Health Promotion for Positives: A Randomized Trial with HIV Positive Black Men

积极健康促进：艾滋病毒阳性黑人男性的随机试验

• 批准号: 8600632
• 负责人: JOHN BARTON JEMMOTT
• 金额: $ 39.95万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-21 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8600632
• 关键词: AIDS prevention; AIDS-Related Opportunistic Infections; Adherence; Affect; African American; Age; Aging; Anti-Retroviral Agents; Applications Grants; Attention; Behavior; Behavioral; Blood Pressure; Body mass index; Budgets; Cardiovascular Diseases; Centers for Disease Control and Prevention (U.S.); Chronic; Chronic Disease; Colon Carcinoma; Comorbidity; Complement; Computer Assisted; Control Groups; Couples; Data; Diabetes Mellitus; Diet; Evidence based intervention; Expectancy; Future; General Population; Guidelines; HIV; HIV Infections; HIV Seropositivity; Health; Health Promotion; Health behavior; Highly Active Antiretroviral Therapy; Hour; Hypertension; Individual; Intervention; Interview; Kidney Diseases; Life; Link; Long-Term Effects; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mediating; Mediator of activation protein; Medical Records; Morbidity - disease rate; Outcome; Participant; Patient Self-Report; Persons; Physical Fitness; Physical activity; Physiological; Prevention; Prostate; Randomized; Randomized Controlled Trials; Research; Risk; Screening for Prostate Cancer; Self Efficacy; Testing; Time; Treatment Efficacy; United States; Vulnerable Populations; Waist-Hip Ratio; Walking; base; behavior change; comparative efficacy; design; effective therapy; efficacy testing; empowered; experience; fitness; fruits and vegetables; health disparity; high risk; innovation; interest; man; men; mortality; post intervention; primary outcome; randomized trial; response; screening; sex; social cognitive theory; successful intervention; theories; waist circumference

PROJECT SUMMARY: This application is in response to RFA-MD-12-001, "NIMHD Health Disparities Research (R01)." African American men who are infected with HIV are living longer and are being impacted by the same chronic diseases that affect the general population of African American men over 40. To be sure, African American men, in general, have disproportionately high rates of cardiovascular disease, hypertension, diabetes, kidney disease, and cancer, particularly prostate and colon cancer. However, HIV infection is associated with an increased risk for co-morbidity from chronic diseases. This increased risk is heightened by HIV infection, but also its treatment with certain agents used in highly active antiretroviral therapy (HAART) combinations. Many of these chronic illnesses have behavioral components-risk is influenced by what people do and don't do, their diet, and the amount of physical activity they get. Although the high risk for multiple behavior-linked chronic diseases among HIV-positive individuals has been recognized, there is a lack of evidence-based intervention specifically tailored to their needs. Hence, the broad objective is to reduce the risk of chronic diseases among HIV positive African American men. The Specific Aims are to test the efficacy of a theory- based, contextually appropriate health promotion intervention in inducing positive changes in behaviors linked to risk of chronic diseases among HIV positive African American men age 40 years or older and to identify the theoretical variables that mediate its efficacy. The study will utilize a randomized controlled trial. The participants will be 384 African American HIV positive men age 40 or older who are receiving HAART for HIV. The men will be randomized to a theory-based contextually appropriate health promotion intervention that involves three, 3-hour weekly intervention sessions or an attention-control group. The health promotion intervention will be an adaptation of an intervention based on social cognitive theory integrated with formative research and found to be efficacious in increasing adherence to 5-a-Day diet and physical activity guidelines and prostate cancer screening guidelines in the applicants' preliminary studies. Data will be collected at baseline, immediately post, 3, 6 and 12 months post intervention, which will permit assessment of the short- term and long-term effects of the intervention and whether the intervention's efficacy varies over time. Audio computer-assisted self-interviewing will be used to assess self-reported adherence to physical activity guidelines, 5-a-Day fruit and vegetable guidelines, prostate screening guidelines, and colon cancer screening guidelines and theoretical mediators of behavior change. Objective outcomes will include health-related fitness (6-minute walk test, 1-minute push-up test, 1-minute sit-up test, sit-and-reach test), physiological variables (blood pressure, body mass index, waist circumference, and waist-hip ratio), and prostate and colon cancer screening based on medical record review.

项目概要： 本申请是对RFA-MD-12-001“NIMHD健康差异研究（R 01）”的回应。“非洲人 感染艾滋病毒的美国男性寿命更长，并受到同样的慢性疾病的影响。 影响40岁以上非裔美国人的疾病。 当然，非裔美国人 一般来说，男性患心血管疾病、高血压、糖尿病、肾病 疾病和癌症，特别是前列腺癌和结肠癌。 然而，艾滋病毒感染与 增加慢性病合并症的风险。 这种增加的风险因艾滋病毒感染而加剧，但 也可以使用某些用于高效抗逆转录病毒疗法（HAART）组合的药物进行治疗。 许多 这些慢性病都有行为因素--风险受到人们做什么和不做什么的影响， 他们的饮食和他们的体育活动量。 虽然与多种行为相关的高风险 艾滋病毒阳性者中的慢性病已得到承认，但缺乏循证医学 专门针对他们的需求进行干预。因此，广泛的目标是减少慢性疾病的风险。 艾滋病毒阳性的非裔美国人的疾病。 具体目标是检验一种理论的有效性- 基于环境的适当健康促进干预，以诱导相关行为的积极变化 40岁或40岁以上的艾滋病毒阳性非洲裔美国男性患慢性病的风险，并确定 调节其功效的理论变量。 本研究将采用随机对照试验。 的 参与者将是384名年龄在40岁或40岁以上的非洲裔美国人HIV阳性男性，他们正在接受HAART治疗HIV。 这些人将被随机分配到一个基于理论的、与环境相适应的健康促进干预组， 包括每周3小时的干预会议或注意力控制小组。 健康促进 干预将是基于社会认知理论的干预的适应， 研究发现，在提高对每日5次饮食和身体活动指南的依从性方面是有效的 和前列腺癌筛查指南。 数据将在 基线、干预后即刻、干预后3个月、6个月和12个月，这将允许评估短期- 干预措施的长期和长期效果以及干预措施的效力是否随时间而变化。 音频 将使用计算机辅助自我访谈来评估自我报告的身体活动依从性 指南，每天5份水果和蔬菜指南，前列腺筛查指南和结肠癌筛查 行为改变的指导方针和理论调解人。 客观结果将包括健康相关的健身 （6分钟步行试验、1分钟俯卧撑试验、1分钟仰卧起坐试验、坐位体前屈试验）、生理变量 （血压、体重指数、腰围和腰臀比），以及前列腺癌和结肠癌 根据病历审查进行筛查。