Center for Pediatric Research

描述（由申请人提供）：本申请的主要目标是通过建立儿科研究中心，为基础科学家建立一个研究儿童疾病发展机制的转化研究项目的基础。许多儿科疾病的起源是与细胞增殖、形态发生、迁移、分化和程序性死亡过程相关的发育程序改变。这些发育过程是儿科疾病的根源，并因遗传疾病、异常的胎儿规划、改变的生长发育和环境压力而中断。我们的多学科中心应用遗传学、生物化学、细胞和分子方法，研究几种模式生物在发育过程中的变化，因为它们与儿科疾病和失调有关。五名有潜力成为国家级有竞争力科学家的杰出早期研究人员的项目

DESCRIPTION (provided by applicant): The primary goal of this application is to establish a foundation of basic scientists with translational research projects studying developmental mechanisms underlying children's disease by establishing the Center for Pediatric Research. The origin of many pediatric diseases is from altered developmental programming related to the processes of cell proliferation, morphogenesis, migration, differentiation, and programmed death. These developmental processes are at the root of pediatric disease and are disrupted through genetic disorders, aberrant fetal programming, altered growth & development, and environmental pressures. Our multidisciplinary Center applies genetic, biochemical, cell, and molecular approaches across several model organisms to characterize alterations during development as they pertain to pediatric diseases and disorders. Projects from five outstanding early-stage investigators with the potential to become competitive scientists at the national level have been selected for this application. Center success will be achieved through the following Aims: 1) create a supportive environment for the training and mentorship of basic scientists studying developmental processes related to pediatric disease mechanisms; 2) utilize new and existing resources that will enhance pediatric research; 3) enhance communication mechanisms to promote and initiate clinical and translational research projects; 4) expand training and learning opportunities in the biology of pediatric disease and development; and 5) evaluate success of the Center. Through these Aims, the Center for Pediatric Research will develop a strong foundation in basic and translational research by fostering a collaborative environment for scientists and physicians. Strengthened by our institution's strong commitment to children's medicine, we propose that the Center will enhance pediatric research efforts in South Dakota.