Specialized Cancer Center Support Grant

描述（由申请人提供）：加州大学圣地亚哥分校（UCSD）摩尔斯癌症中心（MCC）拥有丰富的历史，作为一个矩阵，nci指定的综合癌症中心，现在有来自加州大学圣地亚哥分校28个部门的239名成员。经同行评审的世纪挑战集团资金为1.183亿美元（直接费用），其中3320万美元来自NCI。来自非同行审查来源的额外1 560万美元使直接费用供资总额达到1.339亿美元。在资助期内，我们发表了4000多篇关于癌症的论文（20%在项目内部或项目内部发表；10%在影响因子为15的期刊上发表）。在美国最大的生命科学集群圣地亚哥/拉霍亚，MCC周围有其他几家主要的生命科学研究机构和489家生物技术公司。MCC是该地区唯一一家nci指定的综合性癌症中心。世纪挑战集团利用这一优势，通过改变癌症预防、检测和护理（使命），并使个性化癌症医学成为现实（愿景），拯救生命。这是我们作为合作伙伴圣地亚哥州立大学（SDSU）的联盟中心的第一次续签申请，从而正式确立了中冶集团与圣地亚哥州立大学之间长期、富有成效的合作关系。按照设计，MCC大楼1)促进了该中心基础科学、临床科学和人口科学部门的医生和科学家之间的跨学科合作，2)将nci支持的广泛共享资源集中在一个公共的、可访问的站点上，3)作为圣地亚哥公共和私营部门转化癌症研究人员的学术-行业中心。绝大多数成员都在MCC大楼或加州大学圣地亚哥分校；其他人则在附近的拉霍亚学院。该应用报告了六个研究项目：癌症生物学和信号，癌症基因组和网络，血液恶性肿瘤，实体肿瘤治疗，癌症预防和减少癌症差异。我们还提出了七个共享资源：生物存储和组织技术，生物统计学，基因组学和生物信息学，显微镜，流式细胞术，转基因小鼠，饮食和体育活动。所有的项目和资源都反映了MCC的科学优势和目标。世纪挑战集团准备利用其卓越的基础科学和人口科学以及圣地亚哥范围内的合作（学术和私营部门）来开发创新的基于科学的癌症预防和治疗。这个应用程序总结了我们的投资、招聘、合作、组织变更、计划和实现这个目标的进展。

DESCRIPTION (provided by applicant): The UC San Diego (UCSD) Moores Cancer Center (MCC) has a rich history as a matrix, NCI-designated comprehensive cancer center, now with 239 members from 28 UCSD departments. Peer-reviewed MCC funding is $118.3 million (direct costs), of which $33.2 million is from the NCI. An additional $15.6 million from non-peer-reviewed sources results in total direct-cost funding of $133.9 million. We have published over 4000 cancer-focused papers in the funding period (20% inter- or intra-programmatic; 10% in journals with an impact factor >15). MCC is surrounded by several other major life-science research institutes and 489 biotechnology companies in San Diego/La Jolla, the 2"'' largest life-sciences cluster in the US. MCC is the only NCI-designated comprehensive cancer center in this region. MCC leverages this advantage to save lives by transforming cancer prevention, detection, and care (mission) and to make personalized cancer medicine a reality (vision). This is our first renewal application as a consortium center with partner San Diego State University (SDSU), thus formalizing long-standing, productive collaborations between MCC and SDSU. As designed, the MCC building 1) stimulates interdisciplinary collaboration between physicians and scientists in the Center's Divisions of Basic Science, Clinical Science, and Population Science, 2) assembles the extensive NCI-supported Shared Resources in a common, accessible site, and 3) acts as an academia-industry hub for translational cancer researchers within the public and private sectors of San Diego. The vast majority of members are in the MCC building or on the UCSD campus; others are in nearby La Jolla institutes. This application reports on six Research Programs: Cancer Biology and Signaling, Cancer Genomes and Networks, Hematologic Malignancies, Solid Tumor Therapeutics, Cancer Prevention, and Reducing Cancer Disparities. We also propose seven Shared Resources: Biorepository and Tissue Technology, Biostatistics, Genomics and Bioinformatics, Microscopy, Flow Cytometry, Transgenic Mouse, Diet and Physical Activity. All Programs and Resources reflect the scientific strengths and goals of the MCC. MCC is poised to leverage its exceptional basic and population sciences and San Diego-wide collaborations (academic and private-sector) in developing innovative science-based cancer prevention and treatment. This application summarizes our investments, recruitments, collaborations, organizational changes, plans, and progress toward this goal. CCSG funding advances the UCSD Moores Cancer Center mission to save lives by transforming cancer prevention, detection, and care, and vision to make personalized cancer medicine a reality. The Cancer Center places the highest priority on basic discovery and its translation (via leveraging San Diego's unique academia-industry environment) into major clinical advances that reduce the burden of cancer.