Maternal gestational diabetes in Hispanic youth: obesity and insulin resistance

描述（由申请人提供）：本提案的目标是促进Kathleen Page的科学发展，使她成为一名独立的临床研究者。她的长期目标是在糖尿病和代谢领域成为一名独立的临床研究者。去年，她在完成了耶鲁大学医学院的内科住院医师和内分泌奖学金培训后，加入了南加州大学凯克医学院的内分泌部门。在担任内分泌学研究员期间，她在Robert Sherwin博士的实验室开始了她的研究生涯，Robert Sherwin博士是大脑在葡萄糖代谢调节中的作用转化研究的世界领导者。随着她搬到南加州大学，她现在有了一个独特的机会，与世界领先的2型糖尿病权威之一托马斯·布坎南（Thomas Buchanan）一起工作，他是她这项工作的主要导师。布坎南博士和他的同事们在妊娠糖尿病领域进行了开创性的研究，这与佩奇博士目前的研究计划最相关，该计划旨在研究患有妊娠糖尿病的母亲的后代患肥胖症和2型糖尿病的风险。她的研究计划的中心主题是确定宫内暴露于妊娠期糖尿病对儿童或成年后肥胖和/或2型糖尿病后续发展的潜在重要性。这项研究不仅代表了一个有趣的研究问题，而且为我们最近在儿童和年轻人中流行的2型糖尿病提供了一个非常合理的解释。这个问题在西班牙裔美国人社区尤其普遍，这将成为她研究人群的重点。这些研究不仅将提供有关2型糖尿病发病机制和潜在风险的重要信息，而且还可能导致开发出更好的设计策略来预防这种疾病。南加州大学是一个理想的机构，她有兴趣追求转化人类糖尿病和肥胖研究。她选择了包括妊娠糖尿病（Thomas Buchanan博士）、儿童肥胖和糖尿病（Michael Goran博士）、葡萄糖调节病理生理学（Richard Bergman博士）等领域的专家组成的指导小组。她还将受益于美国国立卫生研究院支持的南加州大学临床转化科学研究所提供的支持和资源。作为她职业发展计划的一部分，她将攻读南加州大学临床和生物医学研究硕士学位。该课程将正式的教学和课外教育与指导的实践研究相结合，最终获得硕士学位。该项目的完成将为佩奇博士提供临床和转化研究方面的正式培训，这是她成功所需的。本提案中概述的研究和职业发展计划将为Page博士在临床转化研究方面的独立职业生涯做好准备，致力于提高我们对肥胖和2型糖尿病发病机制的理解。

DESCRIPTION (provided by applicant): The goal of this proposal is to foster the scientific development of Kathleen Page in order for her to become an independent clinical investigator. Her long-term goal is to develop an independent career as a clinical investigator in the field of diabetes and metabolism. She joined the Endocrine Division at the University of Southern California Keck School of Medicine last year after completing her internal medicine residency and endocrine fellowship training at the Yale School of Medicine. During her endocrinology fellowship, she initiated her research career in the laboratory of Dr. Robert Sherwin, a world leader in translational studies on the role of the brain in the regulation of glucose metabolism. With her move to USC, she is now presented with the unique opportunity of working with Thomas Buchanan, one of the world's leading authorities in type 2 diabetes, serving as her primary mentor for this work. Dr. Buchanan and his colleagues have performed seminal studies in the field of gestational diabetes which is most relevant to Dr. Page's current research proposal that is designed to study the risk of developing obesity and type 2 diabetes in the offspring of mothers with gestational diabetes. The central theme of her research proposal is directed at determining the potential importance to the intrauterine exposure to gestational diabetes to the subsequent development of obesity and/or type 2 diabetes in childhood or later as an adult. This study not only represents an intriguing research question but also provides a very plausible explanation for our recent epidemic of type 2 diabetes occurring in children and young adults. This problem is especially prevalent in the Hispanic-American community, which will serve as the focus of her study population. These studies will not only provide important information about mechanisms and the underlying risk for developing type 2 diabetes but may also lead to development of better designed strategies to prevent this disease. USC is an institution ideally situated for her interest in pursuing translational human based diabetes and obesity research. She has selected a mentoring team that includes experts in the fields of gestational diabetes (Dr. Thomas Buchanan), pediatric obesity and diabetes (Dr. Michael Goran), and pathophysiology of glucose regulation (Dr. Richard Bergman). She will also benefit from the support and resources provided by the NIH supported Clinical Translational Science Institute at USC. As part of her career development plan she will pursue the USC Masters in Clinical and Biomedical Investigation program. This program combines formal didactic and co-curricular education with mentored practical research leading to the Masters Degree. Completion of this program with provide Dr. Page with the formal training in clinical and translational research that she requires for success. The research and career development plan outlined in this proposal will prepare Dr. Page for an independent career in clinical translational research dedicated to improving our understanding of the pathogenesis of obesity and type 2 diabetes.