Longitudinal Associations between Obesity and Depression: A Community-Based Study

肥胖与抑郁之间的纵向关联：一项基于社区的研究

• 批准号: 8638347
• 负责人: NAOMI R MARMORSTEIN
• 金额: $ 20.98万
• 依托单位: RUTGERS THE STATE UNIV OF NJ CAMDEN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8638347
• 关键词: 11 year old; 4 year old; Address; Adolescent; Age; Body mass index; Childhood; Clinical; Clinical assessments; Communities; Comorbidity; Conflict (Psychology); Data; Development; Diagnosis; Disease; Distress; Early treatment; Environment; Family; Family Study; Family member; Future; Generations; Genes; Genetic; Healthcare; Height; Individual; Lead; Link; Literature; Longitudinal Studies; Major Depressive Disorder; Measures; Mental Depression; Minnesota; Monozygotic Twinning; Monozygotic twins; Nature; Obesity; Overweight; Parents; Patient Self-Report; Persons; Physiological; Population; Prevention; Prevention program; Productivity; Public Health; Reliance; Research; Risk; Sample Size; Sampling; Societies; Symptoms; Time; Twin Multiple Birth; Weight; Weight Gain; Youth; adolescent offspring; base; cost; depressive symptoms; design; early adolescence; emerging adult; experience; follow-up; improved; innovation; interest; offspring; prevent; prospective; psychologic; public health relevance

DESCRIPTION (provided by applicant): Obesity and major depressive disorder (MDD) are increasingly common and pose enormous costs to individuals and society in the forms of health-care expenses, lost productivity, and personal distress. These disorders co-occur at rates greater than chance, though the specifics of how, among whom, and why remain unclear. This project will approach this issue in three different ways. In Aim #1, using a longitudinal prospective design, the degree to which earlier MDD predicts the onset of later obesity and the degree to which earlier obesity predicts the onset of later MDD will be examined during the period from childhood through early adulthood; this will enable us to identify periods of particula risk for the development of this comorbidity. In Aim #2, associations between these disorders within families will be examined by determining how MDD and obesity in parents are associated with risk for these same disorders in late-adolescent offspring. In Aim #3, possible causal associations between MDD and obesity will be investigated using longitudinal co-twin control and co-twin difference designs. In the co-twin control designs, twin pairs in which one has the disorder of interest (e.g., MDD) and the other does not are followed over time to examine the development of another disorder (e.g., obesity). If the twin with the earlier disorder is at increased risk for the later disorder compared to the co-twin without the disorder, this points to the earlier disorder creating an experiential context with a causal influence on the development of the later disorder. If the twin without the initial disorder shows risk for the later disorder tat is equivalent to that of the co-twin with the initial disorder, this points to the likelihood that oneis not part of the causal chain for the development of the other. Discordant monozygotic twins are particularly informative because they share both the same genetic make-ups and rearing environments. Co-twin difference analyses extend the co-twin control design by utilizing these same principles to maximize statistical power by using the entire sample and dimensional measures of body mass index and MDD symptoms. To address these Aims, archival data from the Minnesota Twin Family Study will be used. This is a community-based sample of twins and their parents, with clinical assessments of MDD and obesity every 3-4 years from ages 11 to 29 (up to 6 time points) in the youth, as well as clinical assessments of MDD and obesity in their parents. The youth sample sizes at different ages range from 2,510 to 3,762, with follow-up rates above 87% at each assessment. In addition, data are available on 3,622 parents. To maximize both public health impact and statistical power, both dimensional and categorical analyses are planned. By elucidating longitudinal associations between MDD and obesity, the associations between these disorders within families, and the potential causal paths between these disorders, this project has a high likelihood of yielding an improved understanding of these associations.

描述（由申请人提供）：肥胖和重度抑郁症（MDD）越来越常见，并以医疗保健费用，生产力损失和个人痛苦的形式给个人和社会带来巨大的成本。这些疾病同时发生的几率大于偶然性，但具体如何发生、发生在谁身上以及为什么发生仍不清楚。本项目将以三种不同的方式处理这一问题。在目标#1中，使用纵向前瞻性设计，将在儿童期至成年早期期间检查早期MDD预测晚期肥胖发作的程度以及早期肥胖预测晚期MDD发作的程度;这将使我们能够确定这种合并症发展的特定风险期。在目标#2中，将通过确定父母的MDD和肥胖如何与青春期后期后代中这些相同疾病的风险相关来检查家庭中这些疾病之间的关联。在目标3中，将使用纵向双胞胎对照和双胞胎差异设计研究MDD和肥胖之间可能的因果关系。在共双胞胎对照设计中，其中一个患有感兴趣的疾病的双胞胎对（例如，MDD）和另一种不随时间推移进行随访以检查另一种疾病的发展（例如，肥胖症）。如果双胞胎与早期疾病是在增加的风险，为后来的障碍相比，共同双胞胎没有障碍，这表明早期的障碍创造了一个经验的背景下，因果关系的影响发展的后来的障碍。如果没有最初疾病的双胞胎显示出患晚期疾病的风险达特与患有最初疾病的双胞胎的风险相当，这表明一个可能不是另一个发展的因果链的一部分。不一致的单卵双胞胎特别有用，因为他们有着相同的基因组成和养育环境。双胞胎差异分析扩展了双胞胎对照设计，利用这些相同的原则，通过使用整个样本和体重指数和MDD症状的维度测量来最大化统计功效。 为了实现这些目标，将使用明尼苏达州双胞胎家庭研究的档案数据。这是一个以社区为基础的双胞胎及其父母样本，从11岁到29岁（最多6个时间点），每3-4年对青少年的MDD和肥胖进行一次临床评估，以及对其父母的MDD和肥胖进行临床评估。不同年龄段的青年样本量从2，510到3，762不等，每次评估的随访率都在87%以上。此外，还有3 622名家长的数据。为了最大限度地提高公共卫生影响和统计能力，计划进行维度和分类分析。 通过阐明MDD和肥胖之间的纵向关联，家庭内这些疾病之间的关联，以及这些疾病之间的潜在因果关系，该项目很有可能提高对这些关联的理解。