Center for Pediatric Research

项目摘要 这项申请的主要目标是建立一个基础科学家与转化研究 通过建立儿童疾病研究中心， 儿科研究。许多儿科疾病的起源是从改变发育编程有关 细胞增殖、形态发生、迁移、分化和程序性死亡的过程。这些 发育过程是儿科疾病的根源，并因遗传疾病而中断， 异常的胎儿编程、改变的生长和发育以及环境压力。我们的多学科 中心应用遗传，生物化学，细胞和分子方法在几个模式生物， 表征发育过程中的变化，因为它们与儿科疾病和病症有关。第二阶段 我们将继续在第一阶段成功的基础上，建立一个独立资助的关键质量 研究人员在儿科研究中心通过完善我们的重点，以支持和指导初级 他们的研究调查了细胞柔顺性的关键调节因子如何促进细胞的生长。 儿科疾病的发育起源。中心的成功将通过以下目标实现：1） 创造一个支持性的环境，培训和指导研究细胞调节如何 顺应性有助于儿科疾病; 2）利用和加强现有资源，使儿科疾病 研究; 3）扩大发育生物学和儿科疾病的培训和学习机会;以及4） 评估中心的成功。通过这些目标，儿科研究中心将发展一个强大的 通过为科学家营造合作环境，为基础和转化研究奠定基础， 医生由于我们机构对儿童医学的坚定承诺，我们建议， 中心将继续加强在南达科他州的儿科研究工作。

PROJECT SUMMARY The primary goal of this application is to establish a foundation of basic scientists with translational research projects studying developmental mechanisms underlying children's disease by establishing the Center for Pediatric Research. The origin of many pediatric diseases is from altered developmental programming related to the processes of cell proliferation, morphogenesis, migration, differentiation, and programmed death. These developmental processes are at the root of pediatric disease and are disrupted through genetic disorders, aberrant fetal programming, altered growth & development, and environmental pressures. Our multidisciplinary Center applies genetic, biochemical, cell, and molecular approaches across several model organisms to characterize alterations during development as they pertain to pediatric diseases and disorders. For phase II we will continue to build upon the success of phase I efforts to create a critical mass of independently funded investigators within the Center for Pediatric Research by refining our focus to support and mentor junior investigators whose research investigates how key regulators of cellular pliancy contribute to the developmental origin of pediatric disorders. Center success will be achieved through the following Aims: 1) create a supportive environment for the training and mentorship of scientists studying how regulation of cell pliancy contributes to pediatric diseases; 2) utilize and enhance existing resources that will enable pediatric research; 3) expand training and learning opportunities in developmental biology and pediatric disease; and 4) evaluate success of the Center. Through these Aims, the Center for Pediatric Research will develop a strong foundation in basic and translational research by fostering a collaborative environment for scientists and physicians. Strengthened by our institution's strong commitment to children's medicine, we propose that the Center will continue to enhance pediatric research efforts in South Dakota.