Longtudinal Relations Between Internalizing Disorders and Substance Use Problems

内化障碍与药物使用问题之间的纵向关系

• 批准号: 7888317
• 负责人: NAOMI R MARMORSTEIN
• 金额: $ 16.85万
• 依托单位: RUTGERS THE STATE UNIV OF NJ CAMDEN
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7888317
• 关键词: Adolescent; Alcohol or Other Drugs use; Alcohols; Anxiety; Area; Behavior; Behavior Disorders; Caffeine; Comorbidity; Conflict (Psychology); Data; Data Collection; Data Set; Dependence; Disadvantaged; Disease; Drug usage; Family Study; Female; Gender; Goals; Grant; Growth; Illicit Drugs; K-Series Research Career Programs; Lead; Longitudinal Studies; Mental Depression; Mental Health; Mental disorders; Mentors; Minnesota; Modeling; Nature; New Jersey; Nicotine; Nicotine Dependence; Pathway interactions; Pharmaceutical Preparations; Preventive Intervention; Psychopathology; Public Health; Research; Sampling; Smoke; Societies; Substance Use Disorder; Symptoms; Techniques; Time; Training; Twin Multiple Birth; Youth; alcohol measurement; anti social; career; depressive symptoms; drug development; early adolescence; male; person centered; programs; social; young adult

DESCRIPTION (provided by applicant): The goal of this Research Career Development Award (K01) is to provide the PI with a 5-year period of coursework and mentored research in the areas of sophisticated longitudinal data analytic techniques and data collection so that she develops the expertise necessary to pursue an independent research career examining associations between internalizing disorders and substance use and disorders. The first training goal focuses on gaining expertise in a number of longitudinal statistical analysis techniques (e.g., growth curve modeling, latent transition analysis) and will be achieved through a combination of coursework and mentored research. These techniques will initially be applied to two longitudinal archival data sets, the Minnesota Twin Family Study and the Pittsburgh Youth Study (Years 1-4). The second training goal involves mentored data collection; frequent assessments of a sample of disadvantaged youth in Camden, New Jersey will be conducted (Years 4-5). In Year 5 of this career development award, the PI will apply her statistical expertise to her own longitudinal data from the Camden study and apply for an R01 grant to expand her Camden Longitudinal Study and examine emerging questions relating to psychopathology and substance use problems. The proposed research examines longitudinal associations between internalizing disorders (depression, generalized anxiety, and social anxiety) and substance use and disorders (abuse and dependence). Direct examinations of two important potential moderators of these associations-gender and antisocial behavior- will be included and are viewed as crucial to developing an accurate understanding of longitudinal pathways between and among these problems. By using sophisticated longitudinal statistical techniques that are both variable-centered and person-centered and by using three complementary data sets, the research conducted during the 5-year period of this career development award will result in a comprehensive model of the longitudinal associations between internalizing disorders and substance use and disorders and will enable the PI to proceed onto an independent, highly productive program of research that propels the field to a deeper and more thorough understanding of the associations between psychopathology and substance use problems over time. This research is important to public health because a clear understanding of the associations between mental health and substance use problems will lead to more effective and targeted prevention and intervention efforts, thereby reducing the burden of mental illness and substance use problems on society.

描述(由申请者提供)：这个研究职业发展奖(K01)的目标是在复杂的纵向数据分析技术和数据收集领域为PI提供为期5年的课程工作和指导研究，以便她发展必要的专业知识，以追求独立的研究职业生涯，检查内在化障碍与物质使用和障碍之间的联系。第一个培训目标侧重于获得一些纵向统计分析技术方面的专业知识(例如，增长曲线建模、潜在转变分析)，并将通过课程作业和指导研究相结合来实现。这些技术最初将应用于两个纵向档案数据集，明尼苏达州双胞胎家庭研究和匹兹堡青年研究(1-4岁)。第二个培训目标涉及有指导的数据收集；将经常对新泽西州卡姆登的弱势青年样本进行评估(4-5年级)。在这个职业发展奖的第五年，PI将把她的统计专业知识应用于她自己从卡姆登研究中获得的纵向数据，并申请R01拨款，以扩大她的卡姆登纵向研究，并审查与精神病理学和药物使用问题有关的新问题。 这项拟议的研究考察了内在性障碍(抑郁、广泛性焦虑和社交焦虑)与物质使用和障碍(滥用和依赖)之间的纵向联系。对这些联系的两个重要的潜在调解人--性别和反社会行为--的直接检查将被包括在内，并被视为对这些问题之间的纵向路径的准确理解至关重要。通过使用复杂的纵向统计技术，既以变量为中心，又以人为中心，并使用三个互补的数据集，在本职业发展奖的5年期间进行的研究将产生内在化障碍与物质使用和障碍之间的纵向联系的综合模型，并将使PI能够继续进行独立的、高生产力的研究计划，推动该领域随着时间的推移对精神病理学和物质使用问题之间的联系有更深入和更彻底的了解。 这项研究对公共卫生很重要，因为清楚了解精神健康和药物使用问题之间的联系将导致更有效和有针对性的预防和干预工作，从而减轻精神疾病和药物使用问题对社会的负担。