5th ASM Conference on Cell-Cell Communication in Bacteria

描述（由申请人提供）：细菌是单细胞生命的范例，但它们也表现出复杂的协调行为，往往违背单细胞性。过去二十年的研究表明，各种细菌可以通过不同的机制进行交流。在大多数情况下，这些微生物的对话是通过交换可扩散的信号进行的，尽管也有明显的依赖接触的通信的例子。许多微生物利用这些信号机制来监测和响应种群密度，这一过程通常被称为群体感应。然而，细菌间的通信并不局限于群体感应机制，越来越多的证据表明，信号可以在一系列不同的能力。微生物之间的交流对宿主相互作用有着深远的影响，因为病原体和寄生虫经常通过信号产生和感知来调节与宿主相互作用的关键因素。本申请要求对第五届美国微生物学会主办的细菌细胞间通讯会议提供财政支持，该会议将于2014年10月18日至21日在德克萨斯州圣安东尼奥举行。细菌细胞间通讯的研究汇集了多种科学家，包括微生物学家、结构生物学家、系统和合成生物学家、数学家、化学家、生物化学家和生态学家。此外，对信号机制的关注超越了生物体之间以及“医学”和“非医学”微生物学之间的历史界限。CCCB会议的目标是为在这个快速发展但成熟的研究领域工作的研究人员提供一个独特的论坛，讨论，传播和交流新的信息和想法。会议安排围绕主题，如：信号的产生和感知;信号干扰作为一种新的治疗策略;信号在发展中的作用;宿主-病原体相互作用和信号;研究信号的系统方法;信号在共生和互惠中的作用;和生态学和信号的进化。本次会议的目标是作为一个管道，为美国和国际领先的科学家之间的细菌通信工作的新思想的交流和合成，以培养下一代科学家在这一领域的工作，并吸引其他研究人员（特别是那些在系统和合成生物学，微生物发病机理和化学）到这个令人兴奋的领域。预计这次会议将刺激和扩大细胞间通信社区，导致杰出的话语和富有成效的新合作。

DESCRIPTION (provided by applicant): Bacteria are the paradigm for unicellular life, yet they also exhibit elaborate coordinated behaviors that often defy unicellularity. Research over the past two decades has revealed that a wide range of bacteria can communicate by diverse mechanisms. In most cases these microbial conversations occur through the exchange of diffusible signals, although there are also clear examples of contact-dependent communication. Many microbes use these signaling mechanisms to monitor and respond to population density, a process often described as quorum sensing. Interbacterial communication is not however restricted to quorum sensing mechanisms and there is mounting evidence that signaling can function in a range of different capacities. Communication between microorganisms has profound impacts on host interactions, as pathogens and commensals often regulate factors critical for interaction with their hosts via signal production and perception. This application requests financial support for the fifth American Society for Microbiology-sponsored conference on Cell-cell Communication in Bacteria, to be held from October 18 - 21, 2014 in San Antonio, Texas. Research on cell-cell communication in bacteria brings together a diversity of scientists, including microbiologists, structural biologists, systems and synthetic biologists, mathematicians, chemists, biochemists, and ecologists. Furthermore, the focus on signaling mechanisms transcends historical boundaries between organisms, and between "medical" and "non-medical" microbiology. The goal of the CCCB conference is to provide a unique forum for the discussion, dissemination and exchange of new information and ideas among researchers working within this rapidly developing, yet mature research area. Sessions are arranged around topics such as: signal generation and perception; signal interference as a novel therapeutic strategy; the role of signaling in development; host-pathogen interactions and signaling; systems approaches to studying signaling; the role of signaling in symbiosis and mutualism; and ecology and evolution of signaling. The goal of this conference is to act as a conduit for the exchange and synthesis of new ideas among leading US and international scientists working on bacterial communication, to foster the next generation of scientists to work in this area, and to attract other researchers (particularly those in systems and synthetic biology, microbial pathogenesis, and chemistry) to this exciting field. It is anticipated that this conference will stimulate and expand the cell-cell communication community, leading to outstanding discourse and productive new collaborations.