Core--Pathology/Genotyping

核心--病理学/基因分型

基本信息

  • 批准号:
    7102939
  • 负责人:
  • 金额:
    $ 42.26万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-04-01 至 2010-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The Southwest Oncology Group-led Prostate Cancer Prevention Trial (PCPT) was the first large-scale chemoprevention trial for prostate cancer (PCa). This trial, which enrolled >18,800 men, tested the ability of the 5-alpha-reductase inhibitor finasteride to reduce the period-prevalence of biopsy-proven PCa over a period of 7 years. A byproduct of the PCPT was the establishment of large specimen banks of biopsy tissue, prostatectomy specimens, serum, plasma, and white blood cells obtained from the participants at the end of the study and at various interim time points during the study. The overall aim of this revised application for Core C is to establish a Pathology and Genotyping Core in support of the molecular "Biology of the PCPT" Program Project. This core will provide expertise and resources in the following areas: 1) Archival Repository Management and Distribution of the various specimen banks established from the PCPT; 2) Histopathology, including diagnostic interpretation, microtomy, microscopy, laser-capture microdissection (LCM), immunohistochemistry (IHC), and computer-assisted image analysis; and 3) Genotyping and hormone analysis, overseeing the isolation of DNA, genotyping of samples and hormone analysis to be carried out by specialized central facilities. This revised proposal addresses all of the comments from the review of the original proposal and adds new preliminary data regarding reliability and quantification of IHC, quantification of DNA extracted from serum, and extraction and amplification of DNA from paraffin-embedded tissue sections using LCM. Genotyping has also been streamlined to ensure sufficient DNA for the proposed studies and for future PCPT biology studies. Our intent is to provide the highest quality samples and pathological services to meet the needs of the research teams in the Program Project. It is our underlying hypothesis that the quality, reliability and applicability of translational research in PCa can only be guaranteed through the use of high-quality biological specimens that are handled, processed and interpreted in a uniform manner and that can be linked to clinical information and outcome.
描述(由申请人提供):西南肿瘤小组领导的前列腺癌

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

SCOTT M LIPPMAN其他文献

SCOTT M LIPPMAN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('SCOTT M LIPPMAN', 18)}}的其他基金

CA: Administrative Core
CA:行政核心
  • 批准号:
    7510676
  • 财政年份:
    2008
  • 资助金额:
    $ 42.26万
  • 项目类别:
Biology of the Prostate Cancer Prevention Trial (PCPT)
前列腺癌预防试验 (PCPT) 的生物学
  • 批准号:
    6907173
  • 财政年份:
    2005
  • 资助金额:
    $ 42.26万
  • 项目类别:
CORE A "Administration Core"
CORE “管理核心”
  • 批准号:
    7102933
  • 财政年份:
    2005
  • 资助金额:
    $ 42.26万
  • 项目类别:
Biology of the Prostate Cancer Prevention Trial (PCPT)
前列腺癌预防试验 (PCPT) 的生物学
  • 批准号:
    7418582
  • 财政年份:
    2005
  • 资助金额:
    $ 42.26万
  • 项目类别:
Diet and Diet-Related Factors in the PCPT
PCPT 中的饮食和饮食相关因素
  • 批准号:
    7102927
  • 财政年份:
    2005
  • 资助金额:
    $ 42.26万
  • 项目类别:
IGF-1Axis and Insulin Resistance in PCPT
PCPT 中的 IGF-1 轴和胰岛素抵抗
  • 批准号:
    7102930
  • 财政年份:
    2005
  • 资助金额:
    $ 42.26万
  • 项目类别:
Core--Biostatistics/Data Managemente
核心--生物统计/数据管理e
  • 批准号:
    7102936
  • 财政年份:
    2005
  • 资助金额:
    $ 42.26万
  • 项目类别:
Genotypic and Phenotypic Studies of Inflammation in PCPT
PCPT 炎症的基因型和表型研究
  • 批准号:
    7102931
  • 财政年份:
    2005
  • 资助金额:
    $ 42.26万
  • 项目类别:
Biology of the Prostate Cancer Prevention Trial (PCPT)
前列腺癌预防试验 (PCPT) 的生物学
  • 批准号:
    7059466
  • 财政年份:
    2005
  • 资助金额:
    $ 42.26万
  • 项目类别:
Androgen Metabolism in the PCPT
PCPT 中的雄激素代谢
  • 批准号:
    7102925
  • 财政年份:
    2005
  • 资助金额:
    $ 42.26万
  • 项目类别:

相似海外基金

Development of microfluidic enabled CRISPR-Cas9 functional genetic screening technologies for target discovery in cancer immunotherapy
开发微流控 CRISPR-Cas9 功能基因筛选技术,用于癌症免疫治疗中靶点发现
  • 批准号:
    10549221
  • 财政年份:
    2022
  • 资助金额:
    $ 42.26万
  • 项目类别:
Development of microfluidic enabled CRISPR-Cas9 functional genetic screening technologies for target discovery in cancer immunotherapy
开发微流控 CRISPR-Cas9 功能基因筛选技术,用于癌症免疫治疗中靶点发现
  • 批准号:
    10673007
  • 财政年份:
    2022
  • 资助金额:
    $ 42.26万
  • 项目类别:
Development of microfluidic enabled CRISPR-Cas9 functional genetic screening technologies for target discovery in cancer immunotherapy
开发微流控 CRISPR-Cas9 功能基因筛选技术,用于癌症免疫治疗中靶点发现
  • 批准号:
    10188940
  • 财政年份:
    2021
  • 资助金额:
    $ 42.26万
  • 项目类别:
Genetic screening and therapies for nemaline myopathies
线状肌病的基因筛查和治疗
  • 批准号:
    9093821
  • 财政年份:
    2014
  • 资助金额:
    $ 42.26万
  • 项目类别:
Genetic screening and therapies for nemaline myopathies
线状肌病的基因筛查和治疗
  • 批准号:
    8631162
  • 财政年份:
    2014
  • 资助金额:
    $ 42.26万
  • 项目类别:
IGF::OT::IGF: SMOKESCREEN: GENETIC SCREENING TOOL FOR TOBACCO DEPENDENCE & TREAT
IGF::OT::IGF:SmokeScreen:烟草依赖性基因筛查工具
  • 批准号:
    8704651
  • 财政年份:
    2013
  • 资助金额:
    $ 42.26万
  • 项目类别:
IGF::OT::IGF: SMOKESCREEN: GENETIC SCREENING TOOL FOR TOBACCO DEPENDENCE & TREAT
IGF::OT::IGF:SmokeScreen:烟草依赖性基因筛查工具
  • 批准号:
    9061481
  • 财政年份:
    2013
  • 资助金额:
    $ 42.26万
  • 项目类别:
OTHER FUNCTIONS: SMOKESCREEN: GENETIC SCREENING TOOL FOR TOBACCO DEPENDENCE AND
其他功能:SmokeScreen:烟草依赖的基因筛查工具
  • 批准号:
    8507957
  • 财政年份:
    2012
  • 资助金额:
    $ 42.26万
  • 项目类别:
The Ethics of Fragile X Genetic Screening and Testing Across the Lifespan
整个生命周期中脆性 X 基因筛查和测试的伦理
  • 批准号:
    8235080
  • 财政年份:
    2008
  • 资助金额:
    $ 42.26万
  • 项目类别:
The Ethics of Fragile X Genetic Screening and Testing Across the Lifespan
整个生命周期中脆性 X 基因筛查和测试的伦理
  • 批准号:
    7628999
  • 财政年份:
    2008
  • 资助金额:
    $ 42.26万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了