitive-affective response to anticipated or actual pain) in the three groups of women. Training will focus on learning methods to accurately assess these psychological factors in a chronic vulvar pain population. A team of senior mentors with expertise in the experimental investigation of neurosensory processing of chronic pain and the neurobiology of urogenital pain disorders will guide the applicant in the proposed research project and throughout her doctoral training. The proposed research aligns well with the NINR's mission to examine the underlying biological mechanisms of symptoms (e.g., pain) associated with disease. Ultimately, findings from this study will inform our knowledge about vulvodynia and will provide direction for future research with regard to development of novel targeted therapies for treatment of vulvodynia.
描述(由申请人提供):外阴疼痛是一种多方面的慢性女性泌尿生殖道疼痛综合征,研究不足,给女性及其家庭、医疗保健系统和社会带来了巨大的心理和经济负担。与其他慢性疼痛综合征类似,外阴疼痛的发生和维持很可能是生物学和心理学因素的复杂组合;然而,这些机制尚未得到充分描述或理解,有效的治疗仍然难以实现。增加对这些元素各自贡献的理解将传授有关外阴痛的关键信息,并为开发基于机制的干预措施提供关键的第一步。近年来,研究表明外阴痛的潜在机制可能因临床表现而异。因此,这项描述性研究的目的是彻底阐明与外阴痛相关的生理和心理因素,与没有外阴痛的女性相比,并检验这些机制在具有不同疾病发作模式的女性中不同的假设,特别是原发性(即,总是经历外阴疼痛)和继发性(即,无痛期后疼痛的发展)外阴痛。首先,申请方将使用一组全面的定量感觉测试(QST)方法评估20名原发性外阴痛女性、20名继发性外阴痛女性和20名年龄和种族匹配的无外阴痛女性的神经感觉处理。培训将侧重于增加神经生理学知识和学习疼痛研究的实验方法。其次,申请人将使用对疼痛和灾难化恐惧的自我报告措施来评估心理因素(即,对预期或实际疼痛的负面认知情感反应)。培训将侧重于学习方法,以准确评估慢性外阴疼痛人群中的这些心理因素。在慢性疼痛的神经感觉处理的实验研究和泌尿生殖系统疼痛疾病的神经生物学的专业知识的高级导师团队将指导申请人在拟议的研究项目,并在整个她的博士培训。拟议的研究与NINR的使命非常一致,即检查症状的潜在生物学机制(例如,疼痛)与疾病有关。最终,这项研究的结果将为我们了解外阴痛提供信息,并为未来关于开发治疗外阴痛的新型靶向疗法的研究提供方向。
项目成果
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