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Center for Pediatric Research

儿科研究中心

基本信息

批准号：
10004058
负责人：
DAVID A. PEARCE
金额：
$ 242.18万
依托单位：
SANFORD RESEARCH/USD
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10004058
关键词：
Advisory Committees Animal Model Applications Grants Basic Science Biochemical Biochemistry Bioinformatics Caring Cell Proliferation Cell physiology Cells Cellular biology Centers of Research Excellence Cessation of life Child Child Development Child Health Childhood Clinic Clinical Clinical Research Communities Complement Core Facility Data Development Developmental Biology Developmental Process Diagnosis Disease Effectiveness Environment Evaluation Fostering Foundations Funding Genetic Genetic Diseases Goals Growth and Development function Health Healthcare Systems Human Biology Human Development Image Institution Interdisciplinary Study K-12 student Leadership Learning Medical Students Medicine Mentors Mentorship Mind Modeling Molecular Molecular Biology Morphogenesis Pediatric Hospitals Pediatric Research Phase Physicians Plant Roots Postdoctoral Fellow Regulation Research Research Activity Research Personnel Research Project Grants Research Training Resources Role Rural Science Scientist Sioux Falls South Dakota Technical Expertise Training Translational Research United States United States National Institutes of Health base collaborative environment data submission experience fetal programming functional genomics graduate student human disease improved innovation learning community medical specialties member migration multidisciplinary northern plains outreach pressure recruit skills success supportive environment training opportunity translational study undergraduate student

项目摘要

PROJECT SUMMARY The primary goal of this application is to establish a foundation of basic scientists with translational research projects studying developmental mechanisms underlying children's disease by establishing the Center for Pediatric Research. The origin of many pediatric diseases is from altered developmental programming related to the processes of cell proliferation, morphogenesis, migration, differentiation, and programmed death. These developmental processes are at the root of pediatric disease and are disrupted through genetic disorders, aberrant fetal programming, altered growth & development, and environmental pressures. Our multidisciplinary Center applies genetic, biochemical, cell, and molecular approaches across several model organisms to characterize alterations during development as they pertain to pediatric diseases and disorders. For phase II we will continue to build upon the success of phase I efforts to create a critical mass of independently funded investigators within the Center for Pediatric Research by refining our focus to support and mentor junior investigators whose research investigates how key regulators of cellular pliancy contribute to the developmental origin of pediatric disorders. Center success will be achieved through the following Aims: 1) create a supportive environment for the training and mentorship of scientists studying how regulation of cell pliancy contributes to pediatric diseases; 2) utilize and enhance existing resources that will enable pediatric research; 3) expand training and learning opportunities in developmental biology and pediatric disease; and 4) evaluate success of the Center. Through these Aims, the Center for Pediatric Research will develop a strong foundation in basic and translational research by fostering a collaborative environment for scientists and physicians. Strengthened by our institution's strong commitment to children's medicine, we propose that the Center will continue to enhance pediatric research efforts in South Dakota.

项目总结