Maternal gestational diabetes in Hispanic youth: obesity and insulin resistance

西班牙裔青少年的孕产妇妊娠糖尿病：肥胖和胰岛素抵抗

• 批准号: 8662761
• 负责人: Kathleen Alanna Page
• 金额: $ 15.49万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-02 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8662761
• 关键词: Adolescent; Adult; Age; Animal Model; Beta Cell; Birth; Body fat; Body mass index; Brain; California; Cell physiology; Child; Childhood; Clinical; Clinical Investigator; Clinical Research; Communities; Deposition; Development; Development Plans; Diabetes Mellitus; Diabetic mother; Disease; Early treatment; Education; Endocrine; Endocrinology; Environment; Epidemic; Ethnic Origin; Exposure to; Fasting; Fatty acid glycerol esters; Fellowship; Fetal Tissues; Financial compensation; Fostering; Functional disorder; Gender; Gene Expression; Genes; Genetic; Gestational Diabetes; Goals; Hispanic Americans; Hispanics; Human; Hypothalamic structure; Inflammatory; Institutes; Institution; Insulin Resistance; Internal Medicine; Investigation; Islets of Langerhans; Laboratories; Lead; Lipids; Liver; Magnetic Resonance Imaging; Master' s Degree; Measures; Mediating; Mentors; Metabolic; Metabolism; Mothers; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Obesity; Pathogenesis; Pathway interactions; Pima Indian; Population; Population Study; Positioning Attribute; Pregnancy in Diabetics; Prevalence; Prevention; Regulation; Research; Research Proposals; Research Training; Residencies; Resources; Risk; Risk Factors; Role; Sampling; Seminal; Staging; Testing; Training; Translational Research; United States National Institutes of Health; Universities; Visceral; Work; Youth; abdominal fat; adipokines; authority; base; blood glucose regulation; career; career development; cytokine; design; diabetes risk; diabetic; glucose metabolism; high risk; imprint; improved; in utero; indexing; inflammatory marker; insulin sensitivity; interest; intravenous glucose tolerance test; maternal diabetes; medical schools; obesity in children; obesity risk; offspring; patient oriented research; patient population; prevent; programs; research and development; subcutaneous; success; translational study; treatment strategy; type I diabetic; young adult

DESCRIPTION (provided by applicant): The goal of this proposal is to foster the scientific development of Kathleen Page in order for her to become an independent clinical investigator. Her long-term goal is to develop an independent career as a clinical investigator in the field of diabetes and metabolism. She joined the Endocrine Division at the University of Southern California Keck School of Medicine last year after completing her internal medicine residency and endocrine fellowship training at the Yale School of Medicine. During her endocrinology fellowship, she initiated her research career in the laboratory of Dr. Robert Sherwin, a world leader in translational studies on the role of the brain in the regulation of glucose metabolism. With her move to USC, she is now presented with the unique opportunity of working with Thomas Buchanan, one of the world's leading authorities in type 2 diabetes, serving as her primary mentor for this work. Dr. Buchanan and his colleagues have performed seminal studies in the field of gestational diabetes which is most relevant to Dr. Page's current research proposal that is designed to study the risk of developing obesity and type 2 diabetes in the offspring of mothers with gestational diabetes. The central theme of her research proposal is directed at determining the potential importance to the intrauterine exposure to gestational diabetes to the subsequent development of obesity and/or type 2 diabetes in childhood or later as an adult. This study not only represents an intriguing research question but also provides a very plausible explanation for our recent epidemic of type 2 diabetes occurring in children and young adults. This problem is especially prevalent in the Hispanic-American community, which will serve as the focus of her study population. These studies will not only provide important information about mechanisms and the underlying risk for developing type 2 diabetes but may also lead to development of better designed strategies to prevent this disease. USC is an institution ideally situated for her interest in pursuing translational human based diabetes and obesity research. She has selected a mentoring team that includes experts in the fields of gestational diabetes (Dr. Thomas Buchanan), pediatric obesity and diabetes (Dr. Michael Goran), and pathophysiology of glucose regulation (Dr. Richard Bergman). She will also benefit from the support and resources provided by the NIH supported Clinical Translational Science Institute at USC. As part of her career development plan she will pursue the USC Masters in Clinical and Biomedical Investigation program. This program combines formal didactic and co-curricular education with mentored practical research leading to the Masters Degree. Completion of this program with provide Dr. Page with the formal training in clinical and translational research that she requires for success. The research and career development plan outlined in this proposal will prepare Dr. Page for an independent career in clinical translational research dedicated to improving our understanding of the pathogenesis of obesity and type 2 diabetes.

描述（由申请人提供）：本提案的目标是促进Kathleen Page的科学发展，以便她成为独立的临床研究者。她的长期目标是发展一个独立的职业生涯作为糖尿病和代谢领域的临床研究者。去年，她在耶鲁医学院完成了内科住院医师和内分泌奖学金培训后，加入了南加州凯克医学院的内分泌科。在她的内分泌奖学金期间，她在Robert Sherwin博士的实验室开始了她的研究生涯，Robert Sherwin博士是关于大脑在葡萄糖代谢调节中的作用的转化研究的世界领导者。随着她搬到南加州大学，她现在提出了与托马斯布坎南，在2型糖尿病的世界领先的权威之一，作为她的主要导师这项工作的独特机会。Buchanan博士和他的同事们在妊娠糖尿病领域进行了开创性的研究，这与Page博士目前的研究计划最相关，该计划旨在研究患有妊娠糖尿病的母亲的后代患肥胖症和2型糖尿病的风险。她的研究建议的中心主题是针对确定潜在的重要性宫内暴露于妊娠期糖尿病的肥胖和/或2型糖尿病在儿童期或以后的成年人的后续发展。这项研究不仅代表了一个有趣的研究问题，而且为我们最近在儿童和年轻人中流行的2型糖尿病提供了一个非常合理的解释。这个问题在西班牙裔美国人社区尤其普遍，这将成为她研究人群的重点。这些研究不仅将提供有关发生2型糖尿病的机制和潜在风险的重要信息，而且还可能导致制定更好的预防这种疾病的策略。南加州大学是一个理想的机构，她在追求翻译人类为基础的糖尿病和肥胖研究的兴趣。她选择了一个指导团队，其中包括妊娠糖尿病（托马斯布坎南博士），儿童肥胖和糖尿病（迈克尔戈兰博士），和葡萄糖调节的病理生理学（理查德伯格曼博士）领域的专家。她还将受益于美国国立卫生研究院支持的南加州大学临床转化科学研究所提供的支持和资源。作为她职业发展计划的一部分，她将攻读南加州大学临床和生物医学研究硕士学位。该计划将正式的教学和课外教育与指导实践研究相结合，从而获得硕士学位。完成该计划为Page博士提供了她成功所需的临床和转化研究方面的正式培训。本提案中概述的研究和职业发展计划将为Page博士在临床转化研究中的独立职业生涯做好准备，致力于提高我们对肥胖和2型糖尿病发病机制的理解。