Longtudinal Relations Between Internalizing Disorders and Substance Use Problems

描述（由申请人提供）：本研究职业发展奖（K 01）的目标是为PI提供为期5年的课程，并在复杂的纵向数据分析技术和数据收集领域进行指导研究，以便她发展必要的专业知识，以追求独立的研究职业检查内化障碍和物质使用和障碍之间的关联。第一个培训目标侧重于获得一些纵向统计分析技术的专业知识（例如，增长曲线建模，潜在的过渡分析），并将通过课程和指导研究相结合来实现。这些技术最初将被应用到两个纵向档案数据集，明尼苏达州双胞胎家庭研究和匹兹堡青年研究（1-4年）。第二个培训目标涉及指导数据收集;将对新泽西卡姆登的弱势青年样本进行频繁评估（4-5年级）。在这个职业发展奖的第5年，PI将把她的统计专业知识应用到她自己的卡姆登研究的纵向数据中，并申请R 01补助金，以扩大她的卡姆登纵向研究，并研究与精神病理学和物质使用问题有关的新问题。 拟议的研究探讨了内化障碍（抑郁症，广泛性焦虑和社交焦虑）与物质使用和障碍（滥用和依赖）之间的纵向关联。直接检查这些协会的两个重要的潜在主持人-性别和反社会行为-将被包括在内，并被视为至关重要的发展和这些问题之间的纵向路径的准确理解。通过使用复杂的纵向统计技术，既以变量为中心，又以人为中心，并通过使用三个互补的数据集，在这个职业发展奖的5年期间进行的研究将导致内化障碍和物质使用和障碍之间的纵向关联的综合模型，并将使PI能够进行独立的，高生产力的研究计划，推动该领域更深入，更彻底地了解随着时间的推移，精神病理学和物质使用问题之间的关联。 这项研究对公共卫生很重要，因为清楚地了解精神健康和物质使用问题之间的联系将导致更有效和有针对性的预防和干预工作，从而减轻精神疾病和物质使用问题对社会的负担。

DESCRIPTION (provided by applicant): The goal of this Research Career Development Award (K01) is to provide the PI with a 5-year period of coursework and mentored research in the areas of sophisticated longitudinal data analytic techniques and data collection so that she develops the expertise necessary to pursue an independent research career examining associations between internalizing disorders and substance use and disorders. The first training goal focuses on gaining expertise in a number of longitudinal statistical analysis techniques (e.g., growth curve modeling, latent transition analysis) and will be achieved through a combination of coursework and mentored research. These techniques will initially be applied to two longitudinal archival data sets, the Minnesota Twin Family Study and the Pittsburgh Youth Study (Years 1-4). The second training goal involves mentored data collection; frequent assessments of a sample of disadvantaged youth in Camden, New Jersey will be conducted (Years 4-5). In Year 5 of this career development award, the PI will apply her statistical expertise to her own longitudinal data from the Camden study and apply for an R01 grant to expand her Camden Longitudinal Study and examine emerging questions relating to psychopathology and substance use problems. The proposed research examines longitudinal associations between internalizing disorders (depression, generalized anxiety, and social anxiety) and substance use and disorders (abuse and dependence). Direct examinations of two important potential moderators of these associations-gender and antisocial behavior- will be included and are viewed as crucial to developing an accurate understanding of longitudinal pathways between and among these problems. By using sophisticated longitudinal statistical techniques that are both variable-centered and person-centered and by using three complementary data sets, the research conducted during the 5-year period of this career development award will result in a comprehensive model of the longitudinal associations between internalizing disorders and substance use and disorders and will enable the PI to proceed onto an independent, highly productive program of research that propels the field to a deeper and more thorough understanding of the associations between psychopathology and substance use problems over time. This research is important to public health because a clear understanding of the associations between mental health and substance use problems will lead to more effective and targeted prevention and intervention efforts, thereby reducing the burden of mental illness and substance use problems on society.