Project 3: A Genomic Approach to Improved Diagnosis and Treatment of Neuroendocrine Tumors

项目 3：改进神经内分泌肿瘤诊断和治疗的基因组方法

• 批准号: 8850627
• 负责人: JAMES R HOWE
• 金额: $ 28.75万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8850627
• 关键词: Accounting; Cell Surface Receptors; Characteristics; Clinical; DNA; Data; Detection; Development; Diagnosis; Diagnostic Imaging; Distant Metastasis; Excision; Family; Future; Gastrointestinal Neoplasms; Gene Expression; Gene Expression Profile; Gene Targeting; Genes; Genetic; Genomic approach; Germ-Line Mutation; Goals; Human; Image; Incidence; Knowledge; Lead; Ligands; Malignant - descriptor; Malignant Neoplasms; Medical Imaging; Metastatic Neoplasm to the Liver; Modality; Molecular; Molecular Profiling; Mutate; Mutation; Neoplasm Metastasis; Neuroendocrine Tumors; Normal tissue morphology; Operative Surgical Procedures; Outcome; Pancreas; Pathogenesis; Pathway interactions; Patients; Play; Primary Neoplasm; Proteins; RNA; Recording of previous events; Relative (related person); Research; Role; Site; Small Intestines; Somatic Mutation; Specialized Program of Research Excellence; Staging; Survival Rate; Susceptibility Gene; Symptoms; Testing; Therapeutic; Translating; Work; base; effective therapy; exome; exome sequencing; improved; innovation; insight; novel; novel diagnostics; novel therapeutics; protein expression; receptor; research clinical testing; targeted treatment; treatment site; treatment strategy; tumor

The incidence of Neuroendocrine Tumors (NETs) has increased five-fold over the last three decades, and many patients do not develop symptoms until the tumors have metastasized. Although patients with these tumors may have prolonged survival despite advanced stage, further understanding of the molecular biologic basis of NETs holds the promise for improved diagnosis, imaging, and therapy. We hypothesize that analyzing the gene expression profiles of these tumors and their exomes will allow us to identify important genes that will facilitate clinical advances for patients with these tumors. This contribution will be significant because it will allow us to determine the tumor site of origin in patients presenting with liver metastases and unknown primaries, which will lead to more directed surgical exploration and resection; and knowledge of cell surface receptors or other genes significantly over-expressed in NETs relative to normal tissues will facilitate the development of new targets for detection, imaging, and medical management. Novel targets for therapy will also be suggested by the identification of frequently mutated or deleted genes in these tumors or the germline of patients with familial NETs.

神经内分泌肿瘤（NETs）的发病率在过去三十年中增加了五倍