Center for Pediatric Research

描述(由申请者提供)：本申请的主要目标是通过建立儿科研究中心，为具有转译研究项目的基础科学家建立基础，研究儿童疾病的发育机制。许多儿科疾病的起源是与细胞增殖、形态发生、迁移、分化和程序性死亡过程有关的发育编程改变。这些发育过程是儿科疾病的根源，并通过遗传障碍、异常的胎儿编程、改变的生长发育和环境压力而中断。我们的多学科中心将遗传学、生化、细胞和分子方法应用于几种模式生物，以表征发育过程中与儿科疾病和紊乱有关的变化。来自五位有潜力成为国家一级有竞争力的科学家的杰出早期研究人员的项目 已选择用于此应用程序。中心的成功将通过以下目标实现：1)为研究与儿科疾病机制相关的发展过程的基础科学家创造一个支持性的培训和指导环境；2)利用将加强儿科研究的新的和现有的资源；3)加强沟通机制，以促进和启动临床和转化性研究项目；4)扩大儿科疾病和发育生物学方面的培训和学习机会；以及5)评估中心的成功。通过这些目标，儿科研究中心将通过促进科学家和医生的合作环境，在基础和转化性研究方面奠定坚实的基础。由于我们机构对儿童医学的坚定承诺，我们建议该中心将加强南达科他州的儿科研究工作。

DESCRIPTION (provided by applicant): The primary goal of this application is to establish a foundation of basic scientists with translational research projects studying developmental mechanisms underlying children's disease by establishing the Center for Pediatric Research. The origin of many pediatric diseases is from altered developmental programming related to the processes of cell proliferation, morphogenesis, migration, differentiation, and programmed death. These developmental processes are at the root of pediatric disease and are disrupted through genetic disorders, aberrant fetal programming, altered growth & development, and environmental pressures. Our multidisciplinary Center applies genetic, biochemical, cell, and molecular approaches across several model organisms to characterize alterations during development as they pertain to pediatric diseases and disorders. Projects from five outstanding early-stage investigators with the potential to become competitive scientists at the national level have been selected for this application. Center success will be achieved through the following Aims: 1) create a supportive environment for the training and mentorship of basic scientists studying developmental processes related to pediatric disease mechanisms; 2) utilize new and existing resources that will enhance pediatric research; 3) enhance communication mechanisms to promote and initiate clinical and translational research projects; 4) expand training and learning opportunities in the biology of pediatric disease and development; and 5) evaluate success of the Center. Through these Aims, the Center for Pediatric Research will develop a strong foundation in basic and translational research by fostering a collaborative environment for scientists and physicians. Strengthened by our institution's strong commitment to children's medicine, we propose that the Center will enhance pediatric research efforts in South Dakota.